Q8GZ52

PR
Gene name
ABCG30
Protein name
ABC transporter G family member 30
Names
ABC transporter ABCG.30, AtABCG30, Pleiotropic drug resistance protein 2, AtPDR2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GZ52

Entry ID Method Resolution Chain Position Source
AF-Q8GZ52-F1 Predicted AlphaFoldDB

175 variants for Q8GZ52

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06672976 3 Q>K No 1000Genomes
ENSVATH11770594 15 L>F No 1000Genomes
tmp_4_8680372_T_G 26 D>E No 1000Genomes
ENSVATH06672979 40 R>S No 1000Genomes
ENSVATH06672980 48 T>S No 1000Genomes
ENSVATH06672981 57 V>M No 1000Genomes
ENSVATH11770625 68 R>I No 1000Genomes
tmp_4_8680500_T_C 69 L>P No 1000Genomes
ENSVATH14200371 69 L>V No 1000Genomes
ENSVATH06672982 75 R>C No 1000Genomes
tmp_4_8680595_G_A 101 D>N No 1000Genomes
tmp_4_8680725_C_T 108 P>S No 1000Genomes
tmp_4_8680751_C_A 116 N>K No 1000Genomes
ENSVATH02839376 118 S>T No 1000Genomes
ENSVATH02839377 118 S>Y No 1000Genomes
tmp_4_8680774_A_T 124 Q>L No 1000Genomes
ENSVATH14200374 125 V>I No 1000Genomes
tmp_4_8680938_T_A 146 I>N No 1000Genomes
tmp_4_8680941_G_T 147 C>F No 1000Genomes
ENSVATH06672988 149 K>N No 1000Genomes
ENSVATH06672989 163 I>T No 1000Genomes
ENSVATH00506788 191 F>L No 1000Genomes
ENSVATH06672991 194 S>C No 1000Genomes
ENSVATH06672992 202 C>S No 1000Genomes
ENSVATH06672992 202 C>Y No 1000Genomes
ENSVATH06672993 203 Y>* No 1000Genomes
ENSVATH06672994 206 C>W No 1000Genomes
tmp_4_8681447_G_T 240 A>S No 1000Genomes
tmp_4_8681465_G_A 246 G>R No 1000Genomes
tmp_4_8681595_G_A 259 E>K No 1000Genomes
ENSVATH00506790 270 V>I No 1000Genomes
tmp_4_8681773_T_A 290 Y>N No 1000Genomes
tmp_4_8681774_A_C 290 Y>S No 1000Genomes
ENSVATH06673002 298 D>N No 1000Genomes
ENSVATH06673002 298 D>Y No 1000Genomes
ENSVATH14200381 311 P>S No 1000Genomes
ENSVATH14200382 328 V>M No 1000Genomes
ENSVATH06673003 331 A>V No 1000Genomes
tmp_4_8682072_A_G 339 I>V No 1000Genomes
tmp_4_8682084_T_G 343 L>V No 1000Genomes
tmp_4_8682097_C_G,A 347 T>N No 1000Genomes
tmp_4_8682097_C_G,A 347 T>S No 1000Genomes
tmp_4_8682112_T_G 352 V>G No 1000Genomes
tmp_4_8682120_C_T 355 L>F No 1000Genomes
tmp_4_8682124_A_G 356 Q>R No 1000Genomes
tmp_4_8682177_G_A 374 A>T No 1000Genomes
ENSVATH06673006 389 E>K No 1000Genomes
tmp_4_8682241_A_T 395 H>L No 1000Genomes
ENSVATH06673007 421 F>I No 1000Genomes
ENSVATH06673008 430 D>G No 1000Genomes
ENSVATH00506791 442 Y>* No 1000Genomes
tmp_4_8682447_A_C 443 S>R No 1000Genomes
ENSVATH14200406 444 Y>C No 1000Genomes
