Q4U116
PR
Gene name |
SLC4A4 (NBC1, NBCE1) |
Protein name |
Electrogenic sodium bicarbonate cotransporter 1 |
Names |
Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:503546 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4U116
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4U116-F1 | Predicted | AlphaFoldDB |
No variants for Q4U116
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4U116 | |||||
No associated diseases with Q4U116
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| sodium:bicarbonate symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDEAALDRG | ASFLKHVCDE | EEVEGHHTIY | IGVHVPKSYR | RRRRHKRKAG | HREKKEKERV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SENYSDKSDV | ENADESSSSI | LKPLISPAAE | RIRFILGEED | DSPAPPQLFT | ELDELLAVDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEMEWKETAR | WIKFEEKVEQ | GGERWSKPHV | ATLSLHSLFE | LRTCMEKGSI | MLDREAASLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLVEMIVDHQ | IETGLLKPDL | KDKVTYTLLR | KHRHQTKKSN | LRSLADIGKT | VSSASRMFTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PENGSPAMTH | RNLTSSSLND | ISDKPEKDQL | KNKFMKKLPR | DAEASNVLVG | EVDFLDSPFI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFVRLQQAVM | LGALTEVPVP | TRFLFILLGP | KGKAKSYHEI | GRAIATLMSD | EVFHDIAYKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KDRQDLIAGI | DEFLDEVIVL | PPGEWDPAIR | IEPPKSLPSS | DKRKNMYSGG | ENVQMNGDTP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HDGGHGGGGH | ADCEELQRTG | RFCGGLIKDI | KRKAPFFASD | FYDALNIQAL | SAILFIYLAT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VTNAITFGGL | LGDATDNMQG | VLESFLGTAV | SGAVFCLFAG | QPLTILSSTG | PVLVFERLLF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NFSKDHNFDY | LEFRLWIGLW | SAFLCLILVA | TDASFLVQYF | TRFTEEGFSS | LISFIFIYDA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FKKMIKLADY | YPINSNFKVG | YNTQFSCVCV | PPNPVNISVS | NDTTLAPEDL | QTVSSADMYH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NATFDWALLT | KKECLKYEGK | LVGNNCDFVP | DITLMSFILF | LGTYTSSMAL | KKFKTSRYFP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TTARKLISDF | AIILSILIFC | VIDALVGVDT | PKLIVPSEFK | PTSPNRGWFV | PPFGGNPWWV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YLAAAIPALL | VTILIFMDQQ | ITAVIVNRKE | HKLKKGAGYH | LDLFWVAILM | VVCSFMALPW |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YVAATVISIA | HIDSLKMETE | TSAPGEQPKF | LGVREQRVTG | TLVFILTGLS | VFMAPILKFI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PMPVLYGVFL | YMGVASLNGV | QFMDRLKLLL | MPLKHQPDFI | YLRHVPLRRV | HLFTFLQVLC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LALLWILKST | VAAIIFPVMI | LALVAVRKGM | DYLFSQHDLS | FLDDVIPEKD | KKKKEDEKKK |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| KKKKGSLDSD | SDDSDCPYSE | KVPSIKIPMD | IMEQQPFLSD | SKPSDRERSP | TFLERHTSC |