Q9MAG3

PR
Gene name
ABCG24 (WBC25, At1g53390, F12M16.28)
Protein name
ABC transporter G family member 24
Names
ABC transporter ABCG.24, AtABCG24, Probable white-brown complex homolog protein 25, AtWBC25
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G53390
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

311-530 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MAG3

Entry ID Method Resolution Chain Position Source
AF-Q9MAG3-F1 Predicted AlphaFoldDB

54 variants for Q9MAG3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_19918216_T_C 7 L>P No 1000Genomes
tmp_1_19918215_C_G 7 L>V No 1000Genomes
ENSVATH01364735 10 M>L No 1000Genomes
tmp_1_19918785_G_T 23 W>L No 1000Genomes
ENSVATH01364740 43 V>L No 1000Genomes
tmp_1_19918925_C_G 70 R>G No 1000Genomes
ENSVATH14307168 100 R>G No 1000Genomes
tmp_1_19919682_A_T 135 Y>F No 1000Genomes
tmp_1_19919685_T_A 136 F>Y No 1000Genomes
ENSVATH13554460 169 G>V No 1000Genomes
tmp_1_19919795_G_T 173 D>Y No 1000Genomes
tmp_1_19919834_T_A 186 F>I No 1000Genomes
ENSVATH13554462 192 N>K No 1000Genomes
tmp_1_19920061_G_A 231 E>K No 1000Genomes
ENSVATH04953348 251 V>I No 1000Genomes
tmp_1_19920588_C_T 293 P>L No 1000Genomes
ENSVATH14307196 309 M>I No 1000Genomes
tmp_1_19920650_A_G 314 I>V No 1000Genomes
tmp_1_19920872_A_T 360 K>I No 1000Genomes
tmp_1_19920964_G_T 391 D>Y No 1000Genomes
tmp_1_19920986_G_C 398 R>P No 1000Genomes
ENSVATH01364745 407 A>D No 1000Genomes
tmp_1_19921079_A_C 429 E>A No 1000Genomes
tmp_1_19921084_C_T 431 H>Y No 1000Genomes
ENSVATH04953359 455 A>V No 1000Genomes
ENSVATH01364746 518 S>C No 1000Genomes
tmp_1_19921441_C_T 550 L>F No 1000Genomes
tmp_1_19921465_G_A 558 A>T No 1000Genomes
tmp_1_19921576_A_T 595 N>Y No 1000Genomes
ENSVATH13554480 615 S>C No 1000Genomes
tmp_1_19921876_C_T 695 L>F No 1000Genomes
tmp_1_19921885_G_C 698 V>L No 1000Genomes
tmp_1_19922030_A_T 716 N>Y No 1000Genomes
tmp_1_19922076_G_A 731 G>E No 1000Genomes
tmp_1_19922078_T_C 732 S>P No 1000Genomes
ENSVATH00096091 746 H>Y No 1000Genomes
tmp_1_19922177_G_A 765 V>M No 1000Genomes
ENSVATH01364749 770 N>H No 1000Genomes
ENSVATH14307198 783 M>R No 1000Genomes
ENSVATH13554483 786 K>N No 1000Genomes
ENSVATH00096092 809 G>C No 1000Genomes
ENSVATH13554484 822 R>K No 1000Genomes
tmp_1_19922447_C_G 855 P>A No 1000Genomes
tmp_1_19922466_A_T 861 Y>F No 1000Genomes
tmp_1_19922619_A_T 883 Y>F No 1000Genomes
tmp_1_19922999_A_T 972 Y>F No 1000Genomes
ENSVATH13554506 980 T>K No 1000Genomes
tmp_1_19923053_G_C 990 C>S No 1000Genomes
tmp_1_19923070_A_G 996 T>A No 1000Genomes
ENSVATH04953372 1076 Y>* No 1000Genomes
ENSVATH01364758 1091 V>I No 1000Genomes
tmp_1_19923530_C_G 1094 T>S No 1000Genomes
ENSVATH04953374 1101 V>L No 1000Genomes
tmp_1_19923573_G_T 1108 K>N No 1000Genomes

No associated diseases with Q9MAG3

4 regional properties for Q9MAG3

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 507 - 749 IPR003439
domain AAA+ ATPase domain 533 - 734 IPR003593
conserved_site ABC transporter-like, conserved site 648 - 662 IPR017871
domain ABC transporter family G domain 705 - 1109 IPR043926

