P00789

PR
Gene name
Protein name
Calpain-1 catalytic subunit
Names
Calcium-activated neutral proteinase, CANP, Calpain-1 large subunit, Mu/M-type
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396240
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P00789

Entry ID Method Resolution Chain Position Source
AF-P00789-F1 Predicted AlphaFoldDB

68 variants for P00789

Variant ID(s) Position Change Description Diseaes Association Provenance
rs741648707 3 P>A No Ensembl
rs734164261 23 E>K No Ensembl
rs741074229 66 L>P No Ensembl
rs734962133 69 Y>S No Ensembl
rs732606718 78 W>G No Ensembl
rs735753495 113 A>G No Ensembl
rs739207395 116 S>P No Ensembl
rs738580220 117 L>P No Ensembl
rs735512819 118 T>P No Ensembl
rs738331118 123 L>P No Ensembl
rs732208264 125 H>P No Ensembl
rs1058013813 144 F>S No Ensembl
rs14334188 153 V>E No Ensembl
rs14334189 153 V>L No Ensembl
rs733227325 156 V>G No Ensembl
rs14334185 160 L>Q No Ensembl
rs736681852 163 T>P No Ensembl
rs14334181 167 E>K No Ensembl
rs14334173 176 C>G No Ensembl
rs732322191 188 Y>S No Ensembl
rs14334169 191 L>V No Ensembl
rs14334164 197 S>A No Ensembl
rs1058902108 197 S>L No Ensembl
rs14334160 204 T>S No Ensembl
rs736227982 209 D>G No Ensembl
rs739013967 214 V>G No Ensembl
rs14334154 215 A>T No Ensembl
rs14334151 217 M>R No Ensembl
rs14334152 217 M>V No Ensembl
rs740175389 220 L>R No Ensembl
rs14334148 221 K>E No Ensembl
rs14334147 221 K>T No Ensembl
rs14334146 222 R>Q No Ensembl
rs14334140 227 M>I No Ensembl
rs14334141 227 M>L No Ensembl
rs14334139 228 G>C No Ensembl
rs14334138 228 G>D No Ensembl
rs738159357 229 H>P No Ensembl
rs14334137 229 H>Q No Ensembl
rs738653208 262 V>G No Ensembl
rs741470688 270 T>P No Ensembl
rs733007514 294 V>G No Ensembl
rs738039693 311 D>A No Ensembl
rs1060129251 377 C>Y No Ensembl
rs315404325 382 A>D No Ensembl
rs1059673559 404 D>G No Ensembl
rs1058653704 411 L>F No Ensembl
rs737830433 412 V>G No Ensembl
rs1058163109 414 L>P No Ensembl
rs731700358 421 R>G No Ensembl
rs734842225 422 E>G No Ensembl
rs1058588206 428 D>G No Ensembl
rs1058010737 429 M>I No Ensembl
rs1058906123 430 H>P No Ensembl
rs734088074 442 E>G No Ensembl
rs737351141 472 R>G No Ensembl
rs732991442 506 T>P No Ensembl
rs1059111797 520 S>L No Ensembl
rs317048601 569 K>R No Ensembl
rs733739473 579 D>A No Ensembl
rs738674478 591 D>E No Ensembl
rs731190266 593 S>R No Ensembl
rs1057674948 595 R>H No Ensembl
rs740106030 599 V>G No Ensembl
rs736859007 650 V>G No Ensembl
rs735181722 651 V>G No Ensembl
rs1059838143 659 T>M No Ensembl
rs736589883 671 V>G No Ensembl

No associated diseases with P00789

7 regional properties for P00789

Type Name Position InterPro Accession
active_site Cysteine peptidase, cysteine active site 102 - 113 IPR000169
domain Peptidase C2, calpain, catalytic domain 30 - 355 IPR001300
domain EF-hand domain 606 - 641 IPR002048
binding_site EF-Hand 1, calcium-binding site 619 - 631 IPR018247
domain Peptidase C2, calpain, large subunit, domain III 364 - 505 IPR022682
domain Peptidase C2, calpain, domain III 358 - 513 IPR022683
domain Calpain subdomain III 358 - 515 IPR033883

