Q8BFY6

PR
Gene name
Pef1
Protein name
Peflin
Names
PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67898
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BFY6

Entry ID Method Resolution Chain Position Source
AF-Q8BFY6-F1 Predicted AlphaFoldDB

10 variants for Q8BFY6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs237008483 6 N>D No EVA
rs3388716976 38 S>I No EVA
rs3388714827 42 P>R No EVA
rs3388721931 73 G>D No EVA
rs3388707786 119 A>V No EVA
rs3388713848 137 S>F No EVA
rs3388721932 144 D>G No EVA
rs3394760867 148 L>H No EVA
rs3388711206 224 S>Y No EVA
rs3388719597 241 L>M No EVA

No associated diseases with Q8BFY6

4 regional properties for Q8BFY6

Type Name Position InterPro Accession
domain EF-hand domain 105 - 174 IPR002048-1
domain EF-hand domain 172 - 207 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 118 - 130 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 185 - 197 IPR018247-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endoplasmic reticulum
  • Membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein
  • Membrane-associated in the presence of Ca(2+) (By similarity)
  • Localizes to endoplasmic reticulum exit site (ERES) (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

6 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium.
identical protein binding Binding to an identical protein or proteins.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
ubiquitin ligase-substrate adaptor activity The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.

6 GO annotations of biological process

Name Definition
COPII vesicle coating The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
neural crest formation The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
positive regulation of protein monoubiquitination Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6MZZ7 CAPN13 Calpain-13 Homo sapiens (Human) PR
P28676 GCA Grancalcin Homo sapiens (Human) PR
Q9UBV8 PEF1 Peflin Homo sapiens (Human) PR
Q3UW68 Capn13 Calpain-13 Mus musculus (Mouse) PR
Q5BK10 Capn13 Calpain-13 Rattus norvegicus (Rat) PR
Q641Z8 Pef1 Peflin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASYPNGQSC PGAAGQVPGV PPGGYYPGPP HGGGQYGSGL PPGGGYGAPA PGGPYGYPSA
70 80 90 100 110 120
GGVPSGTPSG PYGGIPPGGP YGQLPPGGPY GTQPGHYGQG GVPPNVDPEA YSWFQSVDAD
130 140 150 160 170 180
HSGYISLKEL KQALVNSNWS SFNDETCLMM INMFDKTKSG RIDVAGFSAL WKFLQQWRNL
190 200 210 220 230 240
FQQYDRDRSG SISSTELQQA LSQMGYNLSP QFTQLLVSRY CARSAIPAMQ LDCFIKVCTQ
250 260 270
LQVLTEAFRE KDTAVQGNIR LSFEDFVTMT ASRML