P28570
PR
Gene name |
Slc6a8 |
Protein name |
Sodium- and chloride-dependent creatine transporter 1 |
Names |
CHOT1, CT1, Creatine transporter 1, Solute carrier family 6 member 8 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:50690 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P28570
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P28570-F1 | Predicted | AlphaFoldDB |
No variants for P28570
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P28570 | |||||
No associated diseases with P28570
No regional properties for P28570
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P28570 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| choline transmembrane transporter activity | Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. |
| creatine transmembrane transporter activity | Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. |
| creatine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| creatine transmembrane transport | The directed movement of creatine across a membrane. |
| embryonic brain development | The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| nitrogen compound transport | The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| Q62687 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKKSAENGI | YSVSGDEKKG | PLIVSGPDGA | PSKGDGPAGL | GAPSSRLAVP | PRETWTRQMD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIMSCVGFAV | GLGNVWRFPY | LCYKNGGGVF | LIPYVLIALV | GGIPIFFLEI | SLGQFMKAGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INVWNICPLF | KGLGYASMVI | VFYCNTYYIM | VLAWGFYYLV | KSFTTTLPWA | TCGHTWNTPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVEIFRHEDC | ANASLANLTC | DQLADRRSPV | IEFWENKVLR | LSTGLEVPGA | LNWEVTLCLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ACWVLVYFCV | WKGVKSTGKI | VYFTATFPYV | VLVVLLVRGV | LLPGALDGII | YYLKPDWSKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSPQVWIDAG | TQIFFSYAIG | LGALTALGSY | NRFNNNCYKD | AIILALINSG | TSFFAGFVVF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SILGFMATEQ | GVHISKVAES | GPGLAFIAYP | RAVTLMPVAP | LWAALFFFML | LLLGLDSQFV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GVEGFITGLL | DLLPASYYFR | FQREISVALC | CALCFVIDLS | MVTDGGMYVF | QLFDYYSASG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TTLLWQAFWE | CVVVAWVYGA | DRFMDDIACM | IGYRPCPWMK | WCWSFFTPLV | CMGIFIFNVV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YYKPLVYNNT | YVYPWWGEAM | GWAFALSSML | CVPLHLLGCL | LRAKGTMAER | WQHLTQPIWG |
| 610 | 620 | 630 | |||
| LHHLEYRAQD | ADVRGLTTLT | PVSESSKVVV | VESVM |