O18875
PR
Gene name |
SLC6A8 |
Protein name |
Sodium- and chloride-dependent creatine transporter 1 |
Names |
Allergen Dog 1, Allergen Dog 2, CT1, Creatine transporter 1, Solute carrier family 6 member 8 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282367 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O18875
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O18875-F1 | Predicted | AlphaFoldDB |
171 variants for O18875
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs450160437 | 93 | P>T | No | EVA | |
| rs470214700 | 94 | Y>C | No | EVA | |
| rs477400656 | 107 | F>I | No | EVA | |
| rs445097827 | 109 | E>A | No | EVA | |
| rs465238283 | 110 | I>F | No | EVA | |
| rs434303249 | 135 | Y>* | No | EVA | |
| rs465605779 | 135 | Y>N | No | EVA | |
| rs475307263 | 148 | Y>* | No | EVA | |
| rs437471668 | 149 | I>T | No | EVA | |
| rs471170964 | 152 | L>R | No | EVA | |
| rs439774191 | 154 | W>L | No | EVA | |
| rs453383468 | 160 | V>G | No | EVA | |
| rs473415613 | 164 | T>A | No | EVA | |
| rs442005881 | 164 | T>N | No | EVA | |
| rs442005881 | 164 | T>S | No | EVA | |
| rs481387421 | 166 | T>P | No | EVA | |
| rs443492229 | 172 | C>G | No | EVA | |
| rs443492229 | 172 | C>S | No | EVA | |
| rs463604654 | 172 | C>W | No | EVA | |
| rs476965634 | 174 | H>Q | No | EVA | |
| rs445710867 | 175 | T>P | No | EVA | |
| rs479230663 | 177 | N>I | No | EVA | |
| rs448102328 | 178 | T>A | No | EVA | |
| rs448102328 | 178 | T>P | No | EVA | |
| rs437542365 | 179 | P>R | No | EVA | |
| rs457556902 | 181 | C>Y | No | EVA | |
| rs433328165 | 183 | E>A | No | EVA | |
| rs464776706 | 183 | E>Q | No | EVA | |
| rs453445734 | 184 | I>V | No | EVA | |
| rs442120453 | 188 | E>A | No | EVA | |
| rs455763484 | 188 | E>D | No | EVA | |
| rs475796864 | 189 | D>E | No | EVA | |
| rs443520036 | 192 | N>T | No | EVA | |
| rs463571436 | 194 | T>P | No | EVA | |
| rs459370952 | 197 | N>S | No | EVA | |
| rs479345115 | 200 | C>* | No | EVA | |
| rs448084604 | 201 | D>A | No | EVA | |
| rs468235405 | 202 | Q>H | No | EVA | |
| rs451203464 | 205 | D>A | No | EVA | |
| rs481835502 | 205 | D>Y | No | EVA | |
| rs464825534 | 206 | R>P | No | EVA | |
| rs433442441 | 208 | S>P | No | EVA | |
| rs453556849 | 209 | P>T | No | EVA | |
| rs435722850 | 212 | E>Q | No | EVA | |
| rs455711398 | 215 | E>V | No | EVA | |
| rs208108878 | 223 | E>G | No | EVA | |
| rs135144853 | 241 | T>A | No | EVA | |
| rs435519383 | 289 | I>F | No | EVA | |
| rs455581409 | 298 | S>T | No | EVA | |
| rs469154826 | 299 | K>N | No | EVA | |
| rs437767651 | 300 | L>P | No | EVA | |
| rs451435164 | 302 | S>Y | No | EVA | |
| rs469268255 | 309 | A>V | No | EVA | |
| rs445084793 | 321 | L>F | No | EVA | |
| rs465162452 | 323 | A>G | No | EVA | |
| rs453750568 | 324 | L>P | No | EVA | |
| rs473807973 | 325 | T>P | No | EVA | |
| rs456794768 | 326 | A>P | No | EVA | |
| rs476743103 | 327 | L>P | No | EVA | |
| rs476743103 | 327 | L>R | No | EVA | |
| rs459020842 | 328 | G>D | No | EVA | |
| rs441293502 | 329 | S>G | No | EVA | |
| rs461424498 | 330 | Y>D | No | EVA | |
| rs461424498 | 330 | Y>H | No | EVA | |
