Q27971
PR
Gene name |
CAPN2 |
Protein name |
Calpain-2 catalytic subunit |
Names |
Calcium-activated neutral proteinase 2, CANP 2, Calpain M-type, Calpain-2 large subunit, Millimolar-calpain, M-calpain |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281662 |
EC number |
3.4.22.53: Cysteine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q27971
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q27971-F1 | Predicted | AlphaFoldDB |
162 variants for Q27971
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs438188014 | 37 | D>N | No | EVA | |
| rs799877241 | 50 | S>P | No | EVA | |
| rs471724620 | 60 | F>L | No | EVA | |
| rs456678634 | 60 | F>Y | No | EVA | |
| rs438833348 | 61 | K>M | No | EVA | |
| rs454007432 | 61 | K>N | No | EVA | |
| rs466283267 | 129 | Q>K | No | EVA | |
| rs473558906 | 174 | S>R | No | EVA | |
| rs442251221 | 175 | E>G | No | EVA | |
| rs462394677 | 180 | L>R | No | EVA | |
| rs451799077 | 193 | E>G | No | EVA | |
| rs452839945 | 218 | R>M | No | EVA | |
| rs434227767 | 227 | I>V | No | EVA | |
| rs454300304 | 235 | G>V | No | EVA | |
| rs453511840 | 244 | I>L | No | EVA | |
| rs473618232 | 244 | I>S | No | EVA | |
| rs462438087 | 247 | A>T | No | EVA | |
| rs463231243 | 251 | E>D | No | EVA | |
| rs476892371 | 252 | A>V | No | EVA | |
| rs445735597 | 257 | K>N | No | EVA | |
| rs459356541 | 258 | L>P | No | EVA | |
| rs448330554 | 259 | V>G | No | EVA | |
| rs479674980 | 259 | V>M | No | EVA | |
| rs468450679 | 260 | K>Q | No | EVA | |
| rs437136069 | 261 | G>R | No | EVA | |
| rs450789906 | 263 | A>S | No | EVA | |
| rs433232817 | 268 | G>C | No | EVA | |
| rs433713658 | 276 | G>A | No | EVA | |
| rs433713658 | 276 | G>V | No | EVA | |
| rs453879454 | 278 | L>P | No | EVA | |
| rs467573505 | 280 | K>N | No | EVA | |
| rs456293422 | 284 | I>M | No | EVA | |
| rs436266757 | 284 | I>T | No | EVA | |
| rs476371987 | 291 | V>G | No | EVA | |
| rs438760896 | 292 | E>D | No | EVA | |
| rs452436536 | 297 | W>G | No | EVA | |
| rs472728806 | 298 | N>K | No | EVA | |
| rs441324090 | 299 | D>E | No | EVA | |
| rs461532907 | 300 | N>Y | No | EVA | |
| rs463357664 | 308 | D>G | No | EVA | |
| rs477023022 | 325 | W>* | No | EVA | |
| rs469132432 | 326 | M>L | No | EVA | |
| rs437802170 | 327 | S>A | No | EVA | |
| rs451442730 | 327 | S>F | No | EVA | |
| rs451307321 | 328 | F>C | No | EVA | |
| rs471700242 | 328 | F>L | No | EVA | |
| rs440323247 | 329 | N>T | No | EVA | |
| rs474223720 | 334 | H>D | No | EVA | |
| rs442837360 | 334 | H>Q | No | EVA | |
| rs462889628 | 335 | Y>H | No | EVA | |
| rs482971543 | 337 | R>L | No | EVA | |
| rs459111666 | 342 | N>D | No | EVA | |
| rs479339445 | 344 | T>P | No | EVA | |
| rs466553005 | 346 | D>Y | No | EVA | |
| rs480223658 | 347 | T>P | No | EVA | |
| rs448956642 | 349 | T>P | No | EVA | |
| rs469069206 | 350 | S>I | No | EVA | |
| rs437738695 | 350 | S>R | No | EVA | |
| rs451466677 | 351 | D>E | No | EVA | |
| rs465145230 | 355 | K>T | No | EVA | |
| rs433833399 | 356 | W>G | No | EVA | |
| rs453948599 | 357 | K>* | No | EVA | |
| rs473954835 | 358 | L>I | No | EVA | |
| rs442772389 | 358 | L>P | No | EVA | |
| rs456412746 | 359 | T>P | No | EVA | |
| rs438892604 | 362 | D>G | No | EVA | |
| rs459120901 | 369 | S>T | No | EVA | |
| rs479268548 | 371 | A>P | No | EVA | |
| rs481764058 | 374 | C>G | No | EVA | |
| rs448893221 | 376 | N>S | No | EVA | |
| rs436754877 | 379 | N>I | No | EVA | |
| rs456917425 | 394 | E>A | No | EVA | |
| rs470690228 | 396 | E>Q | No | EVA | |
| rs432904720 | 397 | D>N | No | EVA | |
