G3UZ78

PR
Gene name
Adgb (Capn7l)
Protein name
Androglobin
Names
Calpain-7-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

271-403 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for G3UZ78

Entry ID Method Resolution Chain Position Source
AF-G3UZ78-F1 Predicted AlphaFoldDB

59 variants for G3UZ78

Variant ID(s) Position Change Description Diseaes Association Provenance
rs48080033 28 H>Y No EVA
rs221951183 157 N>S No EVA
rs231682478 166 L>P No EVA
rs214311802 184 V>G No EVA
rs581527254 252 V>I No EVA
rs3400855613 256 H>P No EVA
rs3400848665 256 H>PSQSVDYCEFS* No EVA
rs3400995240 260 L>R No EVA
rs3400644090 262 E>V No EVA
rs3400933296 264 T>GLL* No EVA
rs49033566 267 H>Q No EVA
rs48766212 305 S>N No EVA
rs256703418 312 T>M No EVA
rs3389088199 413 Q>P No EVA
rs242382190 414 L>S No EVA
rs3389091382 488 K>* No EVA
rs3389067266 493 T>N No EVA
rs3411016182 531 V>I No EVA
rs3389088173 541 L>P No EVA
rs257060773 579 T>I No EVA
rs3389091409 590 L>M No EVA
rs3389098995 593 F>V No EVA
rs3389082093 641 F>I No EVA
rs212937079 651 H>N No EVA
rs3400303692 715 A>D No EVA
rs230959080 739 V>M No EVA
rs261324840 744 A>P No EVA
rs221436688 761 I>V No EVA
rs3400759710 773 D>V No EVA
rs3400856316 773 D>Y No EVA
rs3400836419 779 P>A No EVA
rs3399755480 780 N>K No EVA
rs3400932289 781 F>V No EVA
rs3400855619 782 E>G No EVA
rs3400856282 783 P>Q No EVA
rs249652832 783 P>S No EVA
rs3400759705 909 A>V No EVA
rs262518222 936 V>A No EVA
rs227950191 941 T>A No EVA
rs583834899 945 I>V No EVA
rs580268384 947 A>P No EVA
rs254757003 948 V>L No EVA
rs222785434 950 E>D No EVA
rs46346093 1157 T>A No EVA
rs260965043 1166 V>I No EVA
rs245353500 1192 P>S No EVA
rs226905284 1237 I>M No EVA
rs245325427 1246 T>M No EVA
rs252881475 1300 S>F No EVA
rs214343469 1312 V>M No EVA
rs51409405 1421 V>A No EVA
rs228907562 1451 D>G No EVA
rs265609418 1455 Y>D No EVA
rs230552490 1464 N>S No EVA
rs230552490 1464 N>T No EVA
rs50179599 1474 W>C No EVA
rs263299858 1537 A>T No EVA
rs258462288 1565 H>Y No EVA
rs256308357 1611 V>E No EVA

No associated diseases with G3UZ78

2 regional properties for G3UZ78

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 905 - 934 IPR000048
domain Peptidase C2, calpain, catalytic domain 98 - 292 IPR001300

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium, flagellum
  • Expressed within the midpiece and along the whole sperm flagellum (PubMed:35700329)
  • Detected in the annulus of the sperm flagellum in S12 and S15 spermatids and mature sperm (PubMed:35700329)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
sperm annulus The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
sperm midpiece The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.

