O35316
PR
Gene name |
Slc6a6 (Taut) |
Protein name |
Sodium- and chloride-dependent taurine transporter |
Names |
Solute carrier family 6 member 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21366 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35316
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35316-F1 | Predicted | AlphaFoldDB |
28 variants for O35316
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388851143 | 46 | S>G | No | EVA | |
| rs3388840445 | 53 | S>Y | No | EVA | |
| rs3388835339 | 54 | V>A | No | EVA | |
| rs3396978881 | 64 | V>A | No | EVA | |
| rs3388835414 | 66 | R>H | No | EVA | |
| rs3388845344 | 83 | Y>N | No | EVA | |
| rs3388844021 | 92 | L>M | No | EVA | |
| rs3388835357 | 100 | I>T | No | EVA | |
| rs3388839660 | 129 | V>I | No | EVA | |
| rs3388850115 | 159 | W>R | No | EVA | |
| rs3388835404 | 165 | S>N | No | EVA | |
| rs3412920742 | 171 | C>Y | No | EVA | |
| rs3388848524 | 177 | R>S | No | EVA | |
| rs3388811422 | 291 | W>* | No | EVA | |
| rs3388811469 | 301 | S>F | No | EVA | |
| rs3388835400 | 379 | T>S | No | EVA | |
| rs3388840481 | 391 | F>Y | No | EVA | |
| rs3388835391 | 393 | I>V | No | EVA | |
| rs3388843905 | 396 | L>F | No | EVA | |
| rs3388848471 | 403 | Q>K | No | EVA | |
| rs3388840448 | 468 | L>P | No | EVA | |
| rs3388835337 | 512 | T>I | No | EVA | |
| rs3388845337 | 559 | L>W | No | EVA | |
| rs3388850183 | 575 | R>I | No | EVA | |
| rs3388811452 | 577 | K>N | No | EVA | |
| rs3388828304 | 584 | E>D | No | EVA | |
| rs3388843509 | 592 | R>H | No | EVA | |
| rs3388851118 | 595 | A>D | No | EVA |
No associated diseases with O35316
No regional properties for O35316
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O35316 | |||
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| microvillus membrane | The portion of the plasma membrane surrounding a microvillus. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasma membrane protein complex | Any protein complex that is part of the plasma membrane. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| alanine transmembrane transporter activity | Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. |
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| amino acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). |
| gamma-aminobutyric acid transmembrane transporter activity | Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| gamma-aminobutyric acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). |
| taurine binding | Binding to taurine. |
| taurine transmembrane transporter activity | Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. |
| taurine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| alanine transport | The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| gamma-aminobutyric acid import | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. |
| import across plasma membrane | The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol. |
| modulation of chemical synaptic transmission | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| nitrogen compound transport | The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of cell differentiation | Any process that activates or increases the frequency, rate or extent of cell differentiation. |
| positive regulation of necrotic cell death | Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| taurine transport | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| Q00589 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATKEKLQCL | KDFHKDILKP | SPGKSPGTRP | EDEADGKPPQ | REKWSSKIDF | VLSVAGGFVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGNVWRFPYL | CYKNGGGAFL | IPYFIFLFGS | GLPVFFLEVI | IGQYTSEGGI | TCWEKICPLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGIGYASIVI | VSLLNVYYIV | ILAWATYYLF | HSFQKDLPWA | HCNHSWNTPQ | CMEDTLRRNE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SHWVSLSTAN | FTSPVIEFWE | RNVLSLSSGI | DNPGSLKWDL | ALCLLLVWLV | CFFCIWKGVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STGKVVYFTA | TFPFAMLLVL | LVRGLTLPGA | GEGIKFYLYP | DISRLGDPQV | WIDAGTQIFF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SYAICLGAMT | SLGSYNKYKY | NSYRDCMLLG | CLNSGTSFVS | GFAIFSILGF | MAQEQGVDIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DVAESGPGLA | FIAYPKAVTM | MPLPTFWSIL | FFIMLLLLGL | DSQFVEVEGQ | ITSLVDLYPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLRKGYRREI | FIAILCSISY | LLGLTMVTEG | GMYVFQLFDY | YAASGVCLLW | VAFFECFVIA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WIYGGDNLYD | GIEDMIGYRP | GPWMKYSWAV | ITPALCVGCF | VFSLVKYVPL | TYNKVYRYPD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WAIGLGWGLA | LSSMLCIPLV | IVILLCRTEG | PLRVRIKYLI | TPREPNRWAV | EREGATPFHS |
| 610 | 620 | ||||
| RVTLMNGALM | KPSHVIVETM | M |