AiPD: Autoinhibited Protein Database

Q9UBV8

Gene name	PEF1
Protein name	Peflin
Names	PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:553115
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-130 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-130 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UBV8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UBV8-F1	Predicted				AlphaFoldDB

246 variants for Q9UBV8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA339592541 rs1262928168	2	A>T		No	ClinGen gnomAD
CA20192578 rs764113135	3	S>C		No	ClinGen ExAC TOPMed gnomAD
rs764113135 CA732460	3	S>G		No	ClinGen ExAC TOPMed gnomAD
CA339592532 rs760759780	3	S>R		No	ClinGen ExAC TOPMed gnomAD
rs764113135 CA732459	3	S>R		No	ClinGen ExAC TOPMed gnomAD
rs767723197 CA339592529	4	Y>C		No	ClinGen ExAC gnomAD
rs140479455 CA732456	4	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs140479455 CA339592530	4	Y>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA732455 rs767723197	4	Y>S		No	ClinGen ExAC gnomAD
rs141265870 CA732453	5	P>S		No	ClinGen ESP ExAC gnomAD
rs771358083 CA732452	6	Y>*		No	ClinGen ExAC gnomAD
CA339592513 rs1454103643	7	R>G		No	ClinGen gnomAD
CA732451 rs540821693	7	R>P		No	ClinGen ExAC TOPMed gnomAD
CA339592511 rs540821693	7	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA339592512 rs1454103643	7	R>W		No	ClinGen gnomAD
TCGA novel	8	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA732450 rs773868133	8	Q>R		No	ClinGen ExAC gnomAD
rs1306837647 CA339591914	11	P>Q		No	ClinGen gnomAD
rs949458541 CA339591918	11	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs949458541 CA20185570	11	P>T		No	ClinGen gnomAD
rs867319495 CA20185562	12	G>R		No	ClinGen gnomAD
rs1234874661 CA339591901	14	A>T		No	ClinGen TOPMed gnomAD
CA339591877 rs1295374474	17	A>V		No	ClinGen gnomAD
CA339591871 rs1356394145	18	P>L		No	ClinGen gnomAD
CA732428 rs768248106	19	G>A		No	ClinGen ExAC gnomAD
rs1398738320 CA339591865	20	A>T		No	ClinGen gnomAD
CA732425 rs202217061 COSM1341733	22	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs771699009 CA732424	25	Y>C		No	ClinGen ExAC gnomAD
rs1475753291 CA339591826	26	Y>H		No	ClinGen gnomAD
rs1417544737 CA339591819	27	P>T		No	ClinGen gnomAD
rs1440283860 CA339591805	29	P>S		No	ClinGen gnomAD
CA339591799 rs1398540135	30	P>R		No	ClinGen gnomAD
rs142951278 CA339591800	30	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142951278 CA732421	30	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA732419 rs781083110	31	N>H		No	ClinGen ExAC gnomAD
rs368906197 CA732418	31	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763321866 CA732415	36	Y>*		No	ClinGen ExAC gnomAD
CA339591759 rs1242953431	36	Y>C		No	ClinGen TOPMed gnomAD
CA339591754 rs1192027286	37	G>R		No	ClinGen TOPMed
rs1307845734 CA339591746	38	S>N		No	ClinGen gnomAD
rs201449486 CA732413	40	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA339591724 rs1475319446	42	P>A		No	ClinGen TOPMed gnomAD
rs777221074 CA732411	42	P>L		No	ClinGen ExAC gnomAD
rs375817960 CA732410	43	G>A		No	ClinGen ESP ExAC gnomAD
rs1223053516 CA339591720	43	G>S		No	ClinGen TOPMed
CA732409 rs149013148	46	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA339591696 rs1365153595	47	G>R		No	ClinGen gnomAD
rs1181970670 CA339591688	48	G>C		No	ClinGen gnomAD
rs1438567452 CA339591687	48	G>D		No	ClinGen gnomAD
TCGA novel	50	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA732404 COSM1341732 rs745569188	53	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA20185429 rs952375748	54	P>T		No	ClinGen Ensembl
rs369188697 CA732400	57	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1239645955 CA339591633	57	P>L		No	ClinGen gnomAD
CA732401 rs369188697	57	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA20185416 rs11551772	58	P>L		No	ClinGen Ensembl
