Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q11180
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q11180-F1 | Predicted | AlphaFoldDB |
No variants for Q11180
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q11180 | |||||
No associated diseases with Q11180
4 regional properties for Q11180
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P45844 | ABCG1 | ATP-binding cassette sub-family G member 1 | Homo sapiens (Human) | PR |
| Q9H172 | ABCG4 | ATP-binding cassette sub-family G member 4 | Homo sapiens (Human) | PR |
| Q99PE8 | Abcg5 | ATP-binding cassette sub-family G member 5 | Mus musculus (Mouse) | PR |
| Q64343 | Abcg1 | ATP-binding cassette sub-family G member 1 | Mus musculus (Mouse) | PR |
| Q99PE7 | Abcg5 | ATP-binding cassette sub-family G member 5 | Rattus norvegicus (Rat) | PR |
| Q09466 | wht-3 | ABC transporter ATP-binding protein/permease wht-3 | Caenorhabditis elegans | PR |
| Q9MAG3 | ABCG24 | ABC transporter G family member 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2V6 | ABCG17 | ABC transporter G family member 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9MAH4 | ABCG10 | ABC transporter G family member 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZR9 | ABCG9 | ABC transporter G family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHKAPISTLI | LDSLFSNMML | AEMMNDDQLE | LLKHQQTGIQ | PVVPEGCNLY | WSSLNVTGPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKPTNFVDRF | RNNMPKRRVK | EILHNVSGMA | ESGKLLAILG | SSGAGKTTLM | NVLTSRNLTN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDVQGSILID | GRRANKWKIR | EMSAFVQQHD | MFVGTMTARE | HLQFMARLRM | GDQYYSDHER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLRVEQVLTQ | MGLKKCADTV | IGIPNQLKGL | SCGEKKRLSF | ASEILTCPKI | LFCDEPTSGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DAFMAGHVVQ | ALRSLADNGM | TVIITIHQPS | SHVYSLFNNV | CLMACGRVIY | LGPGDQAVPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FEKCGYPCPA | YYNPADHLIR | TLAVIDSDRA | TSMKTISKIR | QGFLSTDLGQ | SVLAIGNANK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRAASFVTGS | DTSEKTKTFF | NQDYNASFWT | QFLALFWRSW | LTVIRDPNLL | SVRLLQILIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AFITGIVFFQ | TPVTPATIIS | INGIMFNHIR | NMNFMLQFPN | VPVITAELPI | VLRENANGVY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RTSAYFLAKN | IAELPQYIIL | PILYNTIVYW | MSGLYPNFWN | YCFASLVTIL | ITNVAISISY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVATIFANTD | VAMTILPIFV | VPIMAFGGFF | ITFDAIPSYF | KWLSSLSYFK | YGYEALAINE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WDSIKVIPEC | FNSSMTAFAL | DSCPKNGHQV | LESIDFSASH | KIFDISILFG | MFIGIRIIAY |
| 670 | |||||
| VALLIRSYNN | T |