3 GO annotations of molecular function

Name Definition
calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
oxygen binding Binding to oxygen (O2).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27970 CAPN1 Calpain-1 catalytic subunit Bos taurus (Bovine) PR
Q27971 CAPN2 Calpain-2 catalytic subunit Bos taurus (Bovine) PR
P00789 Calpain-1 catalytic subunit Gallus gallus (Chicken) PR
Q9VXH6 CalpC Calpain-C Drosophila melanogaster (Fruit fly) PR
O14815 CAPN9 Calpain-9 Homo sapiens (Human) PR
Q6MZZ7 CAPN13 Calpain-13 Homo sapiens (Human) PR
Q9HC96 CAPN10 Calpain-10 Homo sapiens (Human) PR
P07384 CAPN1 Calpain-1 catalytic subunit Homo sapiens (Human) PR
O35350 Capn1 Calpain-1 catalytic subunit Mus musculus (Mouse) PR
Q9ESK3 Capn10 Calpain-10 Mus musculus (Mouse) PR
O08529 Capn2 Calpain-2 catalytic subunit Mus musculus (Mouse) PR
Q9D805 Capn9 Calpain-9 Mus musculus (Mouse) PR
Q3UW68 Capn13 Calpain-13 Mus musculus (Mouse) PR
P35750 CAPN1 Calpain-1 catalytic subunit Sus scrofa (Pig) PR
P43367 CAPN2 Calpain-2 catalytic subunit Sus scrofa (Pig) PR
O35920 Capn9 Calpain-9 Rattus norvegicus (Rat) PR
P97571 Capn1 Calpain-1 catalytic subunit Rattus norvegicus (Rat) PR
Q5BK10 Capn13 Calpain-13 Rattus norvegicus (Rat) PR
Q07009 Capn2 Calpain-2 catalytic subunit Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASKQAKRKE VHRINSAHGS DKSKDLYHFG SNVPPGSFEQ KKGKFPIWPE WSEADINAEK
70 80 90 100 110 120
WDAGKGGKEK DKTAKSPIFH FFEDPEGKIE LPQSLKVFSW KRPQDFIFSR TPVVVKNEIT
130 140 150 160 170 180
FDLFSPNEHL LCSELMRWII SEIYAVWKIF NGGILSNYHK GNLGELPILP WKPWEHIYSL
190 200 210 220 230 240
CKAVKGHVPL FNSYGKYVVK LYWMGCWRKI TVDDFLPFDE ENNLLLPATS YEFELWPMLL
250 260 270 280 290 300
SKAIIKLANV DVHVAHRREL GELTVIHALT GWLPEVIPLH PAYVDRVWEL LKEILPEFKL
310 320 330 340 350 360
TEEPSSESKI TTIDNKLKEA TKENKDGKDG KNGKDLKDGK DMKDGKDGKD GKDGKDGKDG
370 380 390 400 410 420
KDEKADARDL GKKNKKDGEK EKEKFKFSLH GSRPSSDVQY SMQSLSECSS AIQLPHMVVY
430 440 450 460 470 480
ATFTPLYLFE NKIFSLEKMA NSAEKLREYG LSHICSHPVL VTRSRSCPLV SPPKPPPLPA
490 500 510 520 530 540
WKLIRHKKET VITDEAQDAV PKKPEQFLEI SSPFLNYRMT PFTIPTETHF VQSVIKKGTP
550 560 570 580 590 600
LGSSLPPLVE NDLVASTSQG EMSIVNGNQS QGNIALQITL GKDEPSEPAL ADFHQLEATS
610 620 630 640 650 660
LDRDLISLTT ATLDKSQEEL AINEGVAKEI WLDFEDFCVC FHHIYIFHKP HSYCLNFQKS
670 680 690 700 710 720
EFKFVEERVP YYLFVDSLKP IELLVCFSAL VRWGESGALT KDSPPVEPGL LTAEAITWKS
730 740 750 760 770 780
LKPLSVVLRI HTYATKASVV RLPAGRHMLL FNAYSPVGHA IHVCSMTTFV IGDEDIVLPN
790 800 810 820 830 840
FEPESYRFTE QSIIIMKAIG NVIANFKDKG KLPAALRDLQ AAHYPIPLNN KELTAQHFRV
850 860 870 880 890 900
FHISLWRLMK KSQVAKPPSN FKFAFRAMVF DTDLLDSFSE DVSLAEWVDL KYSTPINEKE
910 920 930 940 950 960
YTSEEIAAAV KIQSMWKGCY VRLLMKARKP ETKENVTVAD TLQKIWAVLE MNLEQYALSL
970 980 990 1000 1010 1020
LRLMFKSKCK SMESYPCYQD EETKLAFADH TVNYADQPPN SWFIVFREIF LVPQDMIILP
1030 1040 1050 1060 1070 1080
KVYTTLPICI LHVINNDTLE QVPKVFQKVV PFLYTKNKKG YTFVAEAYTG DTFVSGARWK
1090 1100 1110 1120 1130 1140
LRLIGSYNPL PFLARDSPCN TFSIKEIRDY YIPNDRKILF RYSIKVTVAQ SITIQVRTSK
1150 1160 1170 1180 1190 1200
PDTFIKLQVL ESEEVITSTV GKGQAVIPAF YFLGNEKALS SQSSKQVLLS HPSPKKDPEV
1210 1220 1230 1240 1250 1260
LTKKKSGQPG QKSFKGRSGG GLTDTGMPLL EEEILNIPTL EENSSTPQQC YKYIIQCLVL
1270 1280 1290 1300 1310 1320
FNSWPLNETQ LTFVQALKDM EKMDIKEKHE EPAPMGSPDS HAVSEGQKSV GVPKTTRKGK
1330 1340 1350 1360 1370 1380
EKSAEKEKLA KEKQAPRFEP QQVQMPTAVH SQQEDPNKPY WILRLVSEHT DSDYVDVKKD
1390 1400 1410 1420 1430 1440
TERADEIRAM KQAWETTEPG RAIKAAQARL KYLTQFIKKP VTTDTTTSAP SPETLSVSQS
1450 1460 1470 1480 1490 1500
QTKSSEEGEL DTGKYADIKE LPPNAAGSVL WKKWQMTKTI TSLTKFTSSE SVPKEEPPQK
1510 1520 1530 1540 1550 1560
EIPVVRQRSP TILETSPQQI RKALEFLDFS HYVRKTAAEA VLQTEELNKQ QAMQKAEEIH
1570 1580 1590 1600 1610 1620
QFRQHRSRIL SIRDIDQEER FKQKDEVLEM YGEMRDSVDE ARQKILDIRE VYRNKLLEAE
1630 1640 1650
RLRMEALAAQ EAAVKIEIEK KSPASDSQKK KKVGKKK