AiPD: Autoinhibited Protein Database

Q6U841

Gene name	SLC4A10
Protein name	Sodium-driven chloride bicarbonate exchanger
Names	Solute carrier family 4 member 10
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57282
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-132 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

30-132 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q6U841

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6U841-F1	Predicted				AlphaFoldDB

655 variants for Q6U841

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1289717040 CA349210694	2	E>K		No	ClinGen gnomAD
TCGA novel	3	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA59593294 rs1051775487	3	I>V		No	ClinGen TOPMed gnomAD
CA1931065 rs370756267	6	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA59593296 rs771437643	9	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1573940971 CA349210755	10	M>R		No	ClinGen Ensembl
rs1230555417 CA349210767	12	P>T		No	ClinGen TOPMed gnomAD
rs1196591132 CA349210794	16	T>M		No	ClinGen Ensembl
TCGA novel	17	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA59694707 rs749652105	18	N>H		No	ClinGen Ensembl
CA349216321 rs1559212321	19	D>Y		No	ClinGen Ensembl
rs1235280305 CA349216387	23	V>A		No	ClinGen TOPMed
rs756214742 CA1931097	26	R>I		No	ClinGen ExAC gnomAD
rs1196223525 CA349216443	27	G>D		No	ClinGen gnomAD
rs1574880678 CA349216470	29	T>N		No	ClinGen Ensembl
CA349216478 rs1261502891	30	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs764362891 CA1931098	30	R>H		No	ClinGen ExAC TOPMed gnomAD
CA349216497 rs1368523271	32	I>V		No	ClinGen gnomAD
rs914673973 CA59694747	34	K>Q		No	ClinGen TOPMed
CA349216517 rs1161093935	35	T>A		No	ClinGen gnomAD
rs1574880880 CA349216520	35	T>K		No	ClinGen Ensembl
CA349216525 rs1364498206	36	H>R		No	ClinGen gnomAD
rs1400244361 CA349216544	38	E>D		No	ClinGen TOPMed gnomAD
rs760278871 CA349216551	39	K>N		No	ClinGen ExAC TOPMed gnomAD
rs754019335 CA1931099	39	K>R		No	ClinGen ExAC gnomAD
CA1931121 rs758894714	46	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1008275 rs780653423 CA1931122 COSM1590797	46	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA59718234 rs567151480	51	G>A		No	ClinGen Ensembl
rs908530845 CA59718251	55	P>T		No	ClinGen Ensembl
TCGA novel	56	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349216142 rs1424392466	57	G>E		No	ClinGen TOPMed
rs1575047304 CA349216139	57	G>R		No	ClinGen Ensembl
rs1026519712 CA59718261	59	R>G		No	ClinGen TOPMed
CA59718265 rs759673660	59	R>I		No	ClinGen TOPMed
rs770073010 CA349216167	61	S>N		No	ClinGen ExAC TOPMed gnomAD
rs770073010 CA1931127	61	S>T		No	ClinGen ExAC TOPMed gnomAD
rs372550007 CA1931129	63	R>Q		No	ClinGen ESP ExAC gnomAD
CA1931130 rs770723696	64	R>C		No	ClinGen ExAC gnomAD
CA59718301 rs1038439527	64	R>H		No	ClinGen TOPMed gnomAD
rs774276605 CA349216194	65	H>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	65	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	67	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349216210 rs1372967649	68	R>C		No	ClinGen TOPMed gnomAD
COSM1008277 CA1931132 COSM1153502 rs759420527	68	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs544770669 CA1931133	70	H>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	71	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775884037 CA59718319	72	H>R		No	ClinGen Ensembl
rs776546911 CA1931134	73	R>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	73	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	77	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931136 rs762784608	79	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1303812995 CA349216301	79	R>K		No	ClinGen gnomAD
CA349216338 rs1310853653	82	G>R		No	ClinGen gnomAD
CA349216377 rs1259341628	84	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA349216370 rs1227805051	84	E>G		No	ClinGen TOPMed
rs1365933953 CA349216379	85	D>N		No	ClinGen TOPMed
rs766687720 CA349216420	88	E>*		No	ClinGen ExAC gnomAD
rs766687720 CA1931139	88	E>Q		No	ClinGen ExAC gnomAD
rs1480081907 CA349216433	89	S>A		No	ClinGen gnomAD
CA349216431 rs1480081907	89	S>P		No	ClinGen gnomAD
CA349216429 rs1480081907	89	S>T		No	ClinGen gnomAD
rs1479368740 CA349216449	90	P>L		No	ClinGen gnomAD
CA349216444 rs1426977623	90	P>T		No	ClinGen gnomAD
rs752056848 CA1931140	91	S>Y		No	ClinGen ExAC gnomAD
CA349218858 rs753216065	93	D>A		No	ClinGen ExAC TOPMed gnomAD
CA1931162 rs753216065	93	D>G		No	ClinGen ExAC TOPMed gnomAD
CA59738115 rs556172929	94	T>I		No	ClinGen TOPMed gnomAD
CA349218864 rs556172929	94	T>N		No	ClinGen TOPMed gnomAD
rs770849707 CA59738136	96	S>A		No	ClinGen Ensembl
CA59738139 rs1056251804	98	R>K		No	ClinGen Ensembl
CA349218891 rs1489178338	99	V>I		No	ClinGen gnomAD
TCGA novel	103	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs267598940 CA59738160	104	G>E		No	ClinGen Ensembl
TCGA novel	105	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM263726 rs756835311 CA1931166	106	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA349218937 rs756835311	106	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA1931167 rs778663790	107	D>Y		No	ClinGen ExAC gnomAD
rs1183624083 CA349218953	108	D>Y		No	ClinGen gnomAD
rs1559366385 CA349218969	110	E>A		No	ClinGen Ensembl
CA1931169 rs758229636	110	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs780074330 CA1931170	111	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1399384677 CA349218983	112	H>Y		No	ClinGen gnomAD
rs929159822 CA59738224	113	I>F		No	ClinGen TOPMed
RCV000517001 CA349218990 rs929159822	113	I>V		No	ClinGen ClinVar TOPMed dbSNP
rs1192069505 CA349218997	114	P>S		No	ClinGen gnomAD
rs769949115 CA1931172	115	H>R		No	ClinGen ExAC gnomAD
CA1931171 rs746977573	115	H>Y		No	ClinGen ExAC gnomAD
CA59738232 rs368047320	116	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1450848104 CA349219007	116	D>N		No	ClinGen gnomAD
CA1931175 rs771054985	122	D>G		No	ClinGen ExAC gnomAD
CA1931176 rs774693047	123	E>K		No	ClinGen ExAC gnomAD
