Q5BK10
Gene name |
Capn13 |
Protein name |
Calpain-13 |
Names |
Calcium-activated neutral proteinase 13, CANP 13 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:362701 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5BK10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5BK10-F1 | Predicted | AlphaFoldDB |
1 variants for Q5BK10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs197578247 | 663 | K>N | No | EVA |
No associated diseases with Q5BK10
No regional properties for Q5BK10
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5BK10 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27970 | CAPN1 | Calpain-1 catalytic subunit | Bos taurus (Bovine) | PR |
| Q27971 | CAPN2 | Calpain-2 catalytic subunit | Bos taurus (Bovine) | PR |
| P00789 | Calpain-1 catalytic subunit | Gallus gallus (Chicken) | PR | |
| Q9VXH6 | CalpC | Calpain-C | Drosophila melanogaster (Fruit fly) | PR |
| Q9UBV8 | PEF1 | Peflin | Homo sapiens (Human) | PR |
| P28676 | GCA | Grancalcin | Homo sapiens (Human) | PR |
| O14815 | CAPN9 | Calpain-9 | Homo sapiens (Human) | PR |
| Q9HC96 | CAPN10 | Calpain-10 | Homo sapiens (Human) | PR |
| P07384 | CAPN1 | Calpain-1 catalytic subunit | Homo sapiens (Human) | PR |
| Q6MZZ7 | CAPN13 | Calpain-13 | Homo sapiens (Human) | PR |
| Q8BFY6 | Pef1 | Peflin | Mus musculus (Mouse) | PR |
| O35350 | Capn1 | Calpain-1 catalytic subunit | Mus musculus (Mouse) | PR |
| Q9ESK3 | Capn10 | Calpain-10 | Mus musculus (Mouse) | PR |
| G3UZ78 | Adgb | Androglobin | Mus musculus (Mouse) | PR |
| O08529 | Capn2 | Calpain-2 catalytic subunit | Mus musculus (Mouse) | PR |
| Q9D805 | Capn9 | Calpain-9 | Mus musculus (Mouse) | PR |
| Q3UW68 | Capn13 | Calpain-13 | Mus musculus (Mouse) | PR |
| P35750 | CAPN1 | Calpain-1 catalytic subunit | Sus scrofa (Pig) | PR |
| P43367 | CAPN2 | Calpain-2 catalytic subunit | Sus scrofa (Pig) | PR |
| Q641Z8 | Pef1 | Peflin | Rattus norvegicus (Rat) | PR |
| O35920 | Capn9 | Calpain-9 | Rattus norvegicus (Rat) | PR |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | Rattus norvegicus (Rat) | PR |
| P97571 | Capn1 | Calpain-1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHDTEALEE | TSVVKFKNQD | FRFLRDRCLS | RGQLFIDDTF | PAEASSIGQK | LLMGKRLPKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EWKRPQDLSF | GPPHFILEGA | SRFDIQQGRA | GDCWFLAALG | SLTQNPQCLQ | KILMNQSFSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QYAGIFHFRF | WQCGQWVEVV | IDDRLPVVGN | NFCFVHPRRG | NQEFWPCLME | KAYAKLLGSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQLHYGYLPD | ALVDLTGGVV | TRINLHSSPS | DLLMVVKTAV | QTGSMVACAT | PKWLTEESEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MENGLVSQHA | YTVTGAEKIQ | YRRGWEEIIR | LWNPWGNTEW | RGRWGDGSQE | WWETHGSRKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLYENKDDGE | FWMSCRDFHE | NFSCLYICSQ | FPITMDPGVT | PNESWRQMRF | KNQVISGNTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGDGRDIQYL | FDVQEPMDGN | NVIVAFTVMP | QSLKTEEWPF | PLQFQVFKVD | SQFQKFQKRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPAFFSQFRD | AAQGIDYVTK | RNFTKSFHLS | PGTYVVVASA | HGKEVEFLLR | IFLKMPHKDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPNSSFNLKA | LKGSLSENES | PKSSFHRYMD | QGLDIDASQL | QSLLNQEYLT | GPPGDTFSLD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QCQSIMALMD | LKVNGRLDRE | EFARLQSRLI | HCQHVFQHIQ | RSQGVLRSSD | LWEVIESTDF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSGVLLSKEL | LSLMTLRYSD | SSGRLSFPSL | VCFLIRLETM | SKAFRNLSKD | GKSIYLTEME |
| WMKLVMYS |