P31649
PR
Gene name |
Slc6a13 |
Protein name |
Sodium- and chloride-dependent GABA transporter 2 |
Names |
GAT-2, Sodium- and chloride-dependent GABA transporter 3, GAT-3, Solute carrier family 6 member 13 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14412 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P31649
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31649-F1 | Predicted | AlphaFoldDB |
26 variants for P31649
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388857572 | 24 | V>M | No | EVA | |
| rs242896218 | 31 | E>K | No | EVA | |
| rs3388841662 | 48 | E>K | No | EVA | |
| rs3388856588 | 60 | Y>C | No | EVA | |
| rs3388858835 | 136 | A>D | No | EVA | |
| rs3388864089 | 166 | Q>H | No | EVA | |
| rs3388841667 | 186 | F>I | No | EVA | |
| rs3388841679 | 197 | G>D | No | EVA | |
| rs3388821590 | 237 | T>R | No | EVA | |
| rs3388835024 | 283 | G>D | No | EVA | |
| rs3388834989 | 288 | F>S | No | EVA | |
| rs3388841671 | 381 | F>L | No | EVA | |
| rs3388841678 | 406 | Y>* | No | EVA | |
| rs3388864071 | 412 | K>R | No | EVA | |
| rs3388856534 | 428 | F>L | No | EVA | |
| rs3388854074 | 445 | L>P | No | EVA | |
| rs3388821560 | 450 | A>V | No | EVA | |
| rs3388864062 | 492 | I>F | No | EVA | |
| rs3388864062 | 492 | I>V | No | EVA | |
| rs3388855326 | 498 | F>L | No | EVA | |
| rs3388858823 | 529 | W>C | No | EVA | |
| rs3388850855 | 574 | L>H | No | EVA | |
| rs3388852801 | 584 | A>V | No | EVA | |
| rs3388858871 | 587 | T>A | No | EVA | |
| rs3397357919 | 594 | R>* | No | EVA | |
| rs3413138135 | 599 | E>V | No | EVA |
No associated diseases with P31649
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| amino acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). |
| creatine transmembrane transporter activity | Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
| gamma-aminobutyric acid transmembrane transporter activity | Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| gamma-aminobutyric acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). |
| monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| neurotransmitter binding | Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| taurine transmembrane transporter activity | Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. |
| taurine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| creatine transmembrane transport | The directed movement of creatine across a membrane. |
| gamma-aminobutyric acid import | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. |
| monocarboxylic acid transport | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| nitrogen compound transport | The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of necrotic cell death | Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| taurine transport | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENRASGTTS | NGETKPVCPA | MEKVEEDGTL | EREHWNNKME | FVLSVAGEII | GLGNVWRFPY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCYKNGGGAF | FIPYLIFLFT | CGIPVFFLET | ALGQYTNQGG | ITAWRRICPI | FEGIGYASQM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IVSLLNVYYI | VVLAWALFYL | FSSFTTDLPW | GSCSHEWNTE | NCVEFQKAND | SMNVTSENAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPVIEFWERR | VLKLSDGIQH | LGSLRWELVL | CLLLAWIICY | FCIWKGVKST | GKVVYFTATF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYLMLVVLLI | RGVTLPGAAQ | GIQFYLYPNI | TRLWDPQVWM | DAGTQIFFSF | AICLGCLTAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSYNKYHNNC | YRDCIALCIL | NSSTSFMAGF | AIFSILGFMS | QEQGVPISEV | AESGPGLAFI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AYPRAVVMLP | FSPLWACCFF | FMVVLLGLDS | QFVCVESLVT | ALVDMYPRVF | RKKNRREVLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LIVSVISFFI | GLIMLTEGGM | YVFQLFDYYA | ASGMCLLFVA | IFESLCVAWV | YGAGRFYDNI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EDMIGYKPWP | LIKYCWLFFT | PAVCLATFLF | SLIKYTPLTY | NKKYTYPWWG | DALGWLLALS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SMICIPAWSI | YKLRTLKGPL | RERLRQLVCP | AEDLPQKNQP | EPTAPATPMT | SLLRLTELES |
| NC |