CA1931177 rs372570626	125	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA349219071 rs372570626	125	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA349219080 rs1203096401	126	W>L		No	ClinGen gnomAD
CA1931178 rs201440727 COSM84639	127	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1931179 rs201440727	127	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs761191332 CA1931180	128	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA59738375 rs372141989	132	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs372141989 CA349219117	132	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs372141989 CA1931183	132	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs926875340 CA59738382	133	E>G		No	ClinGen TOPMed
CA349219138 rs899870875	135	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM3748712 CA349219141 COSM3748711 rs1382333814 COSM385342	135	R>Q	lung stomach [Cosmic]	No	ClinGen cosmic curated gnomAD
rs76923622 CA59748572	141	L>F		No	ClinGen Ensembl
rs200684832 CA59748577	144	E>*		No	ClinGen Ensembl
TCGA novel	151	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931200 rs777176613	152	E>D		No	ClinGen ExAC gnomAD
rs1253123554 CA349219286	154	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs764837556 CA349219337	161	T>I		No	ClinGen ExAC gnomAD
rs764837556 CA1931202	161	T>N		No	ClinGen ExAC gnomAD
CA349219350 rs1197648540	163	S>L		No	ClinGen gnomAD
CA349219443 rs1301577652	176	N>S		No	ClinGen TOPMed
CA1931206 rs751395564	177	G>*		No	ClinGen ExAC gnomAD
rs1190258769 CA349219450	177	G>A		No	ClinGen Ensembl
rs754880370 CA1931207	178	T>S		No	ClinGen ExAC gnomAD
TCGA novel	181	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs954295335 CA59748624	181	L>R		No	ClinGen Ensembl
rs1301022818 CA349219483	183	M>V		No	ClinGen gnomAD
CA349219499 rs1344686373	185	A>T		No	ClinGen gnomAD
COSM1008285 COSM1590794 rs537192317 CA1931209	186	N>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs757242243 CA1931210	187	T>N		No	ClinGen ExAC gnomAD
rs1175522702 CA349219539	190	E>D		No	ClinGen TOPMed
rs1575300576 CA349219532	190	E>K		No	ClinGen Ensembl
CA1931212 rs745983686	192	A>E		No	ClinGen ExAC gnomAD
rs779072501 CA1931211	192	A>T		No	ClinGen ExAC gnomAD
CA349219552 rs1361807499	193	D>Y		No	ClinGen gnomAD
TCGA novel	194	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	195	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931226 rs547965934	199	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	201	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752528225 CA1931227	202	S>L		No	ClinGen ExAC gnomAD
rs1445996896 CA349219709	203	G>D		No	ClinGen gnomAD
CA349219703 rs1243199230	203	G>S		No	ClinGen gnomAD
CA349219737 rs1457584367	206	N>S		No	ClinGen TOPMed
COSM1528611 CA1931228 COSM1528612 rs756056078	210	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA59753082 rs754718619	210	R>H		No	ClinGen TOPMed gnomAD
rs763974777 CA1931229	211	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA349219806 rs1160967516	212	R>T		No	ClinGen gnomAD
rs758528961 CA1931231	214	H>Q		No	ClinGen ExAC gnomAD
rs750507463 CA1931230	214	H>R		No	ClinGen ExAC gnomAD
rs1158699240 CA349219823	214	H>Y		No	ClinGen gnomAD
CA1931232 rs780189691	215	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	215	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931233 rs747266395	216	A>T		No	ClinGen ExAC TOPMed gnomAD
CA59753117 CA349219851 rs868716862	218	M>I		No	ClinGen Ensembl
rs755289229 CA1931234	218	M>K		No	ClinGen ExAC gnomAD
CA1931235 rs781602212	220	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs925077721 CA59753120	220	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA349219898 rs1265693143	222	H>Q		No	ClinGen TOPMed
rs1223068536 CA349219902	223	H>N		No	ClinGen TOPMed
CA1931237 rs770330131	225	N>S		No	ClinGen ExAC gnomAD
CA349219949 rs1305273398	226	Q>H		No	ClinGen gnomAD
CA1931238 rs373648693	227	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs377627238 CA1931239	228	K>N		No	ClinGen ESP ExAC gnomAD
CA1931240 rs770571506	229	L>F		No	ClinGen ExAC gnomAD
TCGA novel	229	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	232	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349220024 rs1460376560	234	P>A		No	ClinGen gnomAD
rs1575340706 CA349220030	234	P>R		No	ClinGen Ensembl
CA349220022 rs1460376560	234	P>T		No	ClinGen gnomAD
CA349220033 rs1575340733	235	I>L		No	ClinGen Ensembl
CA349220045 rs1201172230	236	V>F		No	ClinGen gnomAD
CA349220060 rs1219783826	237	R>H		No	ClinGen TOPMed
rs1219783826 CA349220063	237	R>L		No	ClinGen TOPMed
TCGA novel	240	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349220098 rs1342999545	241	D>Y		No	ClinGen TOPMed
rs1299615928 CA349220116	242	I>N		No	ClinGen TOPMed
CA59753173 rs867008585	243	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA349220198 rs759282717	249	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759282717 CA1931242	249	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA349220569 rs1178622733	250	N>H		No	ClinGen gnomAD
CA349220586 rs1248129326	252	M>V		No	ClinGen TOPMed gnomAD
CA349220593 rs1399636004	253	D>N		No	ClinGen TOPMed
CA349220601 rs1559411656	254	K>Q		No	ClinGen Ensembl
TCGA novel	255	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349220615 rs1414105895	255	N>K		No	ClinGen gnomAD
rs1480113881 CA348976883	258	Q>H		No	ClinGen gnomAD
CA1931259 rs773976374	260	V>A		No	ClinGen ExAC TOPMed gnomAD
rs550963888 CA1931258	260	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA1931261 rs745409738	261	S>F		No	ClinGen ExAC gnomAD
rs745409738 CA1931260	261	S>Y		No	ClinGen ExAC gnomAD
CA1931262 rs775059170	262	P>S		No	ClinGen ExAC gnomAD
TCGA novel	265	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931263 rs535560207	266	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1411794285 CA348976932	267	A>G		No	ClinGen gnomAD
TCGA novel	267	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931264 rs763798251	268	C>R		No	ClinGen ExAC gnomAD
rs1425561778 CA348976975	273	N>S		No	ClinGen gnomAD