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Translocates to the plasma membrane upon Ca(2+) binding
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27971 CAPN2 Calpain-2 catalytic subunit Bos taurus (Bovine) PR
Q27970 CAPN1 Calpain-1 catalytic subunit Bos taurus (Bovine) PR
Q9VXH6 CalpC Calpain-C Drosophila melanogaster (Fruit fly) PR
O14815 CAPN9 Calpain-9 Homo sapiens (Human) PR
Q6MZZ7 CAPN13 Calpain-13 Homo sapiens (Human) PR
Q9HC96 CAPN10 Calpain-10 Homo sapiens (Human) PR
P07384 CAPN1 Calpain-1 catalytic subunit Homo sapiens (Human) PR
Q9ESK3 Capn10 Calpain-10 Mus musculus (Mouse) PR
G3UZ78 Adgb Androglobin Mus musculus (Mouse) PR
O08529 Capn2 Calpain-2 catalytic subunit Mus musculus (Mouse) PR
Q9D805 Capn9 Calpain-9 Mus musculus (Mouse) PR
Q3UW68 Capn13 Calpain-13 Mus musculus (Mouse) PR
O35350 Capn1 Calpain-1 catalytic subunit Mus musculus (Mouse) PR
P43367 CAPN2 Calpain-2 catalytic subunit Sus scrofa (Pig) PR
P35750 CAPN1 Calpain-1 catalytic subunit Sus scrofa (Pig) PR
O35920 Capn9 Calpain-9 Rattus norvegicus (Rat) PR
Q5BK10 Capn13 Calpain-13 Rattus norvegicus (Rat) PR
Q07009 Capn2 Calpain-2 catalytic subunit Rattus norvegicus (Rat) PR
P97571 Capn1 Calpain-1 catalytic subunit Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MMPFGGIAAR LQRDRLRAEG VGEHNNAVKY LNQDYEALKQ ECIESGTLFR DPQFPAGPTA
70 80 90 100 110 120
LGFKELGPYS SKTRGVEWKR PSELVDDPQF IVGGATRTDI CQGALGDCWL LAAIGSLTLN
130 140 150 160 170 180
EELLHRVVPH GQSFQEDYAG IFHFQIWQFG EWVDVVVDDL LPTKDGELLF VHSAECTEFW
190 200 210 220 230 240
SALLEKAYAK LNGCYESLSG GSTTEGFEDF TGGVAEMYDL KRAPRNMGHI IRKALERGSL
250 260 270 280 290 300
LGCSIDITSA FDMEAVTFKK LVKGHAYSVT AFKDVNYRGQ QEQLIRIRNP WGQVEWTGAW
310 320 330 340 350 360
SDGSSEWDNI DPSDREELQL KMEDGEFWMS FRDFMREFSR LEICNLTPDA LTKDELSRWH
370 380 390 400 410 420
TQVFEGTWRR GSTAGGCRNN PATFWINPQF KIKLLEEDDD PGDDEVACSF LVALMQKHRR
430 440 450 460 470 480
RERRVGGDMH TIGFAVYEVP EEAQGSQNVH LKKDFFLRNQ SRARSETFIN LREVSNQIRL
490 500 510 520 530 540
PPGEYIVVPS TFEPHKEADF ILRVFTEKQS DTAELDEEIS ADLADEEEIT EDDIEDGFKN
550 560 570 580 590 600
MFQQLAGEDM EISVFELKTI LNRVIARHKD LKTDGFSLDS CRNMVNLMDK DGSARLGLVE
610 620 630 640 650 660
FQILWNKIRS WLTIFRQYDL DKSGTMSSYE MRMALESAGF KLNNKLHQVV VARYADAETG
670 680 690 700
VDFDNFVCCL VKLETMFRFF HSMDRDGTGT AVMNLAEWLL LTMCG