Q8JZR6
PR
Gene name |
Slc4a8 |
Protein name |
Electroneutral sodium bicarbonate exchanger 1 |
Names |
Electroneutral Na+-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:59033 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8JZR6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8JZR6-F1 | Predicted | AlphaFoldDB |
50 variants for Q8JZR6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3406235719 | 77 | G>C | No | EVA | |
| rs3406483470 | 131 | A>D | No | EVA | |
| rs3406235739 | 138 | R>W | No | EVA | |
| rs3389385389 | 171 | S>I | No | EVA | |
| rs3389385088 | 177 | S>Y | No | EVA | |
| rs3389407843 | 185 | S>R | No | EVA | |
| rs3389360394 | 186 | S>G | No | EVA | |
| rs3389353136 | 249 | H>Y | No | EVA | |
| rs3389388884 | 335 | T>S | No | EVA | |
| rs3389390435 | 365 | E>* | No | EVA | |
| rs3405690833 | 392 | T>A | No | EVA | |
| rs3389385089 | 394 | L>F | No | EVA | |
| rs3389385089 | 394 | L>V | No | EVA | |
| rs3389353096 | 412 | P>L | No | EVA | |
| rs3406408368 | 413 | S>Y | No | EVA | |
| rs3389385072 | 415 | E>K | No | EVA | |
| rs3389341516 | 420 | P>A | No | EVA | |
| rs3406408400 | 471 | A>T | No | EVA | |
| rs3389385349 | 486 | A>V | No | EVA | |
| rs3389388898 | 545 | I>N | No | EVA | |
| rs3389353130 | 548 | K>N | No | EVA | |
| rs3389396551 | 564 | I>V | No | EVA | |
| rs3389385042 | 585 | C>R | No | EVA | |
| rs582276466 | 618 | Y>F | No | EVA | |
| rs249747072 | 622 | M>K | No | EVA | |
| rs249747072 | 622 | M>T | No | EVA | |
| rs3389396602 | 636 | C>S | No | EVA | |
| rs3389360387 | 640 | E>D | No | EVA | |
| rs3389385383 | 643 | N>K | No | EVA | |
| rs233707124 | 663 | A>G | No | EVA | |
| rs3389385079 | 676 | E>G | No | EVA | |
| rs3389307859 | 722 | R>M | No | EVA | |
| rs3389307943 | 747 | G>S | No | EVA | |
| rs3389389996 | 761 | P>S | No | EVA | |
| rs3389388901 | 769 | F>L | No | EVA | |
| rs3389385320 | 813 | L>F | No | EVA | |
| rs3389385020 | 849 | I>F | No | EVA | |
| rs3389341475 | 865 | G>R | No | EVA | |
| rs3389307863 | 908 | V>D | No | EVA | |
| rs3406613011 | 942 | L>Q | No | EVA | |
| rs3406636830 | 951 | H>D | No | EVA | |
| rs3389393195 | 997 | R>H | No | EVA | |
| rs3389385076 | 1001 | W>R | No | EVA | |
| rs263467639 | 1030 | D>G | No | EVA | |
| rs3389391926 | 1038 | L>R | No | EVA | |
| rs3389393170 | 1061 | N>D | No | EVA | |
| rs3389389940 | 1061 | N>I | No | EVA | |
| rs3389385337 | 1064 | D>Y | No | EVA | |
| rs3389389942 | 1065 | E>Q | No | EVA | |
| rs3389381147 | 1078 | N>D | No | EVA |
No associated diseases with Q8JZR6
Functions
16 GO annotations of cellular component
| Name | Definition |
|---|---|
| asymmetric synapse | A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. |
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glial cell projection | A prolongation or process extending from a glial cell. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| hippocampal mossy fiber | Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| symmetric synapse | A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| terminal bouton | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| sodium ion transmembrane transporter activity | Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. |
| sodium:bicarbonate symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| modulation of chemical synaptic transmission | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. |
| positive regulation of synaptic vesicle exocytosis | Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAGSNEPDG | VLSYQRPDEE | AVVDQGGTST | ILNIHYEKEE | LEGHRTLYVG | VRMPLGRQSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RHHRTHGQKH | RRRGGRGKGA | SQGEEGLEAL | AHDTPSQRVQ | FILGTEEDEE | HVPHELFTEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DEICMKEGED | AEWKETARWL | KFEEDVEDGG | ERWSKPYVAT | LSLHSLFELR | SCLINGSVLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DMRASSIEEI | SDLILDQQEL | LRDLSDSVRV | KVREALLKKH | HHQNERRRNN | LIPIVRSFAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VGKKQSDPHS | MDRDGQTVSP | QSATNLEVKN | GVNCEHSPVD | LSKVDLHFMK | KIPTGAEASN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLVGEVDTLD | RPIVAFVRLS | PAVLLSGLTE | VPIPTRFLFI | LLGPVGKGQQ | YHEIGRSMAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IMTDEIFHDV | AYKAKERDDL | LAGIDEFLDQ | VTVLPPGEWD | PSIRIEPPKN | VPSQEKRKMP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GVPNGNVCHI | EPEPHGGHSG | PELERTGRLF | GGLVLDVKRK | APWYWSDYRD | ALSLQCLASF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFLYCACMSP | VITFGGLLGE | ATEGRISAIE | SLFGASMTGI | AYSLFAGQPL | TILGSTGPVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VFEKILFKFC | KDYALSYLSL | RALIGLWTAF | LCIVLVATDA | SSLVCYITRF | TEEAFASLIC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IIFIYEAIEK | LIHLAETYPI | HMHSQLDHLS | LYYCRCVLPE | NPNNHTLQYW | KDHNILAAEV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NWANLTVSEC | QEMHGEFMGS | ACGHHGPYTP | DVLFWSCILF | FATFIVSSTL | KTFKTSRYFP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TRVRSMVSDF | AVFLTIFTMV | VLDFLIGVPS | PKLQVPNVFK | PTRDDRGWFI | NPIGPNPWWT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VIAAIIPALL | CTILIFMDQQ | ITAVIINRKE | HKLKKGCGYH | LDLLMVAVML | GVCSIMGLPW |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FVAATVLSIT | HVNSLKLESE | CSAPGEQPKF | LGIREQRVTG | LMIFVLMGCS | VFMTAVLKFI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PMPVLYGVFL | YMGVSSLQGI | QFFDRLKLFG | MPAKHQPDFI | YLRHVPLRKV | HLFTLVQLTC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LVLLWVIKAS | PAAIVFPMMV | LALVFVRKVM | DLCFSKRELS | WLDDLMPESK | KKKLDDAKKK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EEEEAEKMLD | IGGDKFPLES | RKLLSSPGKS | SSFRCDPSEI | NISDEMPKTT | VWKALSINSG |
| NTKEKSPFN |