CA1931266 rs761718725	274	D>E		No	ClinGen ExAC TOPMed gnomAD
rs776505084 CA1931265	274	D>G		No	ClinGen ExAC gnomAD
rs1305300252 CA348976979	274	D>N		No	ClinGen gnomAD
rs1305300252 CA348976981	274	D>Y		No	ClinGen gnomAD
rs765203158 CA1931267	279	N>H		No	ClinGen ExAC gnomAD
rs1166704487 CA348977017	279	N>S		No	ClinGen TOPMed
rs1239250106 CA348977022	280	S>C		No	ClinGen gnomAD
CA348977024 rs1215755332	280	S>N		No	ClinGen gnomAD
rs1215755332 CA348977025	280	S>T		No	ClinGen gnomAD
rs1270301042 CA348977031	281	T>A		No	ClinGen gnomAD
CA1931269 rs759670652	283	D>E		No	ClinGen ExAC TOPMed gnomAD
rs751637683 CA59583757	283	D>G		No	ClinGen ExAC gnomAD
rs751637683 CA1931268	283	D>V		No	ClinGen ExAC gnomAD
CA1931270 rs767720568	285	S>G		No	ClinGen ExAC gnomAD
CA348977057 rs1221650821	285	S>N		No	ClinGen gnomAD
rs759594062 CA1931287	287	G>A		No	ClinGen ExAC gnomAD
rs759594062 CA348977083	287	G>V		No	ClinGen ExAC gnomAD
CA1931288 rs371563853	288	L>P		No	ClinGen ESP ExAC gnomAD
CA348977087 rs371563853	288	L>Q		No	ClinGen ESP ExAC gnomAD
CA1931290 rs760783234	290	G>D		No	ClinGen ExAC TOPMed gnomAD
rs181577709 CA1931292	292	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348977111 rs181577709	292	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348977120 rs1279892391	293	K>N		No	ClinGen gnomAD
rs1352642908 CA348977125	294	G>E		No	ClinGen gnomAD
CA348977131 rs1283386085	295	H>P		No	ClinGen gnomAD
CA1931293 rs754250799	296	T>I		No	ClinGen ExAC TOPMed gnomAD
CA348977139 rs754250799	296	T>N		No	ClinGen ExAC TOPMed gnomAD
CA348977140 rs754250799	296	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1205587768 CA348977141	297	S>G		No	ClinGen gnomAD
CA1931294 rs757750211	297	S>N		No	ClinGen ExAC gnomAD
rs979881588 CA59584865	299	C>R		No	ClinGen TOPMed gnomAD
rs1234950167 CA348977160	299	C>W		No	ClinGen gnomAD
rs1332160021 CA348977194	304	R>K		No	ClinGen gnomAD
CA348977209 rs1315350331	306	E>A		No	ClinGen TOPMed
rs867899383 CA59584878	306	E>K		No	ClinGen Ensembl
rs145064806 CA1931296	308	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348977232 rs1352439192	309	P>L		No	ClinGen TOPMed
CA1931297 rs757883905	310	P>T		No	ClinGen ExAC gnomAD
CA1931298 rs779412073	311	H>Y		No	ClinGen ExAC gnomAD
CA1931299 rs746573378	312	Q>L		No	ClinGen ExAC gnomAD
CA348977260 rs1412871926	314	E>K		No	ClinGen TOPMed
rs768193405 CA1931300	316	E>G		No	ClinGen ExAC TOPMed gnomAD
CA348977298 rs1268725961	317	V>A		No	ClinGen TOPMed gnomAD
CA348977299 rs1268725961	317	V>G		No	ClinGen TOPMed gnomAD
TCGA novel	317	V>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348977355 rs1359446726	325	I>V		No	ClinGen TOPMed
rs1575417532 RCV000997247 CA348977370	327	P>L		No	ClinGen ClinVar Ensembl dbSNP
rs536638756 CA1931323	330	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs749146051 CA1931324	331	A>S		No	ClinGen ExAC gnomAD
CA1931326 rs774405059	332	S>T		No	ClinGen ExAC gnomAD
rs768858140 CA1931328	334	I>V		No	ClinGen ExAC gnomAD
TCGA novel	335	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348977435 rs1363162131	338	E>K		No	ClinGen TOPMed
CA348977444 rs776950452	339	L>V		No	ClinGen ExAC gnomAD
rs762145468 CA1931330	340	E>G		No	ClinGen ExAC gnomAD
rs552228145 CA1931331	341	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA348977465 rs1162187328	342	L>S		No	ClinGen TOPMed
CA1931334 rs763437005	344	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1400422 CA1931333 COSM1400423 rs763437005	344	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201945239 CA1931336	348	A>E		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA1931335 rs201945239 COSM3961358 COSM3961357 COSM3961356	348	A>G	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC gnomAD
CA348977501 rs201945239 COSM1226419 COSM1226418	348	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC gnomAD
CA348977538 rs1265256059	354	P>S		No	ClinGen gnomAD
CA59588233 rs887353064	355	A>G		No	ClinGen TOPMed
COSM1148339 COSM717255 rs534723058 COSM1647036 CA1931338	356	V>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA348977557 rs755730225 CA1931340 COSM370027	357	L>F	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1575417972 CA348977571	359	Q>H		No	ClinGen Ensembl
TCGA novel	360	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1553605433 CA348977597 RCV000518674	364	V>I		No	ClinGen ClinVar Ensembl dbSNP
rs369816610 CA1931342	366	I>V		No	ClinGen ESP ExAC gnomAD
CA59588262 rs1039822470	368	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	368	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1170572814 CA348977648	370	F>V		No	ClinGen TOPMed
rs778788467 CA1931362	371	L>F		No	ClinGen ExAC gnomAD
TCGA novel	371	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348977663 rs1431509828	372	F>Y		No	ClinGen TOPMed
rs1374330321 CA348977672	373	I>T		No	ClinGen gnomAD
CA59589822 rs867004542	376	G>E		No	ClinGen Ensembl
CA1931364 rs562389348	377	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs748183998 CA1931366	381	G>D		No	ClinGen ExAC gnomAD
TCGA novel	383	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	384	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348977759 rs1325144049	386	E>D		No	ClinGen gnomAD
CA1931368 rs777818237	391	I>T		No	ClinGen ExAC gnomAD
rs770494661 CA1931367	391	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1480765679 CA348977798	393	T>A		No	ClinGen gnomAD
rs996785470 CA59589861	396	T>S		No	ClinGen Ensembl
rs61750845 CA1931381	403	V>I		No	ClinGen ExAC TOPMed gnomAD
CA348977890 rs1320143669	404	A>G		No	ClinGen gnomAD
TCGA novel	404	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758283497 CA1931382	404	A>T		No	ClinGen ExAC gnomAD
TCGA novel	404	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3390067 COSM1157820 CA1931383 rs558073659 COSM268458	410	R>C	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs911712300 CA59595706	410	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA348977938 rs1443852265	411	N>S		No	ClinGen TOPMed
