O35920
Gene name |
Capn9 (Ncl4) |
Protein name |
Calpain-9 |
Names |
Digestive tract-specific calpain, New calpain 4, nCL-4 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:116694 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35920
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35920-F1 | Predicted | AlphaFoldDB |
1 variants for O35920
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs197148177 | 299 | M>V | No | EVA |
No associated diseases with O35920
1 regional properties for O35920
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UDP-glycosyltransferase family, conserved site | 340 - 383 | IPR035595 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| digestion | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27970 | CAPN1 | Calpain-1 catalytic subunit | Bos taurus (Bovine) | PR |
| Q27971 | CAPN2 | Calpain-2 catalytic subunit | Bos taurus (Bovine) | PR |
| P00789 | Calpain-1 catalytic subunit | Gallus gallus (Chicken) | PR | |
| Q9VXH6 | CalpC | Calpain-C | Drosophila melanogaster (Fruit fly) | PR |
| Q6MZZ7 | CAPN13 | Calpain-13 | Homo sapiens (Human) | PR |
| Q9HC96 | CAPN10 | Calpain-10 | Homo sapiens (Human) | PR |
| P07384 | CAPN1 | Calpain-1 catalytic subunit | Homo sapiens (Human) | PR |
| O14815 | CAPN9 | Calpain-9 | Homo sapiens (Human) | PR |
| O35350 | Capn1 | Calpain-1 catalytic subunit | Mus musculus (Mouse) | PR |
| Q9ESK3 | Capn10 | Calpain-10 | Mus musculus (Mouse) | PR |
| G3UZ78 | Adgb | Androglobin | Mus musculus (Mouse) | PR |
| O08529 | Capn2 | Calpain-2 catalytic subunit | Mus musculus (Mouse) | PR |
| Q3UW68 | Capn13 | Calpain-13 | Mus musculus (Mouse) | PR |
| Q9D805 | Capn9 | Calpain-9 | Mus musculus (Mouse) | PR |
| P35750 | CAPN1 | Calpain-1 catalytic subunit | Sus scrofa (Pig) | PR |
| P43367 | CAPN2 | Calpain-2 catalytic subunit | Sus scrofa (Pig) | PR |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | Rattus norvegicus (Rat) | PR |
| Q5BK10 | Capn13 | Calpain-13 | Rattus norvegicus (Rat) | PR |
| P97571 | Capn1 | Calpain-1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPYLHRSLRP | QPQPVPRDAR | TVHSSGHSFE | QLRQSCLQSG | TLFEDADFPA | SNSSLFYSER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQVPFVWKRP | GEIVENPEFI | LGGATRTDIC | QGELGDCWLL | AAIASLTLNQ | KALARVVPQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGFGSGYAGI | FHFQFWQHSE | WLDVVIDDRL | PTFRDRLVFL | HSADHNEFWS | ALLEKAYAKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NGSYEALKGG | SAIEAMEDFT | GGVAENFQIR | EAPEDFYEIL | EKALRRGSLL | GCSIDTLNAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESEARTPLGL | IKGHAYTVTG | LDQVNFHGQR | IKLIRVRNPW | GQVEWNGPWS | DSSPEWRSMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEEQKRLGHT | ALDDGEFWMA | FEDFKTHFDK | VEICNLTPDA | LEDNTLHKWE | VTIHQGSWVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSTAGGCRNF | LDTFWTNPQI | KLSLTERDEG | QEGCTFLAAL | MQKDRRRLKR | FGANMLTIGY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIYQCPDKDG | HLNRDFFRYH | ASLARSKTFI | NLREVSGRFQ | LPPGDYILIP | STFEPHQEAD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FCLRIFSEKK | AVTQDLDENI | DIDLPELPKP | TPQEEETEEE | RQFRALFRRI | AGEDMEVSAE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELEYVLNAVL | QKKTALKFKR | LSLLSCRNII | SLMDTSGNGK | MEFEEFRVFW | DKLRYWMDLF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQFDVDKSGT | MSSYELRTAL | KAAGFQLGSH | LLQLIVLRYA | DENLQLDFDD | YLNCLVRLEN |
| 670 | 680 | ||||
| ASRVFQCLSV | KNKDFIHLNI | NEFINLTMNI |