rs1374773204 CA339591630	58	P>S		No	ClinGen gnomAD
CA339591615 rs1305647778	61	G>R		No	ClinGen TOPMed gnomAD
rs1402785884 CA339591591	64	Y>*		No	ClinGen gnomAD
CA732398 rs756072857	64	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA20185380 rs965120879	66	H>D		No	ClinGen TOPMed
TCGA novel	68	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1386072034 CA339591569	68	N>H		No	ClinGen gnomAD
CA732397 rs540510395	68	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA339591563 rs1418651930	69	P>A		No	ClinGen gnomAD
rs780044590 CA732396	73	P>H		No	ClinGen ExAC gnomAD
rs780044590 CA20185357	73	P>R		No	ClinGen ExAC gnomAD
rs141771149 CA732394	79	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757713580 CA732392	81	Y>H		No	ClinGen ExAC gnomAD
CA339591483 rs1409767499	82	G>S		No	ClinGen TOPMed
TCGA novel	82	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA732389 COSM908165 rs761145394	83	G>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1344988932 CA339591472	84	A>T		No	ClinGen gnomAD
CA20185262 rs201448518	84	A>V		No	ClinGen gnomAD
rs767054971 CA339591464	85	A>D		No	ClinGen ExAC TOPMed gnomAD
rs767054971 CA732387	85	A>V		No	ClinGen ExAC TOPMed gnomAD
rs149304800 CA339591462	86	P>A		No	ClinGen ESP TOPMed gnomAD
rs149304800 CA20185253 COSM3711316	86	P>S	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
CA732385 rs774005967	87	G>R		No	ClinGen ExAC gnomAD
rs1000901823 CA20185226	88	G>D		No	ClinGen Ensembl
CA732384 rs145077126	90	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749103112 CA20185218	92	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1203493522 CA339591425	92	Q>P		No	ClinGen TOPMed
rs772934269 CA732382	93	P>S		No	ClinGen ExAC gnomAD
CA20185212 rs200144237	94	P>S		No	ClinGen 1000Genomes TOPMed
rs200144237 CA339591415	94	P>T		No	ClinGen 1000Genomes TOPMed
rs1014100052 CA20185194	96	S>G		No	ClinGen TOPMed gnomAD
rs1302766166 CA339591401	96	S>N		No	ClinGen TOPMed
CA339591398 rs1447617728	97	S>T		No	ClinGen TOPMed
rs748072690 CA732380	98	Y>C		No	ClinGen ExAC gnomAD
CA339591391 rs1307641250	98	Y>H		No	ClinGen gnomAD
rs1487455960 CA339591385	99	G>S		No	ClinGen gnomAD
rs746034322 CA732377	102	Q>H		No	ClinGen ExAC gnomAD
CA732376 rs779283966	104	G>R		No	ClinGen ExAC gnomAD
rs374031460 CA732375	105	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA339591328 rs374031460	105	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs370676228 CA20185153	105	L>R		No	ClinGen ESP TOPMed
rs779582221 CA732348	109	G>V		No	ClinGen ExAC TOPMed gnomAD
rs557572685 CA732347	110	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1379827108 CA339591103	110	G>V		No	ClinGen gnomAD
CA339591102 rs140595911	111	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA732346 rs140595911	111	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA732345 rs750063064	112	P>S		No	ClinGen ExAC TOPMed gnomAD
rs765028173 CA732343	114	N>S		No	ClinGen ExAC TOPMed gnomAD
rs761519578 CA732342	115	V>A		No	ClinGen ExAC gnomAD
TCGA novel	116	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA732340 rs749930655	120	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA732339 rs760744671	121	S>P		No	ClinGen ExAC gnomAD
CA732337 rs774542516	122	W>C		No	ClinGen ExAC gnomAD
rs770948880 CA732336	124	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA339590967 rs1365240115	124	Q>K		No	ClinGen gnomAD
CA339590949 rs1400913518	125	S>L		No	ClinGen TOPMed gnomAD
CA339590948 rs1296477248	126	V>M		No	ClinGen TOPMed gnomAD
CA20183872 rs1031650486	127	D>N		No	ClinGen TOPMed
CA732334 rs777861045	131	S>G		No	ClinGen ExAC TOPMed gnomAD
rs770119323 CA732333	132	G>S		No	ClinGen ExAC gnomAD
CA339590858 rs1422171269	133	Y>*		No	ClinGen gnomAD