rs61748241 COSM717252 CA1931387 COSM1647033 COSM1148342	413	L>F	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA348977960 rs1467335624	414	V>A		No	ClinGen gnomAD
rs1000114957 CA59595734	417	I>M		No	ClinGen Ensembl
CA1931389 rs779161996	417	I>T		No	ClinGen ExAC TOPMed gnomAD
CA348977999 rs1362110628	420	F>S		No	ClinGen gnomAD
CA1931391 rs370972333	421	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs775931599 CA1931392	423	Q>R		No	ClinGen ExAC gnomAD
CA348978034 rs1450453852	426	V>L		No	ClinGen TOPMed
rs1293712408 CA348978049	428	P>L		No	ClinGen gnomAD
rs769090948 CA1931395	432	W>*		No	ClinGen ExAC gnomAD
rs1242764753 CA348978112	437	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	440	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	442	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776173488 CA1931396	446	S>P		No	ClinGen ExAC gnomAD
CA348978373 rs1430603894	449	K>N		No	ClinGen TOPMed gnomAD
CA348978402 rs1461922305	452	I>F		No	ClinGen gnomAD
rs1276917826 CA348978412	453	P>T		No	ClinGen TOPMed gnomAD
rs1201165419 CA348978427	454	A>S		No	ClinGen TOPMed
rs1201165419 CA348978423	454	A>T		No	ClinGen TOPMed
rs769200448 CA1931418	454	A>V		No	ClinGen ExAC gnomAD
CA1931419 rs777019496	456	P>R		No	ClinGen ExAC gnomAD
rs185463710 CA1931420	458	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs575260520 CA1931421	459	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1156277746 CA348978506	459	T>I		No	ClinGen gnomAD
rs545573563 CA1931422	460	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545573563 CA348978518	460	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545573563 CA348978517	460	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348978530 rs1469984993	461	A>V		No	ClinGen gnomAD
CA59599196 rs868666111	462	H>N		No	ClinGen Ensembl
rs1342960553 CA348978539	462	H>R		No	ClinGen gnomAD
CA59599202 COSM3837164 rs267598941 COSM3837165 COSM3837163	464	E>K	breast Variant assessed as Somatic; 5.479e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA1931423 rs762676328	465	A>V		No	ClinGen ExAC TOPMed gnomAD
rs575906578 CA1931425	468	H>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA348978624 rs759310135	468	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs755119585 CA1931427	469	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA348978662 rs1324443116	470	G>E		No	ClinGen gnomAD
rs1224694586 CA348978704	472	S>R		No	ClinGen TOPMed
rs1205614100 CA348978735	474	P>L		No	ClinGen TOPMed gnomAD
rs757317128 CA1931429	474	P>S		No	ClinGen ExAC gnomAD
TCGA novel	474	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM207519 COSM1590788 rs866130595 CA59599276	478	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA348979186 rs1302663372	483	F>L		No	ClinGen TOPMed
rs1466683340 TCGA novel CA348979194	485	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA348979201 rs1326549571	486	L>V		No	ClinGen gnomAD
rs969330890 CA59601430	487	I>T		No	ClinGen TOPMed
rs751763132 CA1931455	491	K>R		No	ClinGen ExAC gnomAD
TCGA novel	492	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755321628 CA1931456	494	A>S		No	ClinGen ExAC gnomAD
rs755321628 CA348979255	494	A>T		No	ClinGen ExAC gnomAD
COSM717250 COSM1148344 CA1931457 COSM1647031 rs781388732	498	W>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA348979291 rs1439205908	499	S>G		No	ClinGen TOPMed
TCGA novel	500	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1148345 rs1198476375 COSM717249 CA348979340 COSM1647030	502	R>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA348979376 rs1472866885	505	F>L		No	ClinGen gnomAD
rs1361069977 CA348979533	517	Y>C		No	ClinGen TOPMed gnomAD
CA348979551 rs370855511	518	C>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282104575 CA348979555	519	A>T		No	ClinGen TOPMed
CA1931462 rs201661706	519	A>V		No	ClinGen ExAC gnomAD
rs1018694709 CA59601492	521	M>V		No	ClinGen TOPMed
TCGA novel	522	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931466 rs775116534	524	V>I		No	ClinGen ExAC TOPMed gnomAD
rs556027373 CA1931467	525	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA348979659 rs1313617772	526	T>M		No	ClinGen gnomAD
TCGA novel	526	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	529	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1483301442 CA348979713	531	L>Q		No	ClinGen gnomAD
CA1931471 rs766392662	534	A>E		No	ClinGen ExAC gnomAD
rs1207023538 CA348979749	534	A>T		No	ClinGen gnomAD
CA59601581 rs751709773	538	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1931473 rs759649791	538	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1931472 rs751709773	538	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1931484 rs199634510 RCV000713341	546	F>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA1931485 rs768472091	549	S>F		No	ClinGen ExAC gnomAD
rs1475256454 CA348980164	553	I>V		No	ClinGen Ensembl
CA1931488 rs769810857	554	A>T		No	ClinGen ExAC gnomAD
rs1295149066 CA348980182	554	A>V		No	ClinGen gnomAD
rs1002777223 CA59602150	559	G>A		No	ClinGen TOPMed gnomAD
CA348980254 rs1364108320	560	G>R		No	ClinGen gnomAD
rs1559502936 CA348980293	563	L>F		No	ClinGen Ensembl
CA1931489 rs774293851	571	P>Q		No	ClinGen ExAC gnomAD
CA1931490 rs759723964	572	V>I		No	ClinGen ExAC gnomAD
COSM1590786 CA348980463 rs534495211 COSM1008300	577	K>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA gnomAD
TCGA novel	583	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348980661 rs1396843663	587	G>E		No	ClinGen TOPMed
CA1931511 rs775804216	587	G>R		No	ClinGen ExAC gnomAD
rs777130386 CA1931514	597	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	604	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	605	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931518 rs757799595	606	I>V		No	ClinGen ExAC TOPMed gnomAD
CA348980845 rs1346008260	607	I>T		No	ClinGen gnomAD
CA348980880 rs1276956226	613	A>T		No	ClinGen gnomAD
rs1442274736 CA348980898 COSM145945 COSM1317072	615	S>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1382525548 CA348980924	619	Y>C		No	ClinGen gnomAD
CA348980921 rs1254655168	619	Y>H		No	ClinGen gnomAD
