Q9ESK3
PR
Gene name |
Capn10 (Capn8) |
Protein name |
Calpain-10 |
Names |
Calcium-activated neutral proteinase 10, CANP 10 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:23830 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ESK3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ESK3-F1 | Predicted | AlphaFoldDB |
40 variants for Q9ESK3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8276988 | 6 | A>V | No | EVA | |
| rs214830573 | 10 | A>G | No | EVA | |
| rs3388489836 | 50 | C>Y | No | EVA | |
| rs3388490654 | 84 | K>N | No | EVA | |
| rs3388488619 | 97 | Q>H | No | EVA | |
| rs3388489549 | 114 | W>* | No | EVA | |
| rs3388490764 | 134 | R>* | No | EVA | |
| rs3388489440 | 137 | F>L | No | EVA | |
| rs3388487830 | 201 | S>N | No | EVA | |
| rs3388488376 | 207 | T>N | No | EVA | |
| rs3388491112 | 212 | L>V | No | EVA | |
| rs3388489769 | 215 | K>M | No | EVA | |
| rs3388487835 | 220 | I>F | No | EVA | |
| rs3390297959 | 232 | R>M | No | EVA | |
| rs8277066 | 251 | Q>R | No | EVA | |
| rs3390249604 | 274 | W>* | No | EVA | |
| rs3388488641 | 299 | G>E | No | EVA | |
| rs3388488608 | 314 | E>G | No | EVA | |
| rs3388487824 | 334 | R>G | No | EVA | |
| rs3388487554 | 344 | G>S | No | EVA | |
| rs3388487855 | 347 | V>E | No | EVA | |
| rs3388491305 | 359 | S>I | No | EVA | |
| rs217054125 | 388 | R>L | No | EVA | |
| rs3388488167 | 395 | A>T | No | EVA | |
| rs3388489713 | 405 | N>S | No | EVA | |
| rs3388489502 | 462 | A>V | No | EVA | |
| rs3388491123 | 470 | D>G | No | EVA | |
| rs3388490822 | 474 | Q>* | No | EVA | |
| rs3388488073 | 480 | F>Y | No | EVA | |
| rs3388490723 | 504 | P>H | No | EVA | |
| rs3388490683 | 512 | Q>* | No | EVA | |
| rs3388488158 | 513 | L>M | No | EVA | |
| rs3388488440 | 529 | F>Y | No | EVA | |
| rs3388491227 | 534 | C>S | No | EVA | |
| rs3388490805 | 576 | V>D | No | EVA | |
| rs3388488810 | 582 | N>I | No | EVA | |
| rs30395437 | 585 | A>E | No | EVA | |
| rs8277025 | 601 | R>C | No | EVA | |
| rs864265735 | 627 | D>V | No | EVA | |
| rs3413086952 | 666 | A>S | No | EVA |
No associated diseases with Q9ESK3
8 regional properties for Q9ESK3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 67 - 78 | IPR000169 |
| domain | Peptidase C2, calpain, catalytic domain | 2 - 329 | IPR001300 |
| domain | Peptidase C2, calpain, large subunit, domain III | 344 - 480 | IPR022682-1 |
| domain | Peptidase C2, calpain, large subunit, domain III | 514 - 636 | IPR022682-2 |
| domain | Peptidase C2, calpain, domain III | 338 - 488 | IPR022683-1 |
| domain | Peptidase C2, calpain, domain III | 507 - 645 | IPR022683-2 |
| domain | Calpain subdomain III | 337 - 490 | IPR033883-1 |
| domain | Calpain subdomain III | 506 - 647 | IPR033883-2 |
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of glucose import | Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
| positive regulation of insulin secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. |
| positive regulation of intracellular transport | Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. |
| positive regulation of type B pancreatic cell apoptotic process | Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| response to nutrient levels | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. |
| type B pancreatic cell apoptotic process | Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27970 | CAPN1 | Calpain-1 catalytic subunit | Bos taurus (Bovine) | PR |
| Q27971 | CAPN2 | Calpain-2 catalytic subunit | Bos taurus (Bovine) | PR |
| P00789 | Calpain-1 catalytic subunit | Gallus gallus (Chicken) | PR | |
| Q9VXH6 | CalpC | Calpain-C | Drosophila melanogaster (Fruit fly) | PR |
| O14815 | CAPN9 | Calpain-9 | Homo sapiens (Human) | PR |
| Q6MZZ7 | CAPN13 | Calpain-13 | Homo sapiens (Human) | PR |
| P07384 | CAPN1 | Calpain-1 catalytic subunit | Homo sapiens (Human) | PR |
| Q9HC96 | CAPN10 | Calpain-10 | Homo sapiens (Human) | PR |
| G3UZ78 | Adgb | Androglobin | Mus musculus (Mouse) | PR |
| O08529 | Capn2 | Calpain-2 catalytic subunit | Mus musculus (Mouse) | PR |
| O35350 | Capn1 | Calpain-1 catalytic subunit | Mus musculus (Mouse) | PR |
| Q3UW68 | Capn13 | Calpain-13 | Mus musculus (Mouse) | PR |
| Q9D805 | Capn9 | Calpain-9 | Mus musculus (Mouse) | PR |
| P35750 | CAPN1 | Calpain-1 catalytic subunit | Sus scrofa (Pig) | PR |
| P43367 | CAPN2 | Calpain-2 catalytic subunit | Sus scrofa (Pig) | PR |
| O35920 | Capn9 | Calpain-9 | Rattus norvegicus (Rat) | PR |
| P97571 | Capn1 | Calpain-1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| Q5BK10 | Capn13 | Calpain-13 | Rattus norvegicus (Rat) | PR |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRAVRAETPA | RELFRDAAFP | ASDSSLFYNL | STPLAQFRED | ITWRRPQEIC | ATPQLFPDNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WEGQVKQGLL | GDCWFLCACA | ALQKSQHLLD | QVFPPGQPGW | SDQKYQGFFT | CRIWQFGHWE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVTIDDRLPC | LAGRLCFSRC | QREDVFWLPL | LEKAYAKVHG | SYEHLWAGQV | ADALVDLTGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAERWSLKDV | TKASGQQDRP | SGGEHRTCRQ | LLHLKDRCLI | SCSVLSPRAG | ARELGEFHAF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IISDLQELRS | QTGQGILLLR | IHNPWGRRCW | QGLWREGGEG | WNQVEPAKES | ELLAQLQEGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FWVEEEEFLR | EFDEVTIGYP | VTEAGHLQSL | HTERVLCHTR | TLPGAWVTGQ | SAGGCRNNSC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPCNPKFWLR | LLEPSEVCVA | VLQRPRRRLV | GQTRALAGAS | PAPVNLPGKD | YQAVGLHIWK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VEKRKISLPR | VLSAPPVAGT | ACHAYDREIH | LRCELSPGYY | LAVPSTFLKD | VPGQFLLRVF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| STGKISLSAV | RLATKGASPG | TALPAGEWET | VQLQGCWRAG | QTAGGSRNFA | SYPCNPCLPF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVPEGAGPRY | IRITLQQHCR | LSDSQLHPIG | FHVFQVPADG | ENQDACSLLL | QEPLLSCVPH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RYAQEVSRLC | LLSVGNYRIV | PSTYLPDTEG | TFTVTIATRI | DRQSIHSQEM | LGQLLQEVSF |
| MAVMKA |