Q3UW68

PR
Gene name
Capn13 (Gm943)
Protein name
Calpain-13
Names
Calcium-activated neutral proteinase 13, CANP 13
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:381122
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3UW68

Entry ID Method Resolution Chain Position Source
AF-Q3UW68-F1 Predicted AlphaFoldDB

49 variants for Q3UW68

Variant ID(s) Position Change Description Diseaes Association Provenance
rs107699019 39 A>V No EVA
rs3389474052 81 F>L No EVA
rs3389495972 81 F>L No EVA
rs1132139320 82 D>E No EVA
rs1132741581 82 D>N No EVA
rs1135268124 86 G>* No EVA
rs3389491752 95 A>V No EVA
rs3389486490 112 M>K No EVA
rs3389480023 116 Y>* No EVA
rs3408301547 120 Y>H No EVA
rs3407606959 121 A>T No EVA
rs248131918 145 V>A No EVA
rs3389482771 184 G>C No EVA
rs3389446875 194 T>R No EVA
rs244283977 237 K>R No EVA
rs221104641 259 Y>C No EVA
rs3389479632 289 W>L No EVA
rs3389482748 313 C>* No EVA
rs222078118 318 E>D No EVA
rs3389479993 322 C>Y No EVA
rs3389491698 335 H>L No EVA
rs3389479569 340 N>K No EVA
rs252156739 356 N>I No EVA
rs3389482775 359 G>E No EVA
rs237068187 368 V>L No EVA
rs3389458872 382 V>M No EVA
rs3389446880 388 P>S No EVA
rs224992740 395 E>D No EVA
rs3389427955 402 F>Y No EVA
rs248916881 408 P>A No EVA
rs248916881 408 P>S No EVA
rs3389458918 421 F>I No EVA
rs3407968079 425 F>L No EVA
rs3407023665 426 R>G No EVA
rs3407797589 433 K>* No EVA
rs3407873290 433 K>N No EVA
rs3406122006 452 V>A No EVA
rs3389491730 457 A>V No EVA
rs3407606068 459 G>V No EVA
rs45635253 476 H>Q No EVA
rs52051597 487 A>T No EVA
rs50411310 498 R>Q No EVA
rs3389437543 514 A>P No EVA
rs259087319 564 S>R No EVA
rs48499001 575 S>N No EVA
rs3389479418 600 G>R No EVA
rs3408116368 606 E>* No EVA
rs3408116375 606 E>A No EVA
rs3389458868 632 I>M No EVA

No associated diseases with Q3UW68

4 regional properties for Q3UW68

Type Name Position InterPro Accession
active_site Cysteine peptidase, cysteine active site 85 - 96 IPR000169
domain Peptidase C2, calpain, catalytic domain 12 - 337 IPR001300
domain EF-hand domain 534 - 569 IPR002048
domain Peptidase C2, calpain, large subunit, domain III 363 - 469 IPR022682

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.

2 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27970 CAPN1 Calpain-1 catalytic subunit Bos taurus (Bovine) PR
Q27971 CAPN2 Calpain-2 catalytic subunit Bos taurus (Bovine) PR
P00789 Calpain-1 catalytic subunit Gallus gallus (Chicken) PR
Q9VXH6 CalpC Calpain-C Drosophila melanogaster (Fruit fly) PR
Q9UBV8 PEF1 Peflin Homo sapiens (Human) PR
P28676 GCA Grancalcin Homo sapiens (Human) PR
O14815 CAPN9 Calpain-9 Homo sapiens (Human) PR
Q9HC96 CAPN10 Calpain-10 Homo sapiens (Human) PR
P07384 CAPN1 Calpain-1 catalytic subunit Homo sapiens (Human) PR
Q6MZZ7 CAPN13 Calpain-13 Homo sapiens (Human) PR
Q8BFY6 Pef1 Peflin Mus musculus (Mouse) PR
G3UZ78 Adgb Androglobin Mus musculus (Mouse) PR
O08529 Capn2 Calpain-2 catalytic subunit Mus musculus (Mouse) PR
O35350 Capn1 Calpain-1 catalytic subunit Mus musculus (Mouse) PR
Q9D805 Capn9 Calpain-9 Mus musculus (Mouse) PR
Q9ESK3 Capn10 Calpain-10 Mus musculus (Mouse) PR
P35750 CAPN1 Calpain-1 catalytic subunit Sus scrofa (Pig) PR
P43367 CAPN2 Calpain-2 catalytic subunit Sus scrofa (Pig) PR
Q641Z8 Pef1 Peflin Rattus norvegicus (Rat) PR
O35920 Capn9 Calpain-9 Rattus norvegicus (Rat) PR
P97571 Capn1 Calpain-1 catalytic subunit Rattus norvegicus (Rat) PR
Q07009 Capn2 Calpain-2 catalytic subunit Rattus norvegicus (Rat) PR
Q5BK10 Capn13 Calpain-13 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAHDAETSVV KFKNQDFRTL RDHCLSRGQL FIDDTFPAAA SSIGEKLLRG KHLSKLEWKR
70 80 90 100 110 120
PTSKDLPFYP PHFILEGASR FDIHQGIAGD CWFLAALGSL TQNPQCLQKI LMDQSYSHQY
130 140 150 160 170 180
AGIFQFRFWQ CGQWVEVVID DQLPVIGDNF LFVHPRGGNK EFWPCLMEKA YAKLLGSYSQ
190 200 210 220 230 240
LHYGYLPDAL VDLTGGVVTI INLHSSPFDL LTTVKTAIQA GSMVACATEN GLTEEAKVME
250 260 270 280 290 300
NGLVSQHAYT VTGAEKIQYQ GRWEDIIRLW NPWGKTEWKG RWKDGSKEWR ETHDPRKSQL
310 320 330 340 350 360
YENKEDGEFW MSCQDFQENF SCLFICNQIP ITMDHGVTPN ESWRQMRFTN QVISRNRAGG
370 380 390 400 410 420
HGRDMQYVFS VQEHTAGNNV VVAFTIMPQS LNTEEERFPL QFQVFKVPQF QNVQGRLPPA
430 440 450 460 470 480
FFSPFRSAAQ GTKYVSKCNF TKSFHLNPGT YVVVTTANGK EVEFLLRIFL KMPDKHRDPS
490 500 510 520 530 540
SNFNLRALKE SLPENGSRNS ISYTYMDQGL DIDATQLQSL LNQEFLTGPP GDTFSLDQCQ
550 560 570 580 590 600
SIMALMDLKV NGRLDQEEFA RLRSRLIHCQ HIFQSIQRRP GVLLSSDLWK VIENTDFLVG
610 620 630 640 650 660
IFISSELLSL MALRYSDSSG RVSFPTLVCF LIRLETMAKA FRNLSKDGKG IYLTETEWMN
LVMYS