CA59602937 rs370148354	622	R>W		No	ClinGen ESP gnomAD
rs572184720 CA1931521	634	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348981176 rs1422612562	640	A>G		No	ClinGen gnomAD
CA1931525 rs777534270	649	E>D		No	ClinGen ExAC gnomAD
CA59603016 rs891892148	650	A>T		No	ClinGen Ensembl
rs749267898 CA1931526	650	A>V		No	ClinGen ExAC gnomAD
rs766098551 CA1931528	653	I>V		No	ClinGen ExAC gnomAD
rs747149436 CA1931530	655	M>L		No	ClinGen ExAC TOPMed gnomAD
CA348981441 rs1277163349	655	M>R		No	ClinGen gnomAD
CA1931529 rs747149436	655	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1340688247 CA348981451	656	H>N		No	ClinGen gnomAD
CA348981463 rs1330413161	656	H>Q		No	ClinGen TOPMed
CA348981458 rs1575573169	656	H>R		No	ClinGen Ensembl
CA1931531 rs777005850	658	D>N		No	ClinGen ExAC gnomAD
TCGA novel	660	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931533 rs61732696	661	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763486116 CA1931535	666	S>L		No	ClinGen ExAC TOPMed gnomAD
rs773500702 CA1931534	666	S>P		No	ClinGen ExAC gnomAD
CA1931556 rs371135427	668	N>D		No	ClinGen ESP ExAC gnomAD
CA348978411 rs1386707191	669	C>Y		No	ClinGen gnomAD
rs374697376 CA1931557	672	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1931559 rs752195039	673	H>R		No	ClinGen ExAC gnomAD
CA1931560 rs199725063	675	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1931561 rs371522013	676	S>N		No	ClinGen ESP ExAC gnomAD
CA348978505 rs1208796708	677	N>I		No	ClinGen gnomAD
rs1484671365 CA348978515	678	G>D		No	ClinGen gnomAD
CA348978531 rs1204367305	679	T>I		No	ClinGen gnomAD
CA1931563 rs757130894	681	K>R		No	ClinGen ExAC TOPMed gnomAD
rs941456216 CA59603907	682	E>A		No	ClinGen TOPMed
CA1931564 rs376393572	682	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs750415816 CA1931565	685	E>A		No	ClinGen ExAC gnomAD
CA1931566 rs755059131	687	N>S		No	ClinGen ExAC gnomAD
CA348978663 rs1303810068	688	I>N		No	ClinGen gnomAD
rs781303491 CA1931567	688	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	692	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931568 rs367992718	693	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs367992718 CA348978741	693	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA59603959 rs900050569	694	I>S		No	ClinGen TOPMed
TCGA novel	695	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	697	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348978852 rs1458349611	698	L>P		No	ClinGen TOPMed
rs1228514450 CA348978879	699	T>I		No	ClinGen gnomAD
rs1435419738 CA348978905	701	S>L		No	ClinGen TOPMed gnomAD
CA1931590 rs369971543	706	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA1931591 rs779213440	708	G>A		No	ClinGen ExAC gnomAD
TCGA novel	708	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931594 rs199675055	709	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1931592 rs555576128	709	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1931595 rs746460208	710	Y>H		No	ClinGen ExAC gnomAD
rs768080951 CA348979443	711	V>F		No	ClinGen ExAC gnomAD
rs768080951 CA1931596	711	V>I		No	ClinGen ExAC gnomAD
CA59606799 rs148092998	713	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148092998 CA1931599	713	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1931598 rs567598753	713	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs762856959 CA1931601	717	H>R		No	ClinGen ExAC gnomAD
rs1452768741 CA348979517	717	H>Y		No	ClinGen gnomAD
rs1432170017 CA348979540	718	D>E		No	ClinGen TOPMed gnomAD
CA1931602 rs766275453	718	D>H		No	ClinGen ExAC gnomAD
rs751485004 CA1931603	719	H>Q		No	ClinGen ExAC gnomAD
rs1169042017 CA348979548	719	H>Y		No	ClinGen gnomAD
COSM1400429 CA348979563 rs1164720538 COSM1400428	720	P>S	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1416549696 CA348979572	721	Y>H		No	ClinGen TOPMed
rs760763613 CA1931604	722	V>I		No	ClinGen ExAC gnomAD
CA59606820 rs1040079256	726	L>Q		No	ClinGen Ensembl
TCGA novel	729	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753956303 CA1931606	731	I>F		No	ClinGen ExAC gnomAD
CA1931607 rs753956303	731	I>V		No	ClinGen ExAC gnomAD
CA1931609 rs779162070	733	F>I		No	ClinGen ExAC gnomAD
CA1931608 rs779162070	733	F>L		No	ClinGen ExAC gnomAD
TCGA novel	737	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1264251736 CA348979773	737	V>I		No	ClinGen TOPMed
rs758693082 CA1931610	738	T>A		No	ClinGen ExAC gnomAD
TCGA novel	740	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348979854 rs1306818511	742	T>S		No	ClinGen gnomAD
COSM2150957 COSM2150956 rs770016661 COSM2150958 CA59606877	746	F>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
rs780100872 CA1931614	748	T>S		No	ClinGen ExAC TOPMed gnomAD
rs545143437 CA1931617	749	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA1931616 rs545143437	749	S>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	750	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348979993 rs1248874380	750	R>T		No	ClinGen gnomAD
rs747597084 CA1931632	756	V>I		No	ClinGen ExAC gnomAD
CA1931633 rs769463278	757	R>Q		No	ClinGen ExAC gnomAD
rs777520871 CA1931634	759	I>T		No	ClinGen ExAC gnomAD
rs1006192017 CA59607740	759	I>V		No	ClinGen gnomAD
rs1416319749 CA348981273	760	V>M		No	ClinGen gnomAD
CA348981395 rs1559606347	766	F>C		No	ClinGen Ensembl
rs1163548812 CA348981416	768	T>A		No	ClinGen TOPMed gnomAD
CA1931635 rs748874179	771	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA348981479 rs1336754143	772	M>I		No	ClinGen TOPMed
CA348981468 rs1238896846	772	M>V		No	ClinGen TOPMed
CA1931637 rs770661028	775	I>L		No	ClinGen ExAC gnomAD
CA1931636 rs770661028	775	I>V		No	ClinGen ExAC gnomAD
rs771937357 CA348981575	779	I>F		No	ClinGen ExAC gnomAD
rs997634997 CA59607791	779	I>M		No	ClinGen Ensembl
rs1559606606 CA348981579	779	I>T		No	ClinGen Ensembl
rs771937357 CA1931639	779	I>V		No	ClinGen ExAC gnomAD
CA1931640 rs775408136	780	G>E		No	ClinGen ExAC
rs267598943 CA59607795	782	P>T		No	ClinGen Ensembl