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

1 GO annotations of biological process

Name Definition
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P45844 ABCG1 ATP-binding cassette sub-family G member 1 Homo sapiens (Human) PR
Q9H172 ABCG4 ATP-binding cassette sub-family G member 4 Homo sapiens (Human) PR
Q64343 Abcg1 ATP-binding cassette sub-family G member 1 Mus musculus (Mouse) PR
Q99PE8 Abcg5 ATP-binding cassette sub-family G member 5 Mus musculus (Mouse) PR
Q99PE7 Abcg5 ATP-binding cassette sub-family G member 5 Rattus norvegicus (Rat) PR
Q11180 wht-1 ABC transporter ATP-binding protein/permease wht-1 Caenorhabditis elegans PR
Q09466 wht-3 ABC transporter ATP-binding protein/permease wht-3 Caenorhabditis elegans PR
Q9M2V6 ABCG17 ABC transporter G family member 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9MAH4 ABCG10 ABC transporter G family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZR9 ABCG9 ABC transporter G family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
O81016 ABCG32 ABC transporter G family member 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUT8 ABCG33 ABC transporter G family member 33 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFH0 ABCG37 ABC transporter G family member 37 Arabidopsis thaliana (Mouse-ear cress) PR
Q7PC81 ABCG43 ABC transporter G family member 43 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GZ52 ABCG30 ABC transporter G family member 30 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNFNTSLVIM LLNLKMSVDR RNWLKHGCNL RLVILVLWLV CYVSNGQTIG DTSDFNNPAV
70 80 90 100 110 120
LPLVTQMVYR SLSNSTAALN RELGIRAKFC VKDPDADWNR AFNFSSNLNF LSSCIKKTQG
130 140 150 160 170 180
SIGKRICTAA EMKFYFNGFF NKTNNPGYLK PNVNCNLTSW VSGCEPGWGC SVDPTEQVDL
190 200 210 220 230 240
QNSKDFPERR RNCMPCCEGF FCPRGLTCMI PCPLGAHCPL ATLNKTTSLC EPYTYQLPSG
250 260 270 280 290 300
RPNHTCGGAN VWADIRSSGE VFCSAGSYCP TTTQKVPCDS GHYCRMGSTS EKPCFKLTSC
310 320 330 340 350 360
NPNTANQNMH AFGIMVIAAV STILLIIYNC SDQILTTRER RQAKSREAAV KKARAHHRWK
370 380 390 400 410 420
AAREAAKKHV SGIRAQITRT FSGKRANQDG DTNKMLGRGD SSEIDEAIDM STCSSPASSS
430 440 450 460 470 480
AAQSSYENED HAAAGSNGRA SLGIEGKRVK GQTLAKIKKT QSQIFKYAYD RIEKEKAMEQ
490 500 510 520 530 540
ENKNLTFSGI VKMATNSETR KRHLMELSFK DLTLTLKSNG KQVLRCVTGS MKPGRITAVM
550 560 570 580 590 600
GPSGAGKTSL LSALAGKAVG CKLSGLILIN GKQESIHSYK KIIGFVPQDD VVHGNLTVEE
610 620 630 640 650 660
NLWFHAKCRL PADLSKADKV LVVERIIDSL GLQAVRSSLV GTVEKRGISG GQRKRVNVGL
670 680 690 700 710 720
EMVMEPSVLF LDEPTSGLDS ASSQLLLRAL RHEALEGVNI CMVVHQPSYT LFKTFNDLVL
730 740 750 760 770 780
LAKGGLTVYH GSVNKVEEYF SGLGIHVPDR INPPDYYIDV LEGVVISMGN SGIGYKELPQ
790 800 810 820 830 840
RWMLHKGYSV PLDMRNNSAA GLETNPDLGT NSPDNAEQTF ARELWRDVKS NFRLRRDKIR
850 860 870 880 890 900
HNFLKSRDLS HRRTPSTWLQ YKYFLGRIAK QRMREAQLQA TDYLILLLAG ACLGSLIKAS
910 920 930 940 950 960
DESFGAPGYI YTIIAVSLLC KIAALRSFSL DKLHYWRESA SGMSSSACFL AKDTIDIFNI
970 980 990 1000 1010 1020
LVKPLVYLSM FYFFTNPRST FFDNYIVLVC LVYCVTGIAY ALAIFLQPST AQLFSVLLPV
1030 1040 1050 1060 1070 1080
VLTLVATQPK NSELIRIIAD LSYPKWALEA FVIGNAQKYY GVWMITRCGS LMKSGYDINK
1090 1100
WSLCIMILLL VGLTTRGVAF VGMLILQKK