Q08409
PR
Gene name |
AUS1 (YOR011W) |
Protein name |
ATP-dependent permease AUS1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR011W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08409
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08409-F1 | Predicted | AlphaFoldDB |
21 variants for Q08409
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-349766 | 30 | G>C | No | SGRP | |
| s15-349987 | 103 | E>D | No | SGRP | |
| s15-350032 | 118 | H>Q | No | SGRP | |
| s15-350377 | 233 | S>R | No | SGRP | |
| s15-350618 | 314 | V>I | No | SGRP | |
| s15-350696 | 340 | Q>E | No | SGRP | |
| s15-350995 | 439 | M>I | No | SGRP | |
| s15-351333 | 552 | K>R | No | SGRP | |
| s15-351470 | 598 | N>D | No | SGRP | |
| s15-351780 | 701 | V>A | No | SGRP | |
| s15-351845 | 723 | I>V | No | SGRP | |
| s15-352665 | 996 | N>S | No | SGRP | |
| s15-352707 | 1010 | L>R | No | SGRP | |
| s15-352710 | 1011 | T>I | No | SGRP | |
| s15-352775 | 1033 | K>E | No | SGRP | |
| s15-352946 | 1090 | G>S | No | SGRP | |
| s15-353226 | 1183 | S>C | No | SGRP | |
| s15-353702 | 1342 | V>I | No | SGRP | |
| s15-353798 | 1374 | P>S | No | SGRP | |
| s15-353825 | 1383 | V>I | No | SGRP | |
| s15-353840 | 1388 | G>R | No | SGRP |
No associated diseases with Q08409
10 regional properties for Q08409
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 33 - 273 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 751 - 978 | IPR003439-2 |
| domain | AAA+ ATPase domain | 774 - 955 | IPR003593 |
| domain | CDR ABC transporter | 591 - 669 | IPR010929 |
| domain | ABC-2 type transporter, transmembrane domain | 370 - 579 | IPR013525-1 |
| domain | ABC-2 type transporter, transmembrane domain | 1062 - 1273 | IPR013525-2 |
| conserved_site | ABC transporter-like, conserved site | 172 - 186 | IPR017871 |
| domain | ATP-binding cassette transporter, PDR-like subfamily G, domain 1 | 49 - 255 | IPR034001 |
| domain | ATP-binding cassette transporter, PDR-like subfamily G, domain 2 | 748 - 961 | IPR034003 |
| domain | ABC transporter family G domain | 935 - 1000 | IPR043926 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type sterol transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| sterol import | The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40550 | PDR11 | ATP-dependent permease PDR11 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8GU92 | ABCG35 | ABC transporter G family member 35 | Oryza sativa subsp japonica (Rice) | PR |
| Q8GU83 | ABCG41 | ABC transporter G family member 41 | Oryza sativa subsp japonica (Rice) | PR |
| O81016 | ABCG32 | ABC transporter G family member 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7PC83 | ABCG41 | ABC transporter G family member 41 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFH0 | ABCG37 | ABC transporter G family member 37 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZUT8 | ABCG33 | ABC transporter G family member 33 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7PC81 | ABCG43 | ABC transporter G family member 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7PC82 | ABCG42 | ABC transporter G family member 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GZ52 | ABCG30 | ABC transporter G family member 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISKYFTPV | ADGSLTFNGA | NIQFGADAQG | ESKKSYDAED | SMPNPANQLN | DITFQAEAGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MVLVLGYPTS | TLFKTLFHGK | TSLSYSPPGS | IKFKNNEFKS | FSEKCPHQII | YNNEQDVHFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLTVEQTIDF | ALSCKFDIPK | GERDQIRNEL | LREFGLSHVL | KTIVGNDFFR | GVSGGERKRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIIETFIANG | SVYLWDNSTK | GLDSATALDF | LEILRKMAKA | TRSVNLVRIS | QASDKIVDKF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKILMLSDSY | QLFYGTVDEC | LTYFRDTLGI | EKDPNDCIIE | YLTSILNFQF | KNKNLGNLSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSSASVLKTA | TGEVTKYTYN | SDFDLYDQWK | HSSYYRNIKQ | QIQGSSIDDS | IKEVDPSDVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PIFNIPLKKQ | LLFCTKRAFQ | RSLGDKAYMT | AQFISVVIQS | LVIGSLFYEI | PLTTIGSYSR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSLTFFSILF | FTFLSLADMP | IAFQRQPVVK | KQSQLHFYTN | WVETLSTTVF | DYCFKLCLVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VFSIILYFLA | HLQYKAARFF | IFLLFLSFYN | FCMVSLFALT | TLVAPTISVA | NLFAGILLLA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IAMYASYVIY | LKNMHPWFVW | IAYLNPAMYA | MEAILSNELY | NLKLDCSETI | VPRGPTYNDV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFSHKACAWQ | GATLGNDYVR | GRDYLKQGLS | YTYHHVWRNF | GIIIGFLVFF | IACTLFASQY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IKPYFNKDEI | ERNNSRLTRW | LPFLNKKRGT | RSSARNDSKY | VGIPKSHSVS | SSSSSLSAVP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YQISPSNKEM | ALNDYNEQPI | TETVETQKHI | ISWKNINYTV | GTKKLINNAS | GFISSGLTAL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MGESGAGKTT | LLNVLSQRVE | TGVVSGEILI | DGHPLTDEDA | FKRSIGFVQQ | QDLHLDLLSV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KESLEISCLL | RGDGDRAYLD | TVSNLLKLPS | DILVADLNPT | QRKLLSIGVE | LVTKPSLLLF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LDEPTSGLDA | EAALTIVKFL | KQLSLQGQAI | FCTIHQPSKS | VISHFDNIFL | LKRGGECVFF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GPMDDACGYF | MSHDNTLVYD | KEHDNPADFV | IDAVGNSNSS | AGKDTAEEAL | TLNKEAIDWS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ALWESSVEKK | LVKKETARLE | DDARASGVDY | TTSLWKQPSY | LQQLALITRR | QYICTKRDMT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| YVMAKYCLNG | GAGLFIGFSF | WHIKHNIIGL | QDSIFFCFMA | LCVSSPLINQ | IQDKALKTKE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VYVAREARSN | TYHWTVLLLS | QSIIELPLAL | TSSTLFFVCA | FFSCGFNNAG | WSAGVFFLNY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| MLFAAYYSTL | GLWLIYTAPN | LQTAAVFVAF | IYSFTASFCG | VMQPYSLFPT | FWKFMYRVSP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| YTYFVETFVS | ILLHNWEIKC | DMSEMVPGQP | LTGQSCGQFM | EAFIEEYGGY | LHNKNTFTVC |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| AYCTYTVGDD | FLKNENMSYD | HVWRNFGIEW | AFVGFNFFAM | FAGYYLTYVA | RIWPKVFKII |
| 1390 | |||||
| TKVIPHRGKK | PVQN |