CA732331 rs781584359	133	Y>C		No	ClinGen ExAC gnomAD
CA20183830 rs998800886	136	M>I		No	ClinGen TOPMed
rs752087793 CA732329	136	M>T		No	ClinGen ExAC gnomAD
rs1488439627 CA339590831	136	M>V		No	ClinGen gnomAD
rs757856977 CA732327	138	E>D		No	ClinGen ExAC gnomAD
CA20183804 rs1043312412	140	K>R		No	ClinGen TOPMed gnomAD
CA339590777 rs1245303517	142	A>S		No	ClinGen TOPMed gnomAD
rs750028128 CA732326	145	N>D		No	ClinGen ExAC gnomAD
rs1310364579 CA339590755	146	C>R		No	ClinGen gnomAD
rs1047852178 CA20183787	147	N>H		No	ClinGen Ensembl
rs143340788 CA732325	147	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339590736 rs1218990837	148	W>*		No	ClinGen TOPMed gnomAD
CA20183774 rs757232708	148	W>S		No	ClinGen Ensembl
rs1339544502 CA339590717	151	F>S		No	ClinGen gnomAD
CA339590707 CA339590708 rs1416786604	152	N>K		No	ClinGen gnomAD
CA20183773 rs373796290	152	N>S		No	ClinGen ESP TOPMed gnomAD
rs756996122 CA339590699	153	D>E		No	ClinGen ExAC gnomAD
rs1302324356 CA339590687	155	T>N		No	ClinGen gnomAD
rs1570270271 CA339590689	155	T>P		No	ClinGen Ensembl
CA339590674 rs1356760970	157	L>F		No	ClinGen gnomAD
CA339590671 rs1215298204	157	L>R		No	ClinGen TOPMed
CA732322 rs753666924	158	M>T		No	ClinGen ExAC
CA339590649 rs1477715410	160	I>T		No	ClinGen gnomAD
TCGA novel	161	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339590620 rs1265113837	162	M>I		No	ClinGen gnomAD
CA339590622 rs1557584621	162	M>T		No	ClinGen Ensembl
CA339590626 rs1234886671	162	M>V		No	ClinGen TOPMed gnomAD
rs1242793392 CA339590605	164	D>G		No	ClinGen TOPMed gnomAD
CA339590600 rs1487926990	165	K>E		No	ClinGen TOPMed
rs763935107 CA339590570	169	G>A		No	ClinGen ExAC gnomAD
CA732304 rs763935107	169	G>D		No	ClinGen ExAC gnomAD
rs1375287373 CA339590566	170	R>C		No	ClinGen gnomAD
rs147722531 CA732303 COSM314085	170	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs752605388 CA732302	171	I>F		No	ClinGen ExAC gnomAD
rs752605388 CA339590562	171	I>V		No	ClinGen ExAC gnomAD
CA732299 rs773134257	172	D>G		No	ClinGen ExAC gnomAD
CA732300 rs759567297 COSM3419112	172	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765386131 CA732298	174	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA732296 rs776849452	175	G>S		No	ClinGen ExAC
rs1570268797 CA339590511	179	L>P		No	ClinGen Ensembl
rs1266334678 CA339590499	181	K>E		No	ClinGen gnomAD
CA732292 rs772440392	181	K>N		No	ClinGen ExAC gnomAD
CA732291 rs146809023	182	F>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369403984 CA20183268	183	I>V		No	ClinGen ESP TOPMed
CA339590478 rs1557584492	184	Q>E		No	ClinGen Ensembl
CA732290 rs778246626	184	Q>R		No	ClinGen ExAC gnomAD
rs1277153576 CA339590466	185	Q>H		No	ClinGen gnomAD
rs1351537862 CA339590467	185	Q>L		No	ClinGen gnomAD
rs756851161 CA732289	186	W>R		No	ClinGen ExAC gnomAD
rs1330901786 CA339590444	188	N>S		No	ClinGen gnomAD
CA339590424 rs1384790829	191	Q>*		No	ClinGen gnomAD
rs755887392 CA732286	192	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs781079521 CA732285	195	R>G		No	ClinGen ExAC TOPMed gnomAD
CA732283 rs140422275	195	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA732284 rs781079521	195	R>W		No	ClinGen ExAC TOPMed gnomAD
CA732282 rs751533337	197	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1196441365 CA339590382	197	R>H		No	ClinGen TOPMed gnomAD
CA732281 rs765240041	198	S>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	200	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA732280 rs144874149	201	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA20183139 rs887273963	208	Q>E		No	ClinGen TOPMed
CA339589909 rs201297417	211	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA732227 rs201297417	211	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA339589902 rs985013441	212	Q>H		No	ClinGen TOPMed