| rs453053025 | 397 | D>V | No | EVA | |
| rs473207240 | 398 | Q>* | No | EVA | |
| rs441897370 | 399 | E>Q | No | EVA | |
| rs444414799 | 406 | T>P | No | EVA | |
| rs458104522 | 416 | R>L | No | EVA | |
| rs460544862 | 426 | M>I | No | EVA | |
| rs480631261 | 428 | T>P | No | EVA | |
| rs449440761 | 429 | I>L | No | EVA | |
| rs462340398 | 430 | G>S | No | EVA | |
| rs450441226 | 432 | G>R | No | EVA | |
| rs464141800 | 434 | Y>F | No | EVA | |
| rs432831279 | 435 | E>* | No | EVA | |
| rs437442933 | 448 | L>I | No | EVA | |
| rs457643218 | 452 | F>V | No | EVA | |
| rs471315913 | 456 | T>I | No | EVA | |
| rs431940563 | 458 | A>E | No | EVA | |
| rs460167575 | 458 | A>S | No | EVA | |
| rs440892508 | 460 | E>Q | No | EVA | |
| rs443451736 | 465 | F>V | No | EVA | |
| rs463664055 | 466 | I>L | No | EVA | |
| rs477387946 | 471 | V>G | No | EVA | |
| rs446048132 | 475 | F>C | No | EVA | |
| rs446048132 | 475 | F>S | No | EVA | |
| rs459760357 | 477 | L>P | No | EVA | |
| rs448608079 | 478 | P>S | No | EVA | |
| rs468723591 | 480 | G>R | No | EVA | |
| rs437385228 | 481 | E>* | No | EVA | |
| rs110231713 | 481 | E>A | No | EVA | |
| rs110231713 | 481 | E>G | No | EVA | |
| rs110231713 | 481 | E>V | No | EVA | |
| rs433497213 | 483 | I>N | No | EVA | |
| rs451965557 | 484 | V>L | No | EVA | |
| rs472021707 | 485 | V>G | No | EVA | |
| rs454482498 | 487 | S>P | No | EVA | |
| rs474757494 | 488 | T>P | No | EVA | |
| rs443405620 | 490 | E>G | No | EVA | |
| rs463555165 | 492 | N>H | No | EVA | |
| rs470888265 | 492 | N>T | No | EVA | |
| rs439546564 | 494 | D>G | No | EVA | |
| rs479812317 | 496 | D>A | No | EVA | |
| rs459698931 | 496 | D>Y | No | EVA | |
| rs448543094 | 497 | F>L | No | EVA | |
| rs462242120 | 498 | C>G | No | EVA | |
| rs518013737 | 500 | R>W | No | EVA | |
| rs464744722 | 501 | V>D | No | EVA | |
| rs464744722 | 501 | V>G | No | EVA | |
| rs447114990 | 502 | F>I | No | EVA | |
| rs434344467 | 504 | E>Q | No | EVA | |
| rs454418855 | 506 | K>N | No | EVA | |
| rs436908619 | 507 | A>D | No | EVA | |
| rs468280364 | 507 | A>P | No | EVA | |
| rs470780704 | 508 | D>A | No | EVA | |
| rs470780704 | 508 | D>G | No | EVA | |
| rs457088093 | 508 | D>Y | No | EVA | |
| rs453223525 | 509 | Y>F | No | EVA | |
| rs482476470 | 527 | E>D | No | EVA | |
| rs451037750 | 528 | D>G | No | EVA | |
| rs464677898 | 531 | D>G | No | EVA | |
| rs478341138 | 533 | G>R | No | EVA | |
| rs445578123 | 538 | F>L | No | EVA | |
| rs467279106 | 542 | A>V | No | EVA | |
| rs460707230 | 567 | I>M | No | EVA | |
| rs472783905 | 582 | D>E | No | EVA | |
| rs208365307 | 586 | S>L | No | EVA | |
| rs474771436 | 614 | I>N | No | EVA | |
| rs434606123 | 635 | G>A | No | EVA | |
| rs454817672 | 636 | F>S | No | EVA | |
| rs468496617 | 637 | K>E | No | EVA | |
| rs437177606 | 637 | K>N | No | EVA | |
| rs457347153 | 638 | M>L | No | EVA | |
| rs453380880 | 669 | L>R | No | EVA | |
| rs473402616 | 670 | E>K | No | EVA | |
| rs442205662 | 671 | T>K | No | EVA | |
| rs442205662 | 671 | T>R | No | EVA | |
| rs442143196 | 688 | Q>K | No | EVA | |
| rs483123357 | 694 | W>C | No | EVA | |
| rs442749682 | 694 | W>G | No | EVA | |
| rs462911093 | 694 | W>L | No | EVA | |
| rs465504562 | 695 | L>R | No | EVA | |
| rs134883148 | 696 | S>A | No | EVA | |
| rs135592390 | 696 | S>C | No | EVA | |
| rs135592390 | 696 | S>F | No | EVA | |
| rs468042895 | 698 | S>A | No | EVA | |
| rs136785487 | 698 | S>L | No | EVA | |
| rs436692595 | 699 | V>L | No | EVA | |
| rs455285007 | 700 | L>F | No | EVA | |
| rs468943907 | 701 | L>C | No | EVA | |
