Q9R1N3
PR
Gene name |
Slc4a7 (Nbc, Nbc2, Nbc3, Nbcn1) |
Protein name |
Sodium bicarbonate cotransporter 3 |
Names |
Electroneutral sodium bicarbonate cotransporter 1, NBC-like protein, Solute carrier family 4 member 7 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:117955 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R1N3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R1N3-F1 | Predicted | AlphaFoldDB |
No variants for Q9R1N3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9R1N3 | |||||
No associated diseases with Q9R1N3
18 regional properties for Q9R1N3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 289 - 321 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 323 - 355 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 384 - 416 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 417 - 446 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 447 - 476 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 554 - 586 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 588 - 620 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 622 - 654 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 656 - 687 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 689 - 721 | IPR003107-10 |
| repeat | HAT (Half-A-TPR) repeat | 723 - 755 | IPR003107-11 |
| repeat | HAT (Half-A-TPR) repeat | 757 - 789 | IPR003107-12 |
| repeat | HAT (Half-A-TPR) repeat | 791 - 823 | IPR003107-13 |
| domain | PRP1 splicing factor, N-terminal | 13 - 169 | IPR010491 |
| repeat | Tetratricopeptide repeat | 675 - 708 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 709 - 742 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 743 - 776 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 841 - 874 | IPR019734-4 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| stereocilium | An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| sodium:bicarbonate symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| auditory receptor cell development | The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. |
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| camera-type eye photoreceptor cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. |
| cochlear nucleus development | The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| retina vasculature morphogenesis in camera-type eye | The process in which the vasculature of the retina is generated and organized. |
| retinal cell programmed cell death | Programmed cell death that occurs in the developing retina. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEADGAGEQM | RPLLTRGPDE | EAVVDLGKTS | STVNTKFEKE | ELESHRAVYV | GVHVPFSKES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRRHRHRGHK | HHHRRRKDKD | SDKEDGRESP | SYDTPSQRVQ | FILGTEDDDE | EHIPHDLFTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MDELCYRDGE | EYEWKETARW | LKFEEDVEDG | GDRWSKPYVA | TLSLHSLFEL | RSCILNGTVM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDMRASTLDE | IADMVLDNMI | ASGQLDDSIR | ENVREALLKR | HHHQNEKRFT | SRIPLVRSFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DIGKKHSDPH | LLERNGEGLS | ASRHSLRTGL | SASNLSLRGE | SPLSLLLSHL | LPSSRAGTPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSRCTTPVPT | PQNSPPSSPS | LSRLTSRSSQ | QTQPQAPEVL | VSPDRDDIPR | VVIHPPEEDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EALKGQEQKN | EENTDFTPGI | LASPQSAPGN | LDSSKSGEVK | GNGSGGSREN | STVDFSKVDM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NFMRKIPTGA | EASNVLVGEV | DFLERPIIAF | VRLAPAVLLS | GLTEVPVPTR | FLFLLLGPAG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KAPQYHEIGR | SIATLMTDEI | FHDVAYKAKD | RNDLLSGIDE | FLDQVTVLPP | GEWDPSIRIE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PPKSVPSQEK | RKIPAFPNGS | APVSADPPKE | ADHHAGPELQ | RTGRLFGGLI | LDIKRKAPFF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSDFKDALSL | QCLASILFLY | CACMSPVITF | GGLLGEATEG | RISAIESLFG | ASLTGIAYSL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FAGQPLTILG | STGPVLVFEK | ILFKFCRDYH | LSYLSLRTSI | GLWTSFLCIV | LVATDASSLV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CYITRFTEEA | FAALICIIFI | YEALEKLFHL | GEIYAFNMHN | NLDALTSYTC | VCAEPSNPSN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ETVELWERKN | VTAASISWAN | LTVSECKTFH | GMFVGSACGP | HGPYVPDVLF | WCVVLFFTTF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FLSSFLKQFK | TKRYFPTKVR | STISDFAVFL | TIVIMVAIDY | LVGIPSPKLH | VPEKFEPTDP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SRGWIISPLG | DNPWWTLLIA | AVPALLCTIL | IFMDQQITAV | IINRKEHKLK | KGAGYHLDLL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MVAVMLGVCS | IMGLPWFVAA | TVLSISHVNS | LKVESECSAP | GEQPKFLGIR | EQRVTGLMIF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ILMGLSVFMT | SVLKFIPMPV | LYGVFLYMGV | SSLKGIQFFD | RIKLFGMPAK | HQPDLIYLRY |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VPLWKVHVFT | VVQLTCLVLL | WVIKASAAAV | VFPMMVLALV | FVRKLMDLCF | TKRELSWLDD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LMPESKKKKE | DDKKKKEKEE | AERMLQGDGD | TVHLPFERGS | LLQIPVKTLK | YSPEKPVSVT |
| 1210 | |||||
| INFEDEPSKK | YMDAETSL |