Q09466

PR
Gene name
wht-3 (C16C10.12)
Protein name
ABC transporter ATP-binding protein/permease wht-3
Names
White related ABC transporter 3
Species
Caenorhabditis elegans
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09466

Entry ID Method Resolution Chain Position Source
AF-Q09466-F1 Predicted AlphaFoldDB

No variants for Q09466

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09466

No associated diseases with Q09466

4 regional properties for Q09466

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 42 - 277 IPR003439
domain AAA+ ATPase domain 66 - 357 IPR003593
domain ABC-2 type transporter, transmembrane domain 344 - 552 IPR013525
conserved_site ABC transporter-like, conserved site 180 - 194 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

1 GO annotations of biological process

Name Definition
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P45844 ABCG1 ATP-binding cassette sub-family G member 1 Homo sapiens (Human) PR
Q9H172 ABCG4 ATP-binding cassette sub-family G member 4 Homo sapiens (Human) PR
Q64343 Abcg1 ATP-binding cassette sub-family G member 1 Mus musculus (Mouse) PR
Q99PE8 Abcg5 ATP-binding cassette sub-family G member 5 Mus musculus (Mouse) PR
Q99PE7 Abcg5 ATP-binding cassette sub-family G member 5 Rattus norvegicus (Rat) PR
Q11180 wht-1 ABC transporter ATP-binding protein/permease wht-1 Caenorhabditis elegans PR
Q9MAH4 ABCG10 ABC transporter G family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2V6 ABCG17 ABC transporter G family member 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZR9 ABCG9 ABC transporter G family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9MAG3 ABCG24 ABC transporter G family member 24 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPFDLLAERK RWNAGYESID TSSQKLTEVV TPITVTWENI EVKTRKKLFS KKQKQLLNRV
70 80 90 100 110 120
SGIAKPGEMV ALMGASGAGK TTLMNVLMCR NMKGLEKNGT VKVNGTKIGK EISLISGFAQ
130 140 150 160 170 180
QQEIFIPTLT VDEYLMIQAR LRMKANKHTR RERVDEIIEM LRLQNCRDLK IGTPGLVKGI
190 200 210 220 230 240
SGGEARRLTF ACELLSNPSL LFADEPTSGL DSFMAASVVQ ILKNLANSGR TLIHQPTAEL
250 260 270 280 290 300
FFQFDKIIFL SMGKTAFMGT PHESVKFFAD CGHPIPKLFN PPEWIQSKLS VIPNNETKSR
310 320 330 340 350 360
ETIGKIIEFY EKSIIHQKSI VEIRVIATTE LPPYIENPGF FAETGALLKR ACLDVIRSPA
370 380 390 400 410 420
QMRMKLIQKV VMGLFIGSLY WQQPLDPRGV RNTNSALYFL IAELTFSTMF GIMTFMEHEL
430 440 450 460 470 480
PLIAREYHDG LFYVISYYIS RFLSYLPLFT IDGALMIVIS YWMIGLNSTW QQVAKSILIS
490 500 510 520 530 540
VLVEQSATSC GLFLACLFET TSLAIAFAVP ASGLFALLSG LYGNTNNFPV YIRWMQWTSW
550 560 570 580 590 600
CRYGFEGLVV NQWSQVDNPK WDPFYRELIL KQFSFNKDNY QLDVIGLCSI VIFFYLAGYI
ALFIRIRLSR