| rs468943907 | 701 | L>W | No | EVA |
No associated diseases with Q27971
8 regional properties for Q27971
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 99 - 110 | IPR000169 |
| domain | Peptidase C2, calpain, catalytic domain | 27 - 352 | IPR001300 |
| domain | EF-hand domain | 602 - 637 | IPR002048 |
| binding_site | EF-Hand 1, calcium-binding site | 615 - 627 | IPR018247 |
| domain | Peptidase C2, calpain, large subunit, domain III | 362 - 502 | IPR022682 |
| domain | Peptidase C2, calpain, domain III | 355 - 510 | IPR022683 |
| domain | Calpain subdomain III | 354 - 510 | IPR033883 |
| domain | CAPN2, penta-EF hand, calcium binding motif | 533 - 700 | IPR042736 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.22.53 | Cysteine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| regulation of cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27970 | CAPN1 | Calpain-1 catalytic subunit | Bos taurus (Bovine) | PR |
| P00789 | Calpain-1 catalytic subunit | Gallus gallus (Chicken) | PR | |
| Q9VXH6 | CalpC | Calpain-C | Drosophila melanogaster (Fruit fly) | PR |
| O14815 | CAPN9 | Calpain-9 | Homo sapiens (Human) | PR |
| Q6MZZ7 | CAPN13 | Calpain-13 | Homo sapiens (Human) | PR |
| Q9HC96 | CAPN10 | Calpain-10 | Homo sapiens (Human) | PR |
| P07384 | CAPN1 | Calpain-1 catalytic subunit | Homo sapiens (Human) | PR |
| O35350 | Capn1 | Calpain-1 catalytic subunit | Mus musculus (Mouse) | PR |
| Q9ESK3 | Capn10 | Calpain-10 | Mus musculus (Mouse) | PR |
| G3UZ78 | Adgb | Androglobin | Mus musculus (Mouse) | PR |
| Q9D805 | Capn9 | Calpain-9 | Mus musculus (Mouse) | PR |
| Q3UW68 | Capn13 | Calpain-13 | Mus musculus (Mouse) | PR |
| O08529 | Capn2 | Calpain-2 catalytic subunit | Mus musculus (Mouse) | PR |
| P35750 | CAPN1 | Calpain-1 catalytic subunit | Sus scrofa (Pig) | PR |
| P43367 | CAPN2 | Calpain-2 catalytic subunit | Sus scrofa (Pig) | PR |
| O35920 | Capn9 | Calpain-9 | Rattus norvegicus (Rat) | PR |
| P97571 | Capn1 | Calpain-1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| Q5BK10 | Capn13 | Calpain-13 | Rattus norvegicus (Rat) | PR |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGIAAKLAK | DREAAEGLGS | HERAVKYLNQ | DYAALRDECL | EAGALFQDPS | FPALPSSLGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELGPYSSKT | RGIEWKRPTE | ICDNPQFITG | GATRTDICQG | ALGDCWLLAA | IASLTLNEEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LARVVPLDQS | FQENYAGIFH | FQFWQYGEWV | EVVVDDRLPT | KDGELLFVHS | AEGSEFWSAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEKAYAKING | CYEALSGGAT | TEGFEDFTGG | IAEWYELRKA | PPNLFRIIQK | ALQKGSLLGC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SIDITSAADS | EAITFQKLVK | GHAYSVTGAE | EVESRGSLQK | LIRIRNPWGE | VEWTGQWNDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CPNWNTVDPE | VRETLTRQHE | DGEFWMSFND | FLRHYSRLEI | CNLTPDTLTS | DSYKKWKLTK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MDGNWRRGST | AGGCRNYPNT | FWMNPQYLIK | LEEEDEDQED | GESGCTFLVG | LIQKHRRRQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KMGEDMHTIG | FGIYEVPEEL | TGQTNIHLSK | KFFLTTRARE | RSDTFINLRE | VLNRFKLPPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EYIVVPSTFE | PNKDGDFCIR | VFSEKKADYQ | VVDDEIEANI | DEIDISEDDI | DDGFRRLFAQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LAGEDAEISA | FELQTILRRV | LAKRQDIKSD | GFSIETCKIM | VDMLDSDGSG | KLGLKEFYIL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WTKIQKYQKI | YREIDVDRSG | TMNSYEMRKA | LEEAGFKMPC | QLHQVIVARF | ADDDLIIDFD |
| 670 | 680 | 690 | |||
| NFVRCLIRLE | TLFRIFKQLD | PENTGMIQLD | LISWLSFSVL |