Q9JMA9
PR
Gene name |
Slc6a14 |
Protein name |
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) |
Names |
Amino acid transporter ATB0+, Colonic system B0+ amino acid transporter CATB0+, Solute carrier family 6 member 14 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56774 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JMA9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JMA9-F1 | Predicted | AlphaFoldDB |
23 variants for Q9JMA9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409974732 | 134 | V>F | No | EVA | |
| rs3409383071 | 153 | W>R | No | EVA | |
| rs3409974692 | 153 | W>S | No | EVA | |
| rs265020879 | 155 | N>H | No | EVA | |
| rs3389522978 | 195 | T>S | No | EVA | |
| rs3408603756 | 231 | V>L | No | EVA | |
| rs3389522993 | 240 | L>F | No | EVA | |
| rs3409723887 | 243 | W>* | No | EVA | |
| rs3389554251 | 260 | V>M | No | EVA | |
| rs3409723900 | 328 | A>T | No | EVA | |
| rs3408683407 | 348 | L>* | No | EVA | |
| rs3389571137 | 355 | V>E | No | EVA | |
| rs3409383074 | 438 | A>V | No | EVA | |
| rs3409048193 | 440 | K>N | No | EVA | |
| rs3409729992 | 441 | R>L | No | EVA | |
| rs3410096944 | 443 | R>T | No | EVA | |
| rs1135283176 | 478 | A>P | No | EVA | |
| rs3389548256 | 499 | G>E | No | EVA | |
| rs3389551633 | 545 | H>L | No | EVA | |
| rs3389555669 | 566 | I>T | No | EVA | |
| rs3389551663 | 573 | I>T | No | EVA | |
| rs3409974686 | 587 | N>K | No | EVA | |
| rs236853636 | 599 | A>T | No | EVA |
No associated diseases with Q9JMA9
1 regional properties for Q9JMA9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B0AT3, solute-binding domain | 16 - 591 | IPR042701 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| (R)-carnitine transmembrane transporter activity | Enables the transfer of (R)-carnitine from one side of a membrane to the other. |
| alanine transmembrane transporter activity | Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. |
| amine transmembrane transporter activity | Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. |
| beta-alanine transmembrane transporter activity | Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid. |
| neutral, basic amino acid:sodium:chloride symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| (R)-carnitine transmembrane transport | The process in which (R)-carnitine is transported across a membrane. |
| alanine transport | The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| beta-alanine transport | The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRLKCPNFF | KCRQKEKVTA | SSENFHVGEN | DENQERGNWS | KKSDYLLSMV | GYAVGLGNVW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFPYLTYTNG | GGAFLIPYAI | MLALAGLPLF | FLECSLGQFA | SLGPVSVWRI | LPLFQGVGIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MVLISVFVAI | YYNVIIAYSL | YYLFASFQSV | LPWANCSSWA | DENCSRTPIV | TGCNVSIGAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EMFMNISWVN | TNNLTCLNGS | EVFRPGQLPS | EQYWDKVTLQ | RSSGMDETGV | VVWYLALCLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAWLIVGAAL | FKGIKSSGKV | VYFTALFPYV | VLLILLIRGA | TLEGASKGIS | YYIGAQSNFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLREAEVWKD | AATQIFYSLS | VAWGGLVALS | SYNKFNNNCY | SDAIIVCLTN | CLTSVFAGFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IFSILGHMAH | ISGKEVSQVV | KSGFDLAFIA | YPEALAQLPA | GPFWSILFFF | MLLTLGLDSQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FASIETITTT | FQDLFPKAMK | RMRVPITLGC | CLILFLLGLL | CVTQAGIYWV | HLIDHFCAGW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GILIAAILEI | AGIIWIYGGN | RFIEDIEMMI | GAKRWIFWLW | WRACWFVITP | ILLSAILVWS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVKFHRPDYA | DIPYPDWGVA | LGWCMIIFCI | IWIPIMAIIK | IVQAEGNILQ | RIISCCRPAS |
| 610 | 620 | 630 | |||
| NWGPYLEKHR | GERYRDMAEP | AKETDHEIPT | ISGSTKPE |