P16283
PR
Gene name |
Slc4a3 (Ae3) |
Protein name |
Anion exchange protein 3 |
Names |
AE 3, Anion exchanger 3, Neuronal band 3-like protein, Solute carrier family 4 member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20536 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P16283
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P16283-F1 | Predicted | AlphaFoldDB |
53 variants for P16283
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388480490 | 17 | Q>H | No | EVA | |
| rs3388480106 | 31 | V>I | No | EVA | |
| rs3388480888 | 84 | P>S | No | EVA | |
| rs3388481363 | 160 | P>L | No | EVA | |
| rs3413154608 | 160 | P>S | No | EVA | |
| rs3388482032 | 162 | Q>* | No | EVA | |
| rs3388482469 | 177 | G>C | No | EVA | |
| rs3388479619 | 180 | V>L | No | EVA | |
| rs3388483240 | 201 | R>H | No | EVA | |
| rs3388483159 | 206 | P>L | No | EVA | |
| rs3388483265 | 213 | S>P | No | EVA | |
| rs3388481337 | 215 | I>T | No | EVA | |
| rs3388482491 | 239 | S>N | No | EVA | |
| rs3388480750 | 289 | R>P | No | EVA | |
| rs3388480253 | 294 | R>K | No | EVA | |
| rs3388481090 | 312 | K>N | No | EVA | |
| rs3388483250 | 335 | P>A | No | EVA | |
| rs3388483352 | 407 | Q>* | No | EVA | |
| rs3388480137 | 410 | P>L | No | EVA | |
| rs3388481038 | 415 | S>N | No | EVA | |
| rs3388482357 | 435 | F>L | No | EVA | |
| rs3388481289 | 483 | D>Y | No | EVA | |
| rs3388481191 | 509 | P>R | No | EVA | |
| rs3388483203 | 570 | L>* | No | EVA | |
| rs3388480992 | 574 | I>F | No | EVA | |
| rs3390204933 | 598 | G>A | No | EVA | |
| rs3390206081 | 601 | S>T | No | EVA | |
| rs3390206112 | 613 | S>* | No | EVA | |
| rs3390186844 | 614 | E>* | No | EVA | |
| rs3390186819 | 616 | E>G | No | EVA | |
| rs3388479848 | 637 | E>D | No | EVA | |
| rs3388480779 | 668 | T>I | No | EVA | |
| rs3388483234 | 670 | E>D | No | EVA | |
| rs3388480489 | 681 | F>L | No | EVA | |
| rs3388481284 | 714 | I>F | No | EVA | |
| rs3388481422 | 719 | L>F | No | EVA | |
| rs3388483277 | 720 | S>T | No | EVA | |
| rs3388481228 | 748 | V>M | No | EVA | |
| rs3388481525 | 759 | Q>L | No | EVA | |
| rs3388482455 | 774 | E>D | No | EVA | |
| rs258786378 | 860 | A>V | No | EVA | |
| rs3388480237 | 886 | N>Y | No | EVA | |
| rs3388481254 | 895 | M>K | No | EVA | |
| rs3388482427 | 908 | F>S | No | EVA | |
| rs3388481031 | 944 | T>I | No | EVA | |
| rs3388481923 | 960 | P>L | No | EVA | |
| rs3388481538 | 1018 | G>A | No | EVA | |
| rs3388480477 | 1031 | G>C | No | EVA | |
| rs3388480990 | 1080 | G>E | No | EVA | |
| rs3388481331 | 1085 | S>I | No | EVA | |
| rs3388480166 | 1137 | P>T | No | EVA | |
| rs3390193181 | 1173 | S>A | No | EVA | |
| rs3388481194 | 1194 | L>P | No | EVA |
No associated diseases with P16283
4 regional properties for P16283
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Bicarbonate transporter-like, transmembrane domain | 680 - 1156 | IPR011531 |
| domain | Band 3 cytoplasmic domain | 349 - 617 | IPR013769 |
| conserved_site | Anion exchange, conserved site | 681 - 692 | IPR018241-1 |
| conserved_site | Anion exchange, conserved site | 828 - 842 | IPR018241-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| solute:inorganic anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cardiac conduction | Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GL77 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Bos taurus (Bovine) | PR |
| Q32LP4 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Bos taurus (Bovine) | PR |
| P02730 | SLC4A1 | Band 3 anion transport protein | Homo sapiens (Human) | PR |
| Q9Y6M7 | SLC4A7 | Sodium bicarbonate cotransporter 3 | Homo sapiens (Human) | PR |
| Q8NBS3 | SLC4A11 | Solute carrier family 4 member 11 | Homo sapiens (Human) | PR |
| Q6U841 | SLC4A10 | Sodium-driven chloride bicarbonate exchanger | Homo sapiens (Human) | PR |
| Q9Y6R1 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Homo sapiens (Human) | PR |
| Q2Y0W8 | SLC4A8 | Electroneutral sodium bicarbonate exchanger 1 | Homo sapiens (Human) | PR |
