P35750
Gene name |
CAPN1 |
Protein name |
Calpain-1 catalytic subunit |
Names |
Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain, muCANP |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397027 |
EC number |
3.4.22.52: Cysteine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35750
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35750-F1 | Predicted | AlphaFoldDB |
No variants for P35750
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P35750 | |||||
No associated diseases with P35750
8 regional properties for P35750
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 109 - 120 | IPR000169 |
| domain | Peptidase C2, calpain, catalytic domain | 37 - 362 | IPR001300 |
| domain | EF-hand domain | 557 - 614 | IPR002048-1 |
| domain | EF-hand domain | 615 - 650 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 628 - 640 | IPR018247 |
| domain | Peptidase C2, calpain, large subunit, domain III | 371 - 514 | IPR022682 |
| domain | Peptidase C2, calpain, domain III | 365 - 522 | IPR022683 |
| domain | Calpain subdomain III | 366 - 524 | IPR033883 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.22.52 | Cysteine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent cysteine-type endopeptidase activity | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
| self proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27971 | CAPN2 | Calpain-2 catalytic subunit | Bos taurus (Bovine) | PR |
| Q27970 | CAPN1 | Calpain-1 catalytic subunit | Bos taurus (Bovine) | PR |
| P00789 | Calpain-1 catalytic subunit | Gallus gallus (Chicken) | PR | |
| Q9VXH6 | CalpC | Calpain-C | Drosophila melanogaster (Fruit fly) | PR |
| O14815 | CAPN9 | Calpain-9 | Homo sapiens (Human) | PR |
| Q6MZZ7 | CAPN13 | Calpain-13 | Homo sapiens (Human) | PR |
| Q9HC96 | CAPN10 | Calpain-10 | Homo sapiens (Human) | PR |
| P07384 | CAPN1 | Calpain-1 catalytic subunit | Homo sapiens (Human) | PR |
| Q9ESK3 | Capn10 | Calpain-10 | Mus musculus (Mouse) | PR |
| G3UZ78 | Adgb | Androglobin | Mus musculus (Mouse) | PR |
| O08529 | Capn2 | Calpain-2 catalytic subunit | Mus musculus (Mouse) | PR |
| Q9D805 | Capn9 | Calpain-9 | Mus musculus (Mouse) | PR |
| Q3UW68 | Capn13 | Calpain-13 | Mus musculus (Mouse) | PR |
| O35350 | Capn1 | Calpain-1 catalytic subunit | Mus musculus (Mouse) | PR |
| P43367 | CAPN2 | Calpain-2 catalytic subunit | Sus scrofa (Pig) | PR |
| O35920 | Capn9 | Calpain-9 | Rattus norvegicus (Rat) | PR |
| Q5BK10 | Capn13 | Calpain-13 | Rattus norvegicus (Rat) | PR |
| Q07009 | Capn2 | Calpain-2 catalytic subunit | Rattus norvegicus (Rat) | PR |
| P97571 | Capn1 | Calpain-1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEEVITPVY | CTGVSAQVQK | LRAKELGLGR | HENAIKYLGQ | DYEQLRAHCL | QSGSLFRDEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPPVPQSLGF | KELGPNSSKT | YGVKWKRPTE | LFSNPQFIVD | GATRTDICQG | ALGDCWLLAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IASLTLNDTL | LHRVVPHGQS | FQNGYAGIFH | FQLWQFGEWV | DVVVDDLLPT | KDGKLVFVHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AQGNEFWSAL | LEKAYAKVNG | SYEALSGGST | SEGFEDFTGG | VTEWYELRKA | PSDLYSIILK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALERGSLLGC | SIDISSVLDM | EAVTFKKLVK | GHAYSVTGAK | QVNYQGQMVN | LIRMRNPWGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEWTGAWSDG | SSEWNGVDPY | QRDQLRVRME | DGEFWMSFRD | FLREFTRLEI | CNLTPDALKS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QRVRNWNTTL | YEGTWRRGST | AGGCRNYPAT | FWVNPQFKIR | LEETDDPEDD | YGGRESGCSF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLALMQKHRR | RERRFGRDME | TIGFAVYEVP | PELVGQPVHL | KRDFFLANAS | RARSEQFINL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REVSTRFRLP | PGEYVVVPST | FEPNKEGDFV | LRFFSEKKAG | TQELDDQVQA | ILPDEQVLSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEIDENFKAL | FRQLAGEDME | ISVRELRTIL | NRIISKHKDL | RTKGFSLESC | RSMVNLMDRD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GNGKLGLVEF | NILWNRIRNY | LSIFRKFDLD | KSGSMSAYEM | RMAIESAGFK | LNKKLFELII |
| 670 | 680 | 690 | 700 | 710 | |
| TRYSEPDLAV | DFDNFVCCLV | RLETMFRFFK | TLDTDLDGVV | TFDLFKWLQL | TMFA |