Q5DTL9
PR
Gene name |
Slc4a10 |
Protein name |
Sodium-driven chloride bicarbonate exchanger |
Names |
Solute carrier family 4 member 10 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94229 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DTL9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DTL9-F1 | Predicted | AlphaFoldDB |
37 variants for Q5DTL9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs252382366 | 23 | V>I | No | EVA | |
| rs3413058534 | 77 | R>G | No | EVA | |
| rs3391720228 | 97 | Q>A | No | EVA | |
| rs3388555116 | 154 | W>G | No | EVA | |
| rs3388550424 | 161 | T>M | No | EVA | |
| rs3388558395 | 212 | R>W | No | EVA | |
| rs3388551800 | 213 | V>L | No | EVA | |
| rs28002179 | 273 | N>T | No | EVA | |
| rs3391720292 | 457 | N>I | No | EVA | |
| rs3391692250 | 457 | N>Y | No | EVA | |
| rs3391614767 | 484 | G>T | No | EVA | |
| rs3388557564 | 490 | I>T | No | EVA | |
| rs3388558397 | 492 | R>G | No | EVA | |
| rs3388546747 | 510 | L>S | No | EVA | |
| rs3388553604 | 531 | L>M | No | EVA | |
| rs3388554199 | 541 | A>V | No | EVA | |
| rs3388555150 | 612 | D>H | No | EVA | |
| rs3388551778 | 613 | A>T | No | EVA | |
| rs3388553624 | 614 | S>C | No | EVA | |
| rs3388550706 | 614 | S>N | No | EVA | |
| rs3388549113 | 678 | D>H | No | EVA | |
| rs3388554182 | 679 | T>S | No | EVA | |
| rs3388555176 | 718 | G>D | No | EVA | |
| rs3388553635 | 741 | A>T | No | EVA | |
| rs3388549075 | 769 | I>F | No | EVA | |
| rs3388550377 | 769 | I>S | No | EVA | |
| rs3388554058 | 874 | F>Y | No | EVA | |
| rs3388555501 | 877 | A>T | No | EVA | |
| rs3388550674 | 878 | T>P | No | EVA | |
| rs3388550674 | 878 | T>S | No | EVA | |
| rs3391657888 | 899 | E>A | No | EVA | |
| rs3388550684 | 904 | L>F | No | EVA | |
| rs3391684147 | 907 | R>L | No | EVA | |
| rs3388557548 | 944 | Y>* | No | EVA | |
| rs3388546721 | 947 | A>T | No | EVA | |
| rs3388549089 | 971 | D>Y | No | EVA | |
| rs3388546760 | 1067 | V>L | No | EVA |
No associated diseases with Q5DTL9
Functions
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| apical dendrite | A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| basal dendrite | A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| CA3 pyramidal cell dendrite | A dendrite of a hippocampal CA3 pyramidal cell. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| somatodendritic compartment | The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| sodium:bicarbonate symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| brain morphogenesis | The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| locomotory exploration behavior | The specific movement from place to place of an organism in response to a novel environment. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| pyramidal neuron development | The progression of a pyramidal neuron from its initial formation to its mature state. |
| regulation of cellular pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| regulation of short-term neuronal synaptic plasticity | A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. |
| response to light stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIKDQGAQM | EPLLPTRNDE | EAVVDRGGTR | SILKTHFEKE | DLEGHRTLFI | GVHVPLGGRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHRRHRHRGH | KHRKRDRERD | SGLEDGRESP | SFDTPSQRVQ | FILGTEDDDE | EHLPHDLFTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDEICWREGE | DAEWRETARW | LKFEEDVEDG | GERWSKPYVA | TLSLHSLFEL | RSCILNGTVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDMHANTIEE | IADMVLDQQV | SSGQLNEDVR | HRVHEALMKQ | HHHQNQKKLA | NRIPIVRSFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DIGKKQSEPN | SMDKNAGQVV | SPQSAPACAE | NKNDVSRENS | TVDFSKGLGG | QQKGHTSPCG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MKQRLDKGPP | HQQEREVDLH | FMKKIPPGAE | ASNILVGELE | FLDRTVVAFV | RLSPAVLLQG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAEVPIPSRF | LFILLGPLGK | GQQYHEIGRS | IATLMTDEVF | HDVAYKAKDR | NDLVSGIDEF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LDQVTVLPPG | EWDPSIRIEP | PKNVPSQEKR | KIPAVPNGTA | AHGEAEPHGG | HSGPELQRTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RIFGGLILDI | KRKAPFFWSD | FRDAFSLQCL | ASFLFLYCAC | MSPVITFGGL | LGEATEGRIS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AIESLFGASM | TGIAYSLFGG | QPLTILGSTG | PVLVFEKILF | KFCKEYGLSY | LSLRASIGLW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TATLCIILVA | TDASSLVCYI | TRFTEEAFAS | LICIIFIYEA | LEKLFELSET | YPINMHNDLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLTQYSCNCM | EPHSPSNDTL | KEWRESNLSA | SDIIWGNLTV | SECRSLHGEY | VGRACGHGHP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YVPDVLFWSV | ILFFSTVTMS | ATLKQFKTSR | YFPTKVRSIV | SDFAVFLTIL | CMVLIDYAIG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IPSPKLQVPS | VFKPTRDDRG | WFVTPLGPNP | WWTIIAAIIP | ALLCTILIFM | DQQITAVIIN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RKEHKLKKGC | GYHLDLLMVA | VMLGVCSIMG | LPWFVAATVL | SITHVNSLKL | ESECSAPGEQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PKFLGIREQR | VTGLMIFILM | GSSVFMTSIL | KFIPMPVLYG | VFLYMGASSL | KGIQLFDRIK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LFWMPAKHQP | DFIYLRHVPL | RKVHLFTVIQ | MSCLGLLWII | KVSRAAIVFP | MMVLALVFVR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KLMDFLFTKR | ELSWLDDLMP | ESKKKKLEDA | EKEEEQSMLA | MEDEGTVQLP | LEGHYRDDPS |
| 1090 | 1100 | 1110 | |||
| VINISDEMSK | TAMWGNLLVT | ADNSKEKESR | FPSKSSPS |