| rs481492477 | 331 | N>H | No | EVA | |
| rs450099579 | 331 | N>K | No | EVA | |
| rs463698278 | 332 | R>P | No | EVA | |
| rs482963989 | 333 | F>L | No | EVA | |
| rs482963989 | 333 | F>V | No | EVA | |
| rs445146201 | 334 | N>H | No | EVA | |
| rs465172956 | 334 | N>K | No | EVA | |
| rs445146201 | 334 | N>Y | No | EVA | |
| rs433719087 | 335 | N>K | No | EVA | |
| rs447318518 | 336 | N>K | No | EVA | |
| rs467458566 | 337 | C>R | No | EVA | |
| rs436071677 | 337 | C>W | No | EVA | |
| rs456157980 | 338 | Y>* | No | EVA | |
| rs475201067 | 344 | L>I | No | EVA | |
| rs443728162 | 347 | I>L | No | EVA | |
| rs457382524 | 352 | S>C | No | EVA | |
| rs471009027 | 356 | G>V | No | EVA | |
| rs439600076 | 360 | F>Y | No | EVA | |
| rs459725775 | 363 | L>P | No | EVA | |
| rs478985712 | 368 | T>P | No | EVA | |
| rs441081599 | 369 | E>D | No | EVA | |
| rs461159952 | 371 | G>V | No | EVA | |
| rs481227638 | 373 | H>P | No | EVA | |
| rs449712404 | 373 | H>Q | No | EVA | |
| rs469672290 | 375 | S>P | No | EVA | |
| rs476892001 | 376 | K>* | No | EVA | |
| rs445631465 | 377 | V>E | No | EVA | |
| rs455104739 | 378 | A>E | No | EVA | |
| rs435116226 | 378 | A>P | No | EVA | |
| rs437354947 | 379 | E>K | No | EVA | |
| rs457446171 | 380 | S>A | No | EVA | |
| rs448025061 | 383 | G>C | No | EVA | |
| rs461737578 | 397 | P>A | No | EVA | |
| rs482563194 | 398 | V>G | No | EVA | |
| rs464762035 | 403 | A>G | No | EVA | |
| rs446952324 | 408 | F>L | No | EVA | |
| rs435661612 | 416 | D>A | No | EVA | |
| rs455700779 | 416 | D>E | No | EVA | |
| rs435661612 | 416 | D>G | No | EVA | |
| rs467068867 | 416 | D>N | No | EVA | |
| rs467068867 | 416 | D>Y | No | EVA | |
| rs437068136 | 417 | S>R | No | EVA | |
| rs475598719 | 417 | S>R | No | EVA | |
| rs457028477 | 418 | Q>K | No | EVA | |
| rs482912226 | 423 | E>V | No | EVA | |
| rs445230923 | 425 | F>C | No | EVA | |
| rs465196961 | 426 | I>L | No | EVA | |
| rs466748743 | 429 | L>F | No | EVA | |
| rs435337327 | 430 | L>R | No | EVA | |
| rs475526579 | 431 | D>A | No | EVA | |
| rs437693715 | 431 | D>E | No | EVA | |
| rs475526579 | 431 | D>G | No | EVA | |
| rs455511360 | 431 | D>H | No | EVA | |
| rs471364049 | 435 | A>T | No | EVA | |
| rs460822931 | 436 | S>C | No | EVA | |
| rs440695426 | 436 | S>P | No | EVA | |
| rs474423991 | 440 | R>Q | No | EVA | |
| rs462965582 | 441 | F>I | No | EVA | |
| rs445292638 | 452 | T>I | No | EVA | |
| rs482975655 | 452 | T>P | No | EVA | |
| rs479010416 | 454 | C>R | No | EVA | |
| rs446719542 | 457 | I>L | No | EVA | |
| rs466922318 | 458 | D>A | No | EVA | |
| rs435456419 | 460 | S>T | No | EVA | |
| rs449145431 | 462 | V>G | No | EVA | |
| rs469161204 | 463 | T>S | No | EVA | |
| rs456628146 | 467 | M>V | No | EVA | |
| rs476634088 | 468 | Y>D | No | EVA | |
| rs438994630 | 474 | D>A | No | EVA | |
| rs438994630 | 474 | D>G | No | EVA | |
| rs452596373 | 482 | T>P | No | EVA | |
| rs441279225 | 497 | V>E | No | EVA | |
| rs472734831 | 510 | M>L | No | EVA | |
| rs522165068 | 512 | G>R | No | EVA | |
| rs475401879 | 514 | R>Q | No | EVA | |
| rs454914800 | 516 | C>G | No | EVA | |
| rs475015965 | 517 | P>A | No | EVA | |