CA1931643 rs201351567 RCV000516937	790	S>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA59607802 rs967086666	791	V>L		No	ClinGen TOPMed
TCGA novel	792	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348981695 rs1237003487	795	T>P		No	ClinGen gnomAD
rs1278572698 CA348981708	797	D>H		No	ClinGen gnomAD
rs371575939 CA59608687	799	R>H		No	ClinGen ESP gnomAD
CA1931661 rs75945400	802	F>V		No	ClinGen ExAC gnomAD
rs1038017615 CA348981760	804	T>K		No	ClinGen TOPMed gnomAD
rs1038017615 CA59608694	804	T>M		No	ClinGen TOPMed gnomAD
CA348981757 rs1575806401	804	T>S		No	ClinGen Ensembl
CA348981783 rs1231992823	808	P>S		No	ClinGen gnomAD
CA348981812 rs1575806580	812	W>G		No	ClinGen Ensembl
rs1575806620 CA348981828	814	V>G		No	ClinGen Ensembl
rs955265697 CA59608703	814	V>I		No	ClinGen TOPMed gnomAD
rs763108576 CA1931665	816	A>V		No	ClinGen ExAC gnomAD
rs1434028625 CA348981870	821	A>T		No	ClinGen gnomAD
rs774666561 CA1931667	823	L>P		No	ClinGen ExAC gnomAD
TCGA novel	823	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	829	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs932651402 CA59608723	837	V>D		No	ClinGen TOPMed
rs759933033 CA1931668	837	V>L		No	ClinGen ExAC gnomAD
rs1174744776 CA348981982	838	I>V		No	ClinGen TOPMed
rs1301711506 CA348982005	841	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	843	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	844	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs988094537 CA59608729	845	K>R		No	ClinGen Ensembl
TCGA novel	857	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1234504928 CA348982480	858	M>V		No	ClinGen TOPMed
rs758094896 CA1931680	861	V>L		No	ClinGen ExAC gnomAD
TCGA novel CA348982511 rs1227259523	862	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA348982505 rs1575837159	862	M>L		No	ClinGen Ensembl
CA348982520 rs1334988200	864	G>S		No	ClinGen gnomAD
CA348982526 rs1234577392	865	V>I		No	ClinGen gnomAD
CA348982527 rs1234577392	865	V>L		No	ClinGen gnomAD
rs1575837348 CA348982541	867	S>P		No	ClinGen Ensembl
rs1575837386 CA348982546	868	I>L		No	ClinGen Ensembl
rs1205528954 CA348982551	868	I>M		No	ClinGen gnomAD
rs369582743 CA59612380	868	I>T		No	ClinGen ESP
rs1263514300 CA348982560	869	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1290869648 CA348982552	869	M>L		No	ClinGen TOPMed
CA348982557 rs1575837483	869	M>R		No	ClinGen Ensembl
rs1575837528 CA348982566	870	G>A		No	ClinGen Ensembl
rs1445215746 CA348982584	873	W>*		No	ClinGen gnomAD
rs768523562 CA1931683	877	A>G		No	ClinGen ExAC gnomAD
CA348982607 rs1192467142	877	A>T		No	ClinGen gnomAD
CA1931684 rs781194498	878	T>P		No	ClinGen ExAC gnomAD
rs749289079 CA1931685	883	T>S		No	ClinGen ExAC gnomAD
CA348982676 rs1397490731	883	T>S		No	ClinGen TOPMed
rs921995823 CA59612412	892	S>T		No	ClinGen gnomAD
CA348982834 rs1383166604	894	C>R		No	ClinGen gnomAD
CA348982867 rs1335514018	895	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA59612428 rs988040254	896	A>S		No	ClinGen Ensembl
rs1475522275 CA348982894	897	P>L		No	ClinGen TOPMed
rs543195068 CA1931691	902	K>Q		No	ClinGen 1000Genomes ExAC
CA1931693 rs531982750	905	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs761176181 CA1931694	907	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	913	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	913	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1043263245 CA59612466	914	L>I		No	ClinGen gnomAD
TCGA novel	919	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931697 rs758040108	921	G>S		No	ClinGen ExAC gnomAD
rs1559627732 CA348983939	938	L>R		No	ClinGen Ensembl
rs1042287656 CA59613337	939	Y>C		No	ClinGen Ensembl
rs1559627796 CA348983971	941	V>M		No	ClinGen Ensembl
TCGA novel	943	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348984006 rs1232276631	944	Y>F		No	ClinGen TOPMed
rs762348408 CA1931711	945	M>I		No	ClinGen ExAC gnomAD
CA348984030 rs1300027189	946	G>S		No	ClinGen gnomAD
rs1370425233 CA348984046	947	A>V		No	ClinGen TOPMed
rs1446564035 CA348984052	948	S>P		No	ClinGen gnomAD
TCGA novel	950	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372522554 CA1931723	956	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1283303387 CA348984319	958	R>K		No	ClinGen TOPMed
CA348984326 rs1453021414 CA348984324	959	I>L		No	ClinGen gnomAD
rs1215184645 CA348984329	959	I>T		No	ClinGen TOPMed
rs1193367978 CA348984334	960	K>T		No	ClinGen gnomAD
rs1420884778 CA348984346	962	F>L		No	ClinGen TOPMed gnomAD
rs1430760379 CA348984360	963	W>C		No	ClinGen gnomAD
TCGA novel	964	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348984380 rs1464645799	966	A>E		No	ClinGen gnomAD
rs141608873 CA1931725	966	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs990035795 CA59616660	971	D>G		No	ClinGen TOPMed
rs763081846 CA59616664	973	I>V		No	ClinGen Ensembl
TCGA novel	974	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931727 rs747209025	974	Y>H		No	ClinGen ExAC
rs376606282 CA59616668	977	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA348984525 rs1438490047	978	V>I		No	ClinGen gnomAD
CA348984547 rs1324919673	979	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1931730 rs748518515	981	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1931731 rs770277093	982	K>E		No	ClinGen ExAC gnomAD
CA348984574 rs1420314237	984	H>P		No	ClinGen TOPMed
rs1420314237 CA348984575	984	H>R		No	ClinGen TOPMed
rs762401842 CA1931733	987	T>S		No	ClinGen ExAC gnomAD
TCGA novel	990	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1931735 rs773893991	994	L>F		No	ClinGen ExAC gnomAD
CA1931736 rs759225760	995	G>S		No	ClinGen ExAC gnomAD
CA1931738 rs767136316	999	I>L		No	ClinGen ExAC gnomAD
rs1367646507 CA348984679	999	I>T		No	ClinGen TOPMed
rs767136316 CA1931737	999	I>V		No	ClinGen ExAC gnomAD
CA348984710 rs1425214729	1004	R>G		No	ClinGen TOPMed
CA348984716 rs1575880923	1004	R>S		No	ClinGen Ensembl
TCGA novel	1005	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1487137813 CA348984730	1007	I>V		No	ClinGen gnomAD
rs764080216 CA1931740	1011	M>I		No	ClinGen ExAC gnomAD
CA348984813 rs1375759363	1015	A>T		No	ClinGen gnomAD