rs374586693 CA339589905	212	Q>P		No	ClinGen gnomAD
rs374586693 CA20182155	212	Q>R		No	ClinGen gnomAD
CA339589889 rs1199000368	214	G>A		No	ClinGen TOPMed
rs1426398480 CA339589886	215	Y>H		No	ClinGen gnomAD
rs778826617 CA732226	216	N>K		No	ClinGen ExAC gnomAD
rs1190948123 CA339589874	216	N>S		No	ClinGen gnomAD
rs953350614 CA20182143	218	S>G		No	ClinGen Ensembl
TCGA novel	222	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1488337185 CA339589829	222	T>I		No	ClinGen gnomAD
CA339589836 rs1570264867	222	T>P		No	ClinGen Ensembl
rs1203030784 CA339589811	224	L>V		No	ClinGen TOPMed
CA339589777 rs1213633075	227	S>F		No	ClinGen gnomAD
rs1313849281 CA339589771	228	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs139896724 CA732223	228	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1221334939 CA339589758	229	Y>S		No	ClinGen TOPMed
rs1218449835 CA339589750	230	C>S		No	ClinGen gnomAD
CA20182115 rs547542586	230	C>Y		No	ClinGen gnomAD
rs1280341427 CA339589735	231	P>A		No	ClinGen gnomAD
rs1280341427 CA339589733	231	P>S		No	ClinGen gnomAD
rs755186565 CA732222	232	R>C		No	ClinGen ExAC gnomAD
rs371830019 CA732221	232	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1287186849 CA339589708	233	S>F		No	ClinGen gnomAD
rs1228639770 CA339589717	233	S>P		No	ClinGen TOPMed
rs866571271 CA20182098	234	A>T		No	ClinGen Ensembl
rs758834965 CA732219	235	N>S		No	ClinGen ExAC gnomAD
rs569702331 CA20182085	237	A>P		No	ClinGen 1000Genomes
rs1468602435 CA339589662	238	M>T		No	ClinGen gnomAD
CA732218 rs549808725	238	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA732217 rs765758652	240	L>F		No	ClinGen ExAC gnomAD
rs780909453 CA732216	241	D>H		No	ClinGen ExAC gnomAD
CA732215 rs776178785	242	R>C		No	ClinGen ExAC TOPMed gnomAD
rs763547860 CA732214	242	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1019932391 CA20182059	243	F>L		No	ClinGen TOPMed gnomAD
CA339589593 rs1557583019	245	Q>R		No	ClinGen Ensembl
CA339589567 rs1256547111	247	C>*		No	ClinGen TOPMed gnomAD
rs1209253535 CA339589555	248	T>I		No	ClinGen gnomAD
CA339589558 rs1209253535	248	T>N		No	ClinGen gnomAD
CA339589546 rs1227258375	249	Q>P		No	ClinGen gnomAD
CA339589517 rs1321169406	252	V>L		No	ClinGen gnomAD
rs760275627 CA732212	254	T>R		No	ClinGen ExAC gnomAD
rs1570264402 CA339589474	256	A>S		No	ClinGen Ensembl
rs146006007 CA339589453	258	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs146006007 CA732210	258	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs775137790 CA732211	258	R>W		No	ClinGen ExAC TOPMed gnomAD
CA732209 rs745659069	259	E>K		No	ClinGen ExAC gnomAD
CA732208 rs774191997	260	K>E		No	ClinGen ExAC gnomAD
rs1175892699 CA339589408	262	T>A		No	ClinGen TOPMed
CA20181981 rs539499336	263	A>S		No	ClinGen 1000Genomes
CA732206 rs749213335	264	V>I		No	ClinGen ExAC gnomAD
CA732207 rs749213335	264	V>L		No	ClinGen ExAC gnomAD
rs781284157 CA732205	265	Q>*		No	ClinGen ExAC gnomAD
CA339589365 rs1443527794	266	G>D		No	ClinGen gnomAD
CA732204 rs768631094	267	N>S		No	ClinGen ExAC TOPMed gnomAD
CA339589333 rs1238516900	269	R>Q		No	ClinGen TOPMed
CA339589335 rs1465872048	269	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA20181956 rs922785030	273	E>K		No	ClinGen TOPMed gnomAD
CA339589268 rs1182964415	276	V>A		No	ClinGen gnomAD
CA732199 rs779189008	276	V>I		No	ClinGen ExAC TOPMed gnomAD
rs757745336 CA732198	277	T>A		No	ClinGen ExAC TOPMed gnomAD
CA339589255 CA732196 rs763606589	278	M>I		No	ClinGen ExAC TOPMed gnomAD
rs754327994 CA732197	278	M>V		No	ClinGen ExAC gnomAD
CA732195 rs760183446	279	T>I		No	ClinGen ExAC TOPMed gnomAD
CA339589247 rs760183446	279	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1247207063 CA339589220	282	R>Q		No	ClinGen gnomAD
rs937496556 COSM908160 CA20181929	282	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD

No associated diseases with Q9UBV8

3 regional properties for Q9UBV8

Type	Name	Position	InterPro Accession
conserved_site	Terpene synthase, conserved site	605 - 619	IPR002365
domain	Squalene cyclase, C-terminal	415 - 752	IPR032696
domain	Squalene cyclase, N-terminal	100 - 394	IPR032697

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Endoplasmic reticulum Membrane ; Peripheral membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein	Membrane-associated in the presence of Ca(2+) (PubMed:11278427) Localizes to endoplasmic reticulum exit site (ERES) (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
COPII vesicle coat	One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
Cul3-RING ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

7 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
calcium-dependent protein binding	Binding to a protein or protein complex in the presence of calcium.
identical protein binding	Binding to an identical protein or proteins.
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
RNA binding	Binding to an RNA molecule or a portion thereof.
ubiquitin ligase-substrate adaptor activity	The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.

6 GO annotations of biological process

Name	Definition
COPII vesicle coating	The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
endoplasmic reticulum to Golgi vesicle-mediated transport	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
neural crest cell development	The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
neural crest formation	The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
positive regulation of protein monoubiquitination	Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.
response to calcium ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6MZZ7	CAPN13	Calpain-13	Homo sapiens (Human)	PR
P28676	GCA	Grancalcin	Homo sapiens (Human)	PR
Q3UW68	Capn13	Calpain-13	Mus musculus (Mouse)	PR
Q8BFY6	Pef1	Peflin	Mus musculus (Mouse)	PR
Q5BK10	Capn13	Calpain-13	Rattus norvegicus (Rat)	PR
Q641Z8	Pef1	Peflin	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MASYPYRQGC	PGAAGQAPGA	PPGSYYPGPP	NSGGQYGSGL	PPGGGYGGPA	PGGPYGPPAG
70	80	90	100	110	120
GGPYGHPNPG	MFPSGTPGGP	YGGAAPGGPY	GQPPPSSYGA	QQPGLYGQGG	APPNVDPEAY
130	140	150	160	170	180
SWFQSVDSDH	SGYISMKELK	QALVNCNWSS	FNDETCLMMI	NMFDKTKSGR	IDVYGFSALW
190	200	210	220	230	240
KFIQQWKNLF	QQYDRDRSGS	ISYTELQQAL	SQMGYNLSPQ	FTQLLVSRYC	PRSANPAMQL
250	260	270	280
DRFIQVCTQL	QVLTEAFREK	DTAVQGNIRL	SFEDFVTMTA	SRML