tmp_4_8682462_G_A 448 D>N No 1000Genomes
ENSVATH06673010 452 N>S No 1000Genomes
ENSVATH14200407 460 G>R No 1000Genomes
tmp_4_8682503_G_T 461 L>F No 1000Genomes
ENSVATH14200408 463 L>R No 1000Genomes
ENSVATH00506792 464 K>T No 1000Genomes
ENSVATH14200409 472 N>D No 1000Genomes
ENSVATH06673012 472 N>I No 1000Genomes
ENSVATH06673012 472 N>S No 1000Genomes
ENSVATH11770659 473 K>N No 1000Genomes
tmp_4_8682552_A_T 478 K>* No 1000Genomes
tmp_4_8682558_G_A 480 G>S No 1000Genomes
tmp_4_8682568_A_T 483 Y>F No 1000Genomes
tmp_4_8682571_A_G 484 K>R No 1000Genomes
tmp_4_8682603_A_G 495 K>E No 1000Genomes
ENSVATH14200410 496 A>P No 1000Genomes
ENSVATH11770660 498 S>A No 1000Genomes
ENSVATH14200411 502 F>I No 1000Genomes
tmp_4_8682670_C_G 517 A>G No 1000Genomes
ENSVATH11770661 527 M>T No 1000Genomes
tmp_4_8682795_C_T 535 A>V No 1000Genomes
ENSVATH06673015 539 S>P No 1000Genomes
ENSVATH00506793 544 Y>C No 1000Genomes
tmp_4_8682829_G_A 546 M>I No 1000Genomes
tmp_4_8682857_C_T 556 L>F No 1000Genomes
ENSVATH14200425 558 A>V No 1000Genomes
ENSVATH11770663 574 F>V No 1000Genomes
tmp_4_8682935_T_C 582 F>L No 1000Genomes
tmp_4_8682947_T_C 586 W>R No 1000Genomes
ENSVATH11770675 613 Y>N No 1000Genomes
ENSVATH11770677 634 F>C No 1000Genomes
ENSVATH11770678 650 R>S No 1000Genomes
tmp_4_8683231_C_A 651 T>K No 1000Genomes
tmp_4_8683251_A_G 658 T>A No 1000Genomes
ENSVATH06673022 662 S>F No 1000Genomes
ENSVATH11770681 686 G>R No 1000Genomes
ENSVATH11770682 717 T>A No 1000Genomes
tmp_4_8683626_C_T 717 T>I No 1000Genomes
ENSVATH06673031 723 M>I No 1000Genomes
tmp_4_8683649_G_C 725 D>H No 1000Genomes
tmp_4_8683700_G_A 742 A>T No 1000Genomes
ENSVATH00506794 757 A>V No 1000Genomes
tmp_4_8683755_A_T 760 Y>F No 1000Genomes
tmp_4_8683757_C_A 761 Q>K No 1000Genomes
tmp_4_8683857_G_A 766 R>K No 1000Genomes
tmp_4_8683868_A_T 770 I>F No 1000Genomes
tmp_4_8683919_T_A 787 C>S No 1000Genomes
ENSVATH06673036 789 K>R No 1000Genomes
tmp_4_8683935_C_T 792 S>F No 1000Genomes
ENSVATH14200428 792 S>P No 1000Genomes
ENSVATH11770698 797 G>E No 1000Genomes
ENSVATH06673038 798 K>N No 1000Genomes
ENSVATH14200431 799 I>L No 1000Genomes
tmp_4_8684228_C_T 825 R>* No 1000Genomes
ENSVATH11770702 825 R>Q No 1000Genomes
ENSVATH11770703 834 A>T No 1000Genomes
tmp_4_8684267_G_A 838 G>R No 1000Genomes
ENSVATH06673041 838 G>V No 1000Genomes
tmp_4_8684318_C_T 855 L>F No 1000Genomes
tmp_4_8684345_C_T 864 R>C No 1000Genomes
ENSVATH02839394 864 R>H No 1000Genomes
