P04919
PR
Gene name |
Slc4a1 (Ae1) |
Protein name |
Band 3 anion transport protein |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20533 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P04919
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P04919-F1 | Predicted | AlphaFoldDB |
47 variants for P04919
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389206518 | 21 | E>* | No | EVA | |
| rs236389570 | 46 | A>V | No | EVA | |
| rs3389206445 | 60 | S>N | No | EVA | |
| rs3389208056 | 64 | P>S | No | EVA | |
| rs3389167770 | 99 | E>* | No | EVA | |
| rs3389208063 | 121 | L>H | No | EVA | |
| rs3402833206 | 179 | E>V | No | EVA | |
| rs8265674 | 198 | A>T | No | EVA | |
| rs8265675 | 204 | P>S | No | EVA | |
| rs3389199985 | 239 | T>N | No | EVA | |
| rs8265682 | 254 | V>I | No | EVA | |
| rs3389194570 | 282 | L>Q | No | EVA | |
| rs3389167829 | 364 | P>H | No | EVA | |
| rs3389180904 | 382 | G>R | No | EVA | |
| rs3389199918 | 427 | A>V | No | EVA | |
| rs3389202308 | 431 | I>F | No | EVA | |
| rs3389216963 | 474 | G>R | No | EVA | |
| rs3389199936 | 507 | V>SDG* | No | EVA | |
| rs3389199914 | 510 | A>G | No | EVA | |
| rs3389207579 | 511 | W>* | No | EVA | |
| rs3389216977 | 512 | I>M | No | EVA | |
| rs3389209424 | 524 | V>A | No | EVA | |
| rs3389206254 | 535 | I>L | No | EVA | |
| rs3402600253 | 537 | R>L | No | EVA | |
| rs3389202370 | 541 | E>V | No | EVA | |
| rs3389176785 | 577 | M>L | No | EVA | |
| rs3389219721 | 595 | L>I | No | EVA | |
| rs3389206298 | 654 | D>V | No | EVA | |
| rs3389204634 | 672 | G>R | No | EVA | |
| rs247092451 | 676 | L>H | No | EVA | |
| rs3389214134 | 690 | L>M | No | EVA | |
| rs3412603589 | 744 | A>D | No | EVA | |
| rs3389207575 | 766 | G>R | No | EVA | |
| rs3389208015 | 790 | L>P | No | EVA | |
| rs3389194555 | 817 | S>F | No | EVA | |
| rs3389199925 | 827 | I>T | No | EVA | |
| rs3389216922 | 831 | F>L | No | EVA | |
| rs3389180948 | 840 | V>M | No | EVA | |
| rs3389167796 | 850 | R>L | No | EVA | |
| rs3389202355 | 858 | Q>* | No | EVA | |
| rs3389180987 | 888 | R>S | No | EVA | |
| rs217913767 | 911 | V>M | No | EVA | |
| rs3389206290 | 915 | E>* | No | EVA | |
| rs3389214136 | 915 | E>D | No | EVA | |
| rs3402046558 | 927 | M>L | No | EVA | |
| rs3402318264 | 929 | V>G | No | EVA | |
| rs3389176769 | 929 | V>M | No | EVA |
No associated diseases with P04919
4 regional properties for P04919
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Bicarbonate transporter-like, transmembrane domain | 680 - 1168 | IPR011531 |
| domain | Band 3 cytoplasmic domain | 352 - 619 | IPR013769 |
| conserved_site | Anion exchange, conserved site | 682 - 693 | IPR018241-1 |
| conserved_site | Anion exchange, conserved site | 829 - 843 | IPR018241-2 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
| cytoplasmic side of plasma membrane | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| ankyrin binding | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| hemoglobin binding | Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| anion transport | The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| blood coagulation | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| erythrocyte development | The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| negative regulation of glycolytic process through fructose-6-phosphate | Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate. |
| negative regulation of oxidoreductase activity | Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. |
| negative regulation of urine volume | Any process that decreases the amount of urine excreted from the body over a unit of time. |
| pH elevation | Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. |
| plasma membrane phospholipid scrambling | The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). |
| positive regulation of T cell proliferation | Any process that activates or increases the rate or extent of T cell proliferation. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| response to activity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. |
| response to arsenic-containing substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. |
| response to carbon dioxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDMRDHEEV | LEIPDRDSEE | ELENIIGQIA | YRDLTIPVTE | MQDPEALPTE | QTATDYVPSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSTPHPSSGQ | VYVELQELMM | DQRNQELQWV | EAAHWIGLEE | NLREDGVWGR | PHLSYLTFWS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLELQKVFSK | GTFLLGLAET | SLAGVANHLL | DCFIYEDQIR | PQDREELLRA | LLLKRSHAED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGNLEGVKPA | VLTRSGGASE | PLLPHQPSLE | TQLYCGQAEG | GSEGPSTSGT | LKIPPDSETT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVLVGRANFL | EKPVLGFVRL | KEAVPLEDLV | LPEPVGFLLV | LLGPEAPHVD | YTQLGRAAAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LMTERVFRIT | ASMAHNREEL | LRSLESFLDC | SLVLPPTDAP | SEKALLNLVP | VQKELLRRRY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPSPAKPDPN | LYNTLDLNGG | KGGPGDEDDP | LRRTGRIFGG | LIRDIRRRYP | YYLSDITDAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPQVLAAVIF | IYFAALSPAV | TFGGLLGEKT | RNLMGVSELL | ISTAVQGILF | ALLGAQPLLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGFSGPLLVF | EEAFFSFCES | NNLEYIVGRA | WIGFWLILLV | MLVVAFEGSF | LVQYISRYTQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EIFSFLISLI | FIYETFSKLI | KIFQDYPLQQ | TYAPVVMKPK | PQGPVPNTAL | FSLVLMAGTF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LLAMTLRKFK | NSTYFPGKLR | RVIGDFGVPI | SILIMVLVDS | FIKGTYTQKL | SVPDGLKVSN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSARGWVIHP | LGLYRLFPTW | MMFASVLPAL | LVFILIFLES | QITTLIVSKP | ERKMIKGSGF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HLDLLLVVGM | GGVAALFGMP | WLSATTVRSV | THANALTVMG | KASGPGAAAQ | IQEVKEQRIS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GLLVSVLVGL | SILMEPILSR | IPLAVLFGIF | LYMGVTSLSG | IQLFDRILLL | FKPPKYHPDV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PFVKRVKTWR | MHLFTGIQII | CLAVLWVVKS | TPASLALPFV | LILTVPLRRL | ILPLIFRELE |
| 910 | 920 | ||||
| LQCLDGDDAK | VTFDEENGLD | EYDEVPMPV |