| rs443678003 | 520 | K>R | No | EVA | |
| rs463731650 | 522 | C>S | No | EVA | |
| rs482964013 | 523 | W>G | No | EVA | |
| rs444037677 | 531 | C>S | No | EVA | |
| rs461241330 | 535 | F>S | No | EVA | |
| rs480961624 | 541 | Y>C | No | EVA | |
| rs449649983 | 551 | Y>C | No | EVA | |
| rs446339672 | 554 | P>S | No | EVA | |
| rs435053198 | 555 | W>C | No | EVA | |
| rs466460041 | 555 | W>R | No | EVA | |
| rs448748007 | 574 | L>I | No | EVA | |
| rs468760853 | 575 | H>P | No | EVA | |
| rs457382737 | 578 | G>A | No | EVA | |
| rs437304520 | 578 | G>R | No | EVA | |
| rs471008884 | 579 | C>R | No | EVA | |
| rs433144211 | 581 | L>P | No | EVA | |
| rs472524194 | 584 | K>* | No | EVA | |
| rs441081234 | 584 | K>R | No | EVA | |
| rs474560576 | 586 | T>A | No | EVA | |
| rs443305204 | 587 | M>L | No | EVA | |
| rs463251362 | 588 | A>S | No | EVA | |
| rs477123490 | 589 | E>Q | No | EVA | |
| rs445619255 | 589 | E>V | No | EVA | |
| rs444701404 | 609 | Q>* | No | EVA | |
| rs458286506 | 610 | D>H | No | EVA | |
| rs478419862 | 616 | L>R | No | EVA | |
| rs446926233 | 618 | T>P | No | EVA | |
| rs460684620 | 624 | E>D | No | EVA | |
| rs480506565 | 628 | V>E | No | EVA | |
| rs449238701 | 630 | V>G | No | EVA |
No associated diseases with O18875
No regional properties for O18875
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O18875 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| creatine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| creatine transmembrane transport | The directed movement of creatine across a membrane. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XS59 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| P51143 | SLC6A2 | Sodium-dependent noradrenaline transporter | Bos taurus (Bovine) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANKSTENGI | YSVSGEEKKG | PLIAPGPDGA | PAKGDGPAAL | GAPGSLLAVP | PRETWTRQMD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIMSCVGFAV | GLGNVWRFPY | LCYKNGGGVF | LIPYILIALI | GGIPIFFLEI | SLGQFMKAGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INVWNICPLF | KGLGYASMVI | VFYCNTYYIM | VLAWGFYYLV | KSFTTTLPWA | TCGHTWNTPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVEIFRHEDC | ANATMANLTC | DQLADRRSPV | IEFWENKVLR | LSEGLEVPGA | LNWEVTLCLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TCWVLVYFCV | WKGVKSTGKI | VYFTATFPYV | VLVVLLVRGV | LLPGALDGII | YYLKPDWSKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASPQVWIDAG | TQIFFSYAIG | LGALTALGSY | NRFNNNCYKD | AIILALINSG | TSFFAGFVVF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SILGFMATEQ | GVHISKVAES | GPGLAFIAYP | RAVTLMPVAP | LWAALFFFML | LLLGLDSQFV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GVEGFITGLL | DLLPASYYFR | FQREISVALC | CTICFVIDLS | MVTDGGMYVF | QLFDYYSASG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TTLLWQAFWE | CVVVAWVYGA | DRFMDDVACM | IGYRPCPWMK | WCWSFFTPLV | CMGIFIFNVV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YHEPLVYNNT | YVYPWWGEAV | GWAFALSSML | CVPLHLLGCL | LRAKGTMAER | WQHLTQPIWG |
| 610 | 620 | 630 | |||
| LHHLEYRAQD | SDVRGLTTLT | PVSESSKVVV | VESVM |