| P04920 | SLC4A2 | Anion exchange protein 2 | Homo sapiens (Human) | PR |
| A2AJN7 | Slc4a11 | Solute carrier family 4 member 11 | Mus musculus (Mouse) | PR |
| O88343 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Mus musculus (Mouse) | PR |
| Q5DTL9 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Mus musculus (Mouse) | PR |
| Q8JZR6 | Slc4a8 | Electroneutral sodium bicarbonate exchanger 1 | Mus musculus (Mouse) | PR |
| P04919 | Slc4a1 | Band 3 anion transport protein | Mus musculus (Mouse) | PR |
| P13808 | Slc4a2 | Anion exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8BTY2 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Mus musculus (Mouse) | PR |
| Q4U116 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 | Sus scrofa (Pig) | PR |
| Q9JI66 | Slc4a4 | Electrogenic sodium bicarbonate cotransporter 1 | Rattus norvegicus (Rat) | PR |
| Q9R1N3 | Slc4a7 | Sodium bicarbonate cotransporter 3 | Rattus norvegicus (Rat) | PR |
| Q80ZA5 | Slc4a10 | Sodium-driven chloride bicarbonate exchanger | Rattus norvegicus (Rat) | PR |
| Q3E954 | BOR6 | Probable boron transporter 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1P7 | BOR2 | Probable boron transporter 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUU1 | BOR7 | Probable boron transporter 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYR7 | BOR1 | Boron transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANGVIPPPG | GASPLPQVRV | PLEEPPLGPD | VEEEDDDLGK | TLAVSRFGDL | ISKTPAWDPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPSRSYSERD | FEFHRHTSHH | THHPLSARLP | PPHKLRRPPP | TSARHTRRKR | KKEKTSAPPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGTPPIQEEG | GAGAEEEEEE | EEEEEGESEA | EPVEPLPPGP | PQKAKFSIGS | DEDDSPGLPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAPCAKALPS | VGLQSDQSPQ | RSGSSPSPRA | RASRISTEKS | RPWSPSASYD | LRERLCPGSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGNPGPEQRV | PTDEAEAQML | GSADLDDMKS | HRLEDNPGVR | RHLVKKPSRI | QGGRGSPSGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| APILRRKKKK | KKLDRRPHEV | FVELNELMLD | RSQEPHWRET | ARWIKFEEDV | EEETERWGKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HVASLSFRSL | LELRRTIAQG | AALLDLEQTT | LPGIAHLVVE | TMIVSDQIRP | EDRASVLRTL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLKHSHPNDD | KDSGFFPRNP | SSSSVNSVLG | NHHPTPSHGP | DGAVPTMADD | QGEPAPLWPH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DPDAKEKPLH | MPGGDGHRGK | SLKLLEKIPE | DAEATVVLVG | CVPFLEQPAA | AFVRLSEAVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LESVLEVPVP | VRFLFVMLGP | SHTSTDYHEL | GRSIATLMSD | KLFHEAAYQA | DDRQDLLGAI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SEFLDGSIVI | PPSEVEGRDL | LRSVAAFQRE | LLRKRREREQ | TKVEMTTRGG | YAAPGKELSL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EMGGSEATSE | DDPLQRTGSV | FGGLVRDVKR | RYPHYPSDLR | DALHSQCVAA | VLFIYFAALS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PAITFGGLLG | EKTEGLMGVS | ELIVSTAVLG | VLFSLLGAQP | LLVVGFSGPL | LVFEEAFFKF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CRAQDLEYLT | GRVWVGLWLV | VFVLALVAAE | GSFLVRYISP | FTQEIFAFLI | SLIFIYETFH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KLYKVFTEHP | LLPFYPPDEA | LETGLELNSS | ALPPTEGPPG | PRNQPNTALL | SLILMLGTFL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IAFFLRKFRN | SRFLGGKARR | IIGDFGIPIS | ILVMVLVDYS | ITDTYTQKLT | VPTGLSVTSP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| HKRTWFIPPL | GSARPFPPWM | MVAAAVPALL | VLILIFMETQ | ITALIVSQKA | RRLLKGSGFH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LDLLLIGSLG | GLCGLFGLPW | LTAATVRSVT | HVNALTVMRT | AIAPGDKPQI | QEVREQRVTG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VLIASLVGLS | IVMGAVLRRI | PLAVLFGIFL | YMGVTSLSGI | QLSQRLLLIF | MPAKHHPEQP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YVTKVKTWRM | HLFTCIQLGC | IALLWVVKST | AASLAFPFLL | LLTVPLRRCL | LPRLFQDREL |
| 1210 | 1220 | ||||
| QALDSEDAEP | NFDEDGQDEY | NELHMPV |