rs1349241951 CA348985029	1026	L>*		No	ClinGen gnomAD
rs778147754	1026	L>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1213730217 CA348985062	1028	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA348985089 rs1208782347	1030	R>Q		No	ClinGen gnomAD
rs781426592 CA1931765	1030	R>W		No	ClinGen ExAC gnomAD
rs1233137183 CA348985109	1031	E>D		No	ClinGen gnomAD
CA348985208 rs1470932753	1037	D>Y		No	ClinGen gnomAD
rs756370402 CA1931767	1039	M>T		No	ClinGen ExAC
CA348985246 rs1452909370	1039	M>V		No	ClinGen gnomAD
rs1254693801 COSM1590875 COSM1008320 CA348985288	1041	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1373530788 CA348985385	1044	K>I		No	ClinGen gnomAD
CA59617328 rs768286292	1047	L>M		No	ClinGen Ensembl
rs1329575832 CA348985534	1053	E>K		No	ClinGen gnomAD
CA348986114 rs1419729826	1054	E>G		No	ClinGen TOPMed
rs12991239 CA59621586	1055	E>*		No	ClinGen Ensembl
CA1931787 RCV000518166 rs142943771	1056	Q>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs779430605 CA1931788	1056	Q>R		No	ClinGen ExAC gnomAD
CA348986142 rs1193887507	1057	S>R		No	ClinGen gnomAD
rs1474491390 CA348986157	1058	M>V		No	ClinGen gnomAD
CA1931790 rs539417260	1059	L>Q		No	ClinGen ExAC gnomAD
rs1233292118 CA348986186	1060	A>D		No	ClinGen TOPMed gnomAD
CA348986181 rs1463159646	1060	A>S		No	ClinGen TOPMed gnomAD
rs1463159646 CA348986178	1060	A>T		No	ClinGen TOPMed gnomAD
RCV000518753 rs779428686 CA1931791	1061	M>I		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA348986189 rs1477639207	1061	M>V		No	ClinGen gnomAD
CA1931792 rs574637617	1062	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs199904335 CA59621602	1064	E>D		No	ClinGen Ensembl
rs368433654 CA1931793	1064	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1931794 rs776429077	1065	G>S		No	ClinGen ExAC TOPMed gnomAD
rs769688923 CA1931796	1068	Q>L		No	ClinGen ExAC gnomAD
CA348986276 rs1355709918	1069	L>I		No	ClinGen gnomAD
rs773098267 CA1931797	1070	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
TCGA novel	1070	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1308315817 CA348986350	1075	Y>C		No	ClinGen TOPMed
rs201485344 CA1931800	1075	Y>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348986360 rs182913811	1076	R>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1931801 rs182913811	1076	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764141107 CA348986410	1077	D>G		No	ClinGen ExAC TOPMed gnomAD
rs764141107 CA1931820	1077	D>V		No	ClinGen ExAC TOPMed gnomAD
CA348986426 rs1184443597	1078	D>E		No	ClinGen gnomAD
rs776736280 CA1931821	1080	S>P		No	ClinGen ExAC gnomAD
CA1931822 rs762021266	1081	V>A		No	ClinGen ExAC gnomAD
rs1377767755 CA348986545	1087	E>V		No	ClinGen gnomAD
CA1931823 rs765555878	1088	M>I		No	ClinGen ExAC gnomAD
CA348986552 rs1575967475	1088	M>L		No	ClinGen Ensembl
rs375704779 CA1931824	1089	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA348986603 rs1391546956	1091	T>N		No	ClinGen gnomAD
rs752130013 CA59622672	1092	A>D		No	ClinGen gnomAD
rs766757048 CA1931826	1092	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM1008322 CA348986623 rs1239128781 COSM1153505	1093	L>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1931828 rs755581680	1094	W>*		No	ClinGen ExAC gnomAD
rs1559672560 CA348986630	1094	W>R		No	ClinGen Ensembl
rs945358446 CA59622697	1095	R>G		No	ClinGen gnomAD
CA348986693 rs747717169	1096	N>K		No	ClinGen ExAC TOPMed gnomAD
rs780845109 CA1931829	1096	N>S		No	ClinGen ExAC gnomAD
CA1931831 rs763424422	1097	L>R		No	ClinGen ExAC TOPMed gnomAD
CA348986712 rs1236558772	1098	L>V		No	ClinGen gnomAD
rs1457632780 CA348986733	1100	T>P		No	ClinGen gnomAD
CA348986740 rs1575968065	1100	T>S		No	ClinGen Ensembl
CA1931832 rs777483594	1101	A>D		No	ClinGen ExAC gnomAD
TCGA novel	1101	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348986760 COSM3391037 COSM3391039 COSM3391038 rs1393751149	1102	D>N	pancreas skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1376645949 CA348986801	1105	K>E		No	ClinGen gnomAD
CA1931835 rs774176000	1105	K>R		No	ClinGen ExAC gnomAD
COSM126270 CA348986822 rs1299573953	1106	D>N	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1397631787 CA348986843	1107	K>E		No	ClinGen gnomAD
rs745777704 CA1931837	1107	K>M		No	ClinGen ExAC gnomAD
rs745777704 CA1931836	1107	K>R		No	ClinGen ExAC gnomAD
CA1931838 rs776681349	1108	E>G		No	ClinGen ExAC TOPMed gnomAD
CA348986896 rs1384937691	1110	S>G		No	ClinGen gnomAD
CA59622762 rs1051999705	1110	S>N		No	ClinGen TOPMed
CA348986917 rs1300497563	1111	F>L		No	ClinGen gnomAD
rs376785780 CA59622767	1113	S>Y		No	ClinGen Ensembl
COSM717238 rs1308079048 COSM1647097 COSM1148356 CA348987150	1116	S>F	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1276352355 CA537103025	1119	S>Y		No	ClinGen TOPMed gnomAD

No associated diseases with Q6U841

8 regional properties for Q6U841

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	436 - 517	IPR001680-1
repeat	WD40 repeat	561 - 603	IPR001680-2
repeat	WD40 repeat	606 - 644	IPR001680-3
repeat	WD40 repeat	647 - 686	IPR001680-4
repeat	WD40 repeat	690 - 729	IPR001680-5
repeat	WD40 repeat	741 - 784	IPR001680-6
domain	BOP1, N-terminal domain	171 - 436	IPR012953
conserved_site	WD40 repeat, conserved site	462 - 476	IPR019775

Functions

		Description
EC Number
Subcellular Localization	Basolateral cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Cell projection, dendrite Cell projection, axon Perikaryon Presynapse Postsynapse	Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells In amacrine cells, located in the perikaryon Also detected in basal and apical dendrites of hippocampal pyramidal cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
apical dendrite	A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
basal dendrite	A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
CA3 pyramidal cell dendrite	A dendrite of a hippocampal CA3 pyramidal cell.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse	The part of a synapse that is part of the post-synaptic cell.