ENSVATH11770716 866 I>M No 1000Genomes
tmp_4_8684370_A_G 872 K>R No 1000Genomes
ENSVATH11770717 888 G>D No 1000Genomes
tmp_4_8684473_G_C 906 L>F No 1000Genomes
ENSVATH06673045 920 S>A No 1000Genomes
ENSVATH11770720 934 V>G No 1000Genomes
tmp_4_8684641_G_A 935 E>K No 1000Genomes
ENSVATH02839397 954 I>T No 1000Genomes
tmp_4_8684707_C_T 957 R>C No 1000Genomes
tmp_4_8684761_A_G 975 M>V No 1000Genomes
tmp_4_8684767_G_A 977 E>K No 1000Genomes
ENSVATH06673052 986 A>T No 1000Genomes
ENSVATH06673053 989 I>T No 1000Genomes
ENSVATH06673054 998 A>T No 1000Genomes
ENSVATH11770722 1030 Q>L No 1000Genomes
ENSVATH11770723 1035 G>C No 1000Genomes
ENSVATH00506796 1054 L>V No 1000Genomes
tmp_4_8685183_G_T 1059 K>N No 1000Genomes
ENSVATH02839399 1083 F>L No 1000Genomes
tmp_4_8685256_T_G 1084 S>A No 1000Genomes
tmp_4_8685259_C_T 1085 Q>* No 1000Genomes
ENSVATH11770756 1095 Q>* No 1000Genomes
ENSVATH06673066 1102 Q>E No 1000Genomes
ENSVATH11770757 1111 E>Q No 1000Genomes
tmp_4_8685497_C_A 1134 Q>K No 1000Genomes
ENSVATH14200434 1150 V>I No 1000Genomes
tmp_4_8685551_A_G,C 1152 I>L No 1000Genomes
tmp_4_8685551_A_G,C 1152 I>V No 1000Genomes
ENSVATH14200455 1153 L>* No 1000Genomes
ENSVATH06673074 1173 Q>K No 1000Genomes
ENSVATH11770775 1178 S>N No 1000Genomes
ENSVATH14200458 1183 M>I No 1000Genomes
ENSVATH06673076 1184 Y>C No 1000Genomes
tmp_4_8685865_C_T 1190 P>L No 1000Genomes
tmp_4_8685886_C_T 1197 A>V No 1000Genomes
ENSVATH06673077 1208 V>L No 1000Genomes
tmp_4_8685939_G_C 1215 A>P No 1000Genomes
ENSVATH02839403 1216 R>Q No 1000Genomes
ENSVATH02839405 1237 L>F No 1000Genomes
ENSVATH14200460 1243 T>A No 1000Genomes
ENSVATH11770778 1247 Y>N No 1000Genomes
tmp_4_8686196_G_A 1251 G>S No 1000Genomes
tmp_4_8686211_G_A 1256 V>I No 1000Genomes
tmp_4_8686222_G_T,A 1259 M>I No 1000Genomes
tmp_4_8686247_T_G 1268 C>G No 1000Genomes
ENSVATH06673082 1281 V>I No 1000Genomes
ENSVATH11770780 1284 T>K No 1000Genomes
ENSVATH02839406 1288 H>L No 1000Genomes
tmp_4_8686614_A_G 1313 K>E No 1000Genomes
tmp_4_8686634_A_G 1319 I>M No 1000Genomes
ENSVATH14200464 1326 P>L No 1000Genomes
tmp_4_8686701_G_A 1342 V>I No 1000Genomes
ENSVATH06673084 1348 V>I No 1000Genomes
ENSVATH11770796 1353 K>* No 1000Genomes
ENSVATH02839408 1356 S>P No 1000Genomes
ENSVATH02839409 1372 V>D No 1000Genomes
tmp_4_8686798_C_T 1374 A>V No 1000Genomes
ENSVATH02839410 1386 T>S No 1000Genomes
ENSVATH11770797 1389 A>P No 1000Genomes
ENSVATH00506798 1396 S>N No 1000Genomes
tmp_4_8686870_A_G 1398 Q>R No 1000Genomes

