O88343
PR
Gene name |
Slc4a4 (Nbc1, Nbce1) |
Protein name |
Electrogenic sodium bicarbonate cotransporter 1 |
Names |
Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54403 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88343
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88343-F1 | Predicted | AlphaFoldDB |
41 variants for O88343
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3395614710 | 7 | L>Q | No | EVA | |
| rs3395868827 | 13 | F>S | No | EVA | |
| rs3388757269 | 69 | D>E | No | EVA | |
| rs3388768189 | 69 | D>H | No | EVA | |
| rs3388769670 | 69 | D>V | No | EVA | |
| rs3388775373 | 75 | E>D | No | EVA | |
| rs3388765752 | 101 | D>V | No | EVA | |
| rs3388764283 | 102 | S>G | No | EVA | |
| rs3413135524 | 209 | L>F | No | EVA | |
| rs3388773187 | 227 | I>N | No | EVA | |
| rs3388768139 | 233 | S>R | No | EVA | |
| rs3388773205 | 347 | L>F | No | EVA | |
| rs3388773172 | 404 | K>* | No | EVA | |
| rs257084565 | 412 | N>H | No | EVA | |
| rs3388761964 | 423 | G>* | No | EVA | |
| rs3388764372 | 455 | P>S | No | EVA | |
| rs3388768591 | 481 | V>L | No | EVA | |
| rs3388761560 | 491 | L>V | No | EVA | |
| rs3388773230 | 509 | A>T | No | EVA | |
| rs3388765771 | 539 | L>P | No | EVA | |
| rs3395177279 | 604 | M>V | No | EVA | |
| rs1134101119 | 655 | S>Y | No | EVA | |
| rs3388761540 | 698 | I>N | No | EVA | |
| rs3388757308 | 722 | T>P | No | EVA | |
| rs3388764320 | 732 | I>F | No | EVA | |
| rs3388768585 | 734 | L>V | No | EVA | |
| rs3388770837 | 736 | I>N | No | EVA | |
| rs3388768154 | 738 | I>M | No | EVA | |
| rs3388775445 | 751 | P>S | No | EVA | |
| rs3395813887 | 752 | K>L | No | EVA | |
| rs3388764363 | 752 | K>N | No | EVA | |
| rs3388768599 | 790 | L>I | No | EVA | |
| rs3395483594 | 816 | G>E | No | EVA | |
| rs3388768149 | 848 | S>F | No | EVA | |
| rs3388761942 | 904 | V>M | No | EVA | |
| rs3388754897 | 920 | V>M | No | EVA | |
| rs3388770901 | 985 | A>S | No | EVA | |
| rs3388770901 | 985 | A>T | No | EVA | |
| rs3388773185 | 1022 | K>R | No | EVA | |
| rs3388768565 | 1029 | S>G | No | EVA | |
| rs3388768547 | 1038 | Y>* | No | EVA |
No associated diseases with O88343
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| sodium:bicarbonate symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| positive regulation of glycolytic process | Any process that activates or increases the frequency, rate or extent of glycolysis. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| sodium ion export across plasma membrane | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P16283 | Slc4a3 | Anion exchange protein 3 | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDEAVLDRG | ASFLKHVCDE | EEVEGHHTIY | IGVHVPKSYR | RRRRHKRKAG | HKEKKEKERI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SENYSDKSDV | ENADESSSSI | LKPLISPAAE | RIRFILGEED | DSPAPPQLFT | ELDELLAVDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEMEWKETAR | WIKFEEKVEQ | GGERWSKPHV | ATLSLHSLFE | LRTCMEKGSI | MLDREASSLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLVEMIADHQ | IETGLLKPDL | KDKVTYTLLR | KHRHQTKKSN | LRSLADIGKT | VSSASRMFSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PDNGSPAMTH | RNLTSSSLND | ISDKPEKDQL | KNKFMKKLPR | DAEASNVLVG | EVDFLDTPFI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFVRLQQAVM | LGALTEVPVP | TRFLFILLGP | KGKAKSYHEI | GRAIATLMSD | EVFHDIAYKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KDRHDLIAGI | DEFLDEVIVL | PPGEWDPTIR | IEPPKSLPSS | DKRKNMYSGG | ENVQMNGDTP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HDGGHGGGGH | GDCEELQRTG | RFCGGLIKDI | KRKAPFFASD | FYDALNIQAL | SAILFIYLAT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VTNAITFGGL | LGDATDNMQG | VLESFLGTAV | SGAIFCLFAG | QPLTILSSTG | PVLVFERLLF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NFSKDHNFDY | LEFRLWIGLW | SAFMCLVLVA | TDASFLVQYF | TRFTEEGFSS | LISFIFIYDA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FKKMIKLADY | YPINSDFKVG | YNTHFSCACL | PPDPVNLSVS | NDTTLAPEDL | PTISSTDMYH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NVTFDWAYLS | KKECVKYGGK | LVGNNCDFVP | DITLMSFILF | LGTYTSSMAM | KKFKTSRYFP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TTARKLISDF | AIILSILIFC | VIDALVGVDT | PKLIVPSEFK | PTSPNRGWFV | PPFGGNPWWV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CLAAAIPALL | VTILIFMDQQ | ITAVIVNRKE | HKLKKGAGYH | LDLFWVAILM | VVCSFMALPW |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YVAATVISIA | HIDSLKMETE | TSAPGEQPKF | LGVREQRVTG | TLVFILTGLS | VFMAPILKFI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PMPVLYGVFL | YMGVASLNGV | QFMDRLKLLL | MPLKHQPDFI | YLRHVPLRRV | HLFTFLQVLC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LALLWILKST | VAAIIFPVMI | LALVAVRKGM | DYLFSQHDLS | FLDDVIPEKD | KKKKEDEKKK |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| KKKKGSLDSD | NDDSDCPYSE | KVPSIKIPMD | IMEQQPFLSD | NKPLDRERSS | TFLERHTSC |