somatodendritic compartment	The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name	Definition
sodium:bicarbonate symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
solute:inorganic anion antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

14 GO annotations of biological process

Name	Definition
bicarbonate transport	The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
brain morphogenesis	The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
chloride transport	The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ion homeostasis	Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
locomotory exploration behavior	The specific movement from place to place of an organism in response to a novel environment.
multicellular organism growth	The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
post-embryonic development	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
proton transmembrane transport	The directed movement of a proton across a membrane.
pyramidal neuron development	The progression of a pyramidal neuron from its initial formation to its mature state.
regulation of intracellular pH	Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
regulation of short-term neuronal synaptic plasticity	A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
response to light stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

24 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9GL77	SLC4A4	Electrogenic sodium bicarbonate cotransporter 1	Bos taurus (Bovine)	PR
Q32LP4	SLC4A10	Sodium-driven chloride bicarbonate exchanger	Bos taurus (Bovine)	PR
Q8NBS3	SLC4A11	Solute carrier family 4 member 11	Homo sapiens (Human)	PR
Q9Y6R1	SLC4A4	Electrogenic sodium bicarbonate cotransporter 1	Homo sapiens (Human)	PR
Q9Y6M7	SLC4A7	Sodium bicarbonate cotransporter 3	Homo sapiens (Human)	PR
Q2Y0W8	SLC4A8	Electroneutral sodium bicarbonate exchanger 1	Homo sapiens (Human)	PR
P02730	SLC4A1	Band 3 anion transport protein	Homo sapiens (Human)	PR
P04920	SLC4A2	Anion exchange protein 2	Homo sapiens (Human)	PR
P04919	Slc4a1	Band 3 anion transport protein	Mus musculus (Mouse)	PR
Q8JZR6	Slc4a8	Electroneutral sodium bicarbonate exchanger 1	Mus musculus (Mouse)	PR
Q8BTY2	Slc4a7	Sodium bicarbonate cotransporter 3	Mus musculus (Mouse)	PR
P13808	Slc4a2	Anion exchange protein 2	Mus musculus (Mouse)	PR
A2AJN7	Slc4a11	Solute carrier family 4 member 11	Mus musculus (Mouse)	PR
P16283	Slc4a3	Anion exchange protein 3	Mus musculus (Mouse)	PR
O88343	Slc4a4	Electrogenic sodium bicarbonate cotransporter 1	Mus musculus (Mouse)	PR
Q5DTL9	Slc4a10	Sodium-driven chloride bicarbonate exchanger	Mus musculus (Mouse)	PR
Q4U116	SLC4A4	Electrogenic sodium bicarbonate cotransporter 1	Sus scrofa (Pig)	PR
Q9JI66	Slc4a4	Electrogenic sodium bicarbonate cotransporter 1	Rattus norvegicus (Rat)	PR
Q9R1N3	Slc4a7	Sodium bicarbonate cotransporter 3	Rattus norvegicus (Rat)	PR
Q80ZA5	Slc4a10	Sodium-driven chloride bicarbonate exchanger	Rattus norvegicus (Rat)	PR
Q3E954	BOR6	Probable boron transporter 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M1P7	BOR2	Probable boron transporter 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SUU1	BOR7	Probable boron transporter 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8VYR7	BOR1	Boron transporter 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MEIKDQGAQM	EPLLPTRNDE	EAVVDRGGTR	SILKTHFEKE	DLEGHRTLFI	GVHVPLGGRK
70	80	90	100	110	120
SHRRHRHRGH	KHRKRDRERD	SGLEDGRESP	SFDTPSQRVQ	FILGTEDDDE	EHIPHDLFTE
130	140	150	160	170	180
LDEICWREGE	DAEWRETARW	LKFEEDVEDG	GERWSKPYVA	TLSLHSLFEL	RSCILNGTVL
190	200	210	220	230	240
LDMHANTLEE	IADMVLDQQV	SSGQLNEDVR	HRVHEALMKQ	HHHQNQKKLT	NRIPIVRSFA
250	260	270	280	290	300
DIGKKQSEPN	SMDKNAGQVV	SPQSAPACVE	NKNDVSRENS	TVDFSKGLGG	QQKGHTSPCG
310	320	330	340	350	360
MKQRHEKGPP	HQQEREVDLH	FMKKIPPGAE	ASNILVGELE	FLDRTVVAFV	RLSPAVLLQG
370	380	390	400	410	420
LAEVPIPTRF	LFILLGPLGK	GQQYHEIGRS	IATLMTDEVF	HDVAYKAKDR	NDLVSGIDEF
430	440	450	460	470	480
LDQVTVLPPG	EWDPSIRIEP	PKNVPSQEKR	KIPAVPNGTA	AHGEAEPHGG	HSGPELQRTG
490	500	510	520	530	540
RIFGGLILDI	KRKAPYFWSD	FRDAFSLQCL	ASFLFLYCAC	MSPVITFGGL	LGEATEGRIS
550	560	570	580	590	600
AIESLFGASM	TGIAYSLFGG	QPLTILGSTG	PVLVFEKILF	KFCKEYGLSY	LSLRASIGLW
610	620	630	640	650	660
TATLCIILVA	TDASSLVCYI	TRFTEEAFAS	LICIIFIYEA	LEKLFELSEA	YPINMHNDLE
670	680	690	700	710	720
LLTQYSCNCV	EPHNPSNGTL	KEWRESNISA	SDIIWENLTV	SECKSLHGEY	VGRACGHDHP
730	740	750	760	770	780
YVPDVLFWSV	ILFFSTVTLS	ATLKQFKTSR	YFPTKVRSIV	SDFAVFLTIL	CMVLIDYAIG
790	800	810	820	830	840
IPSPKLQVPS	VFKPTRDDRG	WFVTPLGPNP	WWTVIAAIIP	ALLCTILIFM	DQQITAVIIN
850	860	870	880	890	900
RKEHKLKKGC	GYHLDLLMVA	VMLGVCSIMG	LPWFVAATVL	SITHVNSLKL	ESECSAPGEQ
910	920	930	940	950	960
PKFLGIREQR	VTGLMIFILM	GSSVFMTSIL	KFIPMPVLYG	VFLYMGASSL	KGIQFFDRIK
970	980	990	1000	1010	1020
LFWMPAKHQP	DFIYLRHVPL	RKVHLFTIIQ	MSCLGLLWII	KVSRAAIVFP	MMVLALVFVR
1030	1040	1050	1060	1070	1080
KLMDLLFTKR	ELSWLDDLMP	ESKKKKLEDA	EKEEEQSMLA	MEDEGTVQLP	LEGHYRDDPS
1090	1100	1110
VINISDEMSK	TALWRNLLIT	ADNSKDKESS	FPSKSSPS