No associated diseases with Q8GZ52

11 regional properties for Q8GZ52

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 141 - 414 IPR003439-1
domain ABC transporter-like, ATP-binding domain 808 - 1053 IPR003439-2
domain AAA+ ATPase domain 166 - 391 IPR003593-1
domain AAA+ ATPase domain 837 - 1029 IPR003593-2
domain ABC-2 type transporter, transmembrane domain 494 - 704 IPR013525-1
domain ABC-2 type transporter, transmembrane domain 1126 - 1339 IPR013525-2
domain Plant PDR ABC transporter associated 709 - 771 IPR013581
domain ABC-transporter, N-terminal domain 87 - 136 IPR029481
domain ATP-binding cassette transporter, PDR-like subfamily G, domain 2 805 - 1035 IPR034003
domain ABC transporter family G domain 372 - 427 IPR043926-1
domain ABC transporter family G domain 1009 - 1073 IPR043926-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

7 GO annotations of biological process

Name Definition
abscisic acid transport The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore.
abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
carbohydrate export The directed movement of carbohydrates out of a cell or organelle.
import into cell The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
intercellular transport The movement of substances between cells.
negative regulation of post-embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08409 AUS1 ATP-dependent permease AUS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40550 PDR11 ATP-dependent permease PDR11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8GU92 ABCG35 ABC transporter G family member 35 Oryza sativa subsp japonica (Rice) PR
Q8GU83 ABCG41 ABC transporter G family member 41 Oryza sativa subsp japonica (Rice) PR
Q9MAG3 ABCG24 ABC transporter G family member 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFH0 ABCG37 ABC transporter G family member 37 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUT8 ABCG33 ABC transporter G family member 33 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZR9 ABCG9 ABC transporter G family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
O81016 ABCG32 ABC transporter G family member 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q7PC81 ABCG43 ABC transporter G family member 43 Arabidopsis thaliana (Mouse-ear cress) PR
Q9MAH4 ABCG10 ABC transporter G family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2V6 ABCG17 ABC transporter G family member 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q7PC82 ABCG42 ABC transporter G family member 42 Arabidopsis thaliana (Mouse-ear cress) PR
Q7PC83 ABCG41 ABC transporter G family member 41 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MIQTGEEDEE KATSLEVEFA SGNGVDDEEE LRLQWATVER LPTFKRVTTA LLARDEVSGK
70 80 90 100 110 120
GRVIDVTRLE GAERRLLIEM LVKQIEDDNL RLLRKIRKRI DKVGIELPTV EVRFNNLSVE
130 140 150 160 170 180
AECQVIHGKP IPTLWNTIKG LLSEFICSKK ETKIGILKGV SGIVRPGRMT LLLGPPGCGK
190 200 210 220 230 240
TTLLQALSGK FSDSVKVGGE VCYNGCSLSE FIPEKTSSYI SQNDLHIPEL SVRETLDFSA
250 260 270 280 290 300
CCQGIGSRME IMKEISRMEK LQEIIPDPAV DAYMKATSVE GLKNNLQTDY ILKILGLDIC
310 320 330 340 350 360
ADTRVGDATR PGISGGEKRR LTTGELVVGP ATTLFMDEIS NGLDSSTTFQ IVSCLQQLAH
370 380 390 400 410 420
IAEATILISL LQPAPETFEL FDDVILMGEG KIIYHAPRAD ICRFFEEFGF KCPERKGVAD
430 440 450 460 470 480
FLQEIMSKKD QEQYWCHRDK PYSYISVDSF INKFKESNLG LLLKEELSKP FNKSQTRKDG
490 500 510 520 530 540
LCYKKYSLGK WEMLKACSRR EFLLMKRNSF IYLFKSALLV FNALVTMTVF LQVGATTDSL
550 560 570 580 590 600
HGNYLMGSLF TALFRLLADG LPELTLTISR LGVFCKQKDL YFYPAWAYAI PSIILKIPLS
610 620 630 640 650 660
VLDSFIWTLL TYYVIGYSPE VKRFFLQFLI LSTFNLSCVS MFRAIAAIFR TIIASTITGA
670 680 690 700 710 720
ISILVLSLFG GFVIPKSSMP AWLGWGFWLS PLSYAEIGLT ANEFFSPRWS KVISSKTTAG
730 740 750 760 770 780
EQMLDIRGLN FGRHSYWTAF GALVGFVLFF NALYVLALTY QNNPQRSRAI ISHEKYSRPI
790 800 810 820 830 840
EEDFKPCPKI TSRAKTGKII LPFKPLTVTF QNVQYYIETP QGKTRQLLSD ITGALKPGVL
850 860 870 880 890 900
TSLMGVSGAG KTTLLDVLSG RKTRGIIKGE IKVGGYPKVQ ETFARVSGYC EQFDIHSPNI
910 920 930 940 950 960
TVEESLKYSA WLRLPYNIDS KTKNELVKEV LETVELDDIK DSVVGLPGIS GLSIEQRKRL
970 980 990 1000 1010 1020
TIAVELVANP SIIFMDEPTT GLDARAAAIV MRAVKNVAET GRTVVCTIHQ PSIDIFETFD
1030 1040 1050 1060 1070 1080
ELILMKNGGQ LVYYGPPGQN SSKVIEYFES FSGLPKIQKN CNPATWILDI TSKSAEEKLG
1090 1100 1110 1120 1130 1140
IDFSQSYKDS TLYKQNKMVV EQLSSASLGS EALRFPSQFS QTAWVQLKAC LWKQHYSYWR
1150 1160 1170 1180 1190 1200
NPSHNITRIV FILLDSTLCG LLFWQKAEDI NNQQDLISIF GSMYTLVVFP GMNNCAAVIN
1210 1220 1230 1240 1250 1260
FIAAERNVFY RERFARMYSS WAYSFSQVLI EVPYSLLQSL LCTIIVYPTI GYHMSVYKMF
1270 1280 1290 1300 1310 1320
WSLYSIFCSL LIFNYSGMLM VALTPNIHMA VTLRSSFFSM LNLFAGFVIP KQKIPKWWIW
1330 1340 1350 1360 1370 1380
MYYLSPTSWV LEGLLSSQYG DVDKEILVFG EKKRVSAFLE DYFGYKHESL AVVAFVLIAY
1390
PIIVATLFAF FMSKLSFQKK