P13808
PR
Gene name |
Slc4a2 (Ae2) |
Protein name |
Anion exchange protein 2 |
Names |
AE 2, Anion exchanger 2, Band 3-related protein, B3RP, Non-erythroid band 3-like protein, Solute carrier family 4 member 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20535 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P13808
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P13808-F1 | Predicted | AlphaFoldDB |
No variants for P13808
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P13808 | |||||
No associated diseases with P13808
4 regional properties for P13808
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Bicarbonate transporter-like, transmembrane domain | 676 - 1164 | IPR011531 |
| domain | Band 3 cytoplasmic domain | 348 - 615 | IPR013769 |
| conserved_site | Anion exchange, conserved site | 678 - 689 | IPR018241-1 |
| conserved_site | Anion exchange, conserved site | 825 - 839 | IPR018241-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| amelogenesis | The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. |
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| positive regulation of enamel mineralization | Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSAPRRPAS | GADSLHTPEP | ESLSPGTPGF | PEQEEDELRT | LGVERFEEIL | QEAGSRGGEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGRSYGEEDF | EYHRQSSHHI | HHPLSTHLPP | DARRRKTPQG | PGRKPRRRPG | ASPTGETPTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEGEEDEEEA | SEAEGFRAPP | QQPSPATTPS | AVQFFLQEDE | GAERKPERTS | PSPPTQTPHQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAAPRASKGA | QTGTLVEEMV | AVASATAGGD | DGGAAGRPLT | KAQPGHRSYN | LQERRRIGSM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGVEQALLPR | VPTDESEAQT | LATADLDLMK | SHRFEDVPGV | RRHLVRKNAK | GSTQAAREGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPGPTPRARP | RAPHKPHEVF | VELNELLLDK | NQEPQWRETA | RWIKFEEDVE | EETERWGKPH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VASLSFRSLL | ELRRTLAHGA | VLLDLDQQTL | PGVAHQVVEQ | MVISDQIKAE | DRANVLRALL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKHSHPSDEK | EFSFPRNISA | GSLGSLLGHH | HAQGTESDPH | VTEPLIGGVP | ETRLEVDRER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELPPPAPPAG | ITRSKSKHEL | KLLEKIPENA | EATVVLVGCV | EFLSRPTMAF | VRLREAVELD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVLEVPVPVR | FLFLLLGPSS | ANMDYHEIGR | SISTLMSDKQ | FHEAAYLADE | RDDLLTAINA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FLDCSVVLPP | SEVQGEELLR | SVAHFQRQML | KKREEQGRLL | PPGAGLEPKS | AQDKALLQMV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EVAGAAEDDP | LRRTGRPFGG | LIRDVRRRYP | HYLSDFRDAL | DPQCLAAVIF | IYFAALSPAI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TFGGLLGEKT | KDLIGVSELI | MSTALQGVVF | CLLGAQPLLV | IGFSGPLLVF | EEAFFSFCSS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NELEYLVGRV | WIGFWLVFLA | LLMVALEGSF | LVRFVSRFTQ | EIFAFLISLI | FIYETFYKLI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KIFQEHPLHG | CSGSNDSEAG | SSSSSNMTWA | TTILVPDNSS | ASGQSGQEKP | RGQPNTALLS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVLMAGTFFI | AFFLRKFKNS | RFFPGRIRRV | IGDFGVPIAI | LIMVLVDYSI | EDTYTQKLSV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PSGFSVTAPD | KRGWVINPLG | EKTPFPVWMM | VASLLPAVLV | FILIFMETQI | TTLIISKKER |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| MLQKGSGFHL | DLLLIVAMGG | ICALFGLPWL | AAATVRSVTH | ANALTVMSKA | VAPGDKPKIQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EVKEQRVTGL | LVALLVGLSM | VIGDLLRQIP | LAVLFGIFLY | MGVTSLNGIQ | FYERLHLLLM |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PPKHHPDVTY | VKKVRTMRMH | LFTALQLLCL | ALLWAVMSTA | ASLAFPFILI | LTVPLRMVVL |
| 1210 | 1220 | 1230 | |||
| TRIFTEREMK | CLDANEAEPV | FDECEGVDEY | NEMPMPV |