A2AJN7
PR
Gene name |
Slc4a11 (BTR1) |
Protein name |
Solute carrier family 4 member 11 |
Names |
Sodium borate cotransporter 1, NaBC1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:269356 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2AJN7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AJN7-F1 | Predicted | AlphaFoldDB |
44 variants for A2AJN7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388591708 | 42 | F>S | No | EVA | |
| rs3388591927 | 72 | L>* | No | EVA | |
| rs3388595774 | 90 | K>N | No | EVA | |
| rs3388591692 | 133 | F>C | No | EVA | |
| rs27259865 | 151 | A>T | No | EVA | |
| rs3388593734 | 152 | K>N | No | EVA | |
| rs3392214524 | 162 | E>* | No | EVA | |
| rs3388591656 | 175 | V>A | No | EVA | |
| rs3388587167 | 254 | T>I | No | EVA | |
| rs3388595685 | 333 | G>D | No | EVA | |
| rs3388593710 | 334 | I>N | No | EVA | |
| rs3388587469 | 344 | Y>N | No | EVA | |
| rs3388596835 | 348 | T>S | No | EVA | |
| rs3388591658 | 351 | L>H | No | EVA | |
| rs3388589213 | 366 | N>K | No | EVA | |
| rs3388591654 | 404 | T>N | No | EVA | |
| rs3388591641 | 436 | N>K | No | EVA | |
| rs3388591660 | 471 | F>L | No | EVA | |
| rs3388592018 | 491 | H>R | No | EVA | |
| rs3388580114 | 494 | T>I | No | EVA | |
| rs3388580114 | 494 | T>K | No | EVA | |
| rs238765895 | 506 | I>T | No | EVA | |
| rs3391938712 | 514 | L>V | No | EVA | |
| rs3392214461 | 515 | H>D | No | EVA | |
| rs3392080423 | 515 | H>Q | No | EVA | |
| rs3392191050 | 533 | S>I | No | EVA | |
| rs256783460 | 536 | G>S | No | EVA | |
| rs3388596818 | 584 | L>M | No | EVA | |
| rs3388591642 | 609 | Y>F | No | EVA | |
| rs3388580164 | 610 | N>K | No | EVA | |
| rs3388589278 | 620 | Q>H | No | EVA | |
| rs3388589221 | 674 | L>H | No | EVA | |
| rs3388585385 | 687 | P>S | No | EVA | |
| rs3388585385 | 687 | P>T | No | EVA | |
| rs3388593737 | 710 | V>E | No | EVA | |
| rs3388587104 | 764 | L>V | No | EVA | |
| rs3388591697 | 772 | L>P | No | EVA | |
| rs3388588386 | 798 | R>K | No | EVA | |
| rs3388591667 | 808 | I>F | No | EVA | |
| rs3388591680 | 836 | M>L | No | EVA | |
| rs3388595011 | 839 | I>T | No | EVA | |
| rs3388593658 | 845 | P>L | No | EVA | |
| rs252721148 | 850 | A>S | No | EVA | |
| rs3388596801 | 858 | A>V | No | EVA |
No associated diseases with A2AJN7
6 regional properties for A2AJN7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 333 - 416 | IPR001680-1 |
| repeat | WD40 repeat | 450 - 491 | IPR001680-2 |
| repeat | WD40 repeat | 494 - 532 | IPR001680-3 |
| repeat | WD40 repeat | 578 - 617 | IPR001680-4 |
| repeat | WD40 repeat | 629 - 673 | IPR001680-5 |
| domain | BOP1, N-terminal domain | 71 - 333 | IPR012953 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vesicle membrane | The lipid bilayer surrounding any membrane-bounded vesicle in the cell. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| active borate transmembrane transporter activity | Enables the transport of borate across a membrane against the concentration gradient. |
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| proton channel activity | Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| proton transmembrane transporter activity | Enables the transfer of a proton from one side of a membrane to the other. |
| sodium channel activity | Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| water transmembrane transporter activity | Enables the transfer of water (H2O) from one side of a membrane to the other. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| borate transport | The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. |
| cellular cation homeostasis | Any process involved in the maintenance of an internal steady state of cations at the level of a cell. |
| cellular hypotonic response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| cellular response to oxidative stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| fluid transport | The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of mesenchymal stem cell differentiation | Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation. |
| regulation of mitochondrial membrane potential | Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQNEHCQDS | GEYFSAGTQG | YFKNNMEDNL | EVREDSLGDE | VFDTVNSSIV | SGESIRFFVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNLEVQPSKS | DLEAATGGCV | LLHTSRKYLK | LKNFEEEVRA | HRDLDGFLAQ | ASIILNETAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLDDVLRTML | NRFALDPNHA | EPDCDLDLLM | AKLFTDAGAP | MESKVHLLSD | TIQGVTATVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVQYEQSWLC | IICTMKTLQK | RHVCISRLVR | PQNWGENSCE | VRFVILVLAP | PKMKSTKTAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVARTFATMF | SDITFRQKLL | KTRTEEEFKE | ALVHQRQLLT | MMMPRAAGHS | MSSLHTHRHP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPPKCKDFFP | FGKGIWMDIM | RRFPVYPMDF | TDGIIGKSKS | VGKYVTTTLF | LYFACLLPTI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFGSLNDENT | NGAIDVQKTI | AGQSIGGLLY | ALFSGQPLVI | LLTTAPLAIY | TQVIRVICDD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YNLDFNAFYA | WTGLWNSFFL | ALYAFLNLSL | LMNLFKRSTE | EIIALFISIT | FVLDAVKGMV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KIFGKYYYGH | HYHTKRTSSL | VSLLGIGRSP | NSSLHTALNA | SLLASPVEMA | TTSSPGSTHS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GQATAVLSLL | IMLGTLWLGY | TLYQFKKSPY | LHPCVRETLS | DCALPIAVLS | FSLIGSYGFQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EIEMSKFRYN | PSESLFEVAQ | IHSLSFKAIG | SAMGLGFLLS | LLFFIEQNLV | AALVNAPENR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVKGTAYHWD | LLLLAIINTG | LSLFGLPWIH | AAYPHSPLHV | RALALVEERV | ENGHIYETIV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DVKETRLTAL | GASVLVGLSL | LLLPFPLQWI | PKPVLYGLFL | YIALTSLDGN | QLFSRVALLL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KEQTSYPPTH | YIRRVPQRKI | HYFTGLQILQ | LLLLCAFGMS | SLPYMKMVFP | LIMIAMIPIR |
| 850 | 860 | ||||
| YNLLPRIIEA | KYLDVMDAEH | RP |