Q9XS59
PR
Gene name |
SLC6A15 (B0AT2, NTT73) |
Protein name |
Sodium-dependent neutral amino acid transporter B(0)AT2 |
Names |
Sodium- and chloride-dependent neurotransmitter transporter NTT73, Solute carrier family 6 member 15, Transporter v7-3 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281952 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XS59
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XS59-F1 | Predicted | AlphaFoldDB |
107 variants for Q9XS59
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs444270209 | 7 | V>G | No | EVA | |
| rs482203481 | 32 | D>A | No | EVA | |
| rs474589420 | 61 | R>I | No | EVA | |
| rs462034382 | 86 | R>G | No | EVA | |
| rs441811360 | 89 | Y>F | No | EVA | |
| rs441811360 | 89 | Y>S | No | EVA | |
| rs439780196 | 94 | N>K | No | EVA | |
| rs520934212 | 95 | G>R | No | EVA | |
| rs470013301 | 98 | A>G | No | EVA | |
| rs450142341 | 99 | Y>S | No | EVA | |
| rs461295605 | 100 | L>H | No | EVA | |
| rs481607177 | 100 | L>I | No | EVA | |
| rs441139686 | 104 | L>V | No | EVA | |
| rs459041192 | 108 | L>P | No | EVA | |
| rs459041192 | 108 | L>R | No | EVA | |
| rs439132210 | 110 | I>V | No | EVA | |
| rs456712554 | 115 | F>V | No | EVA | |
| rs443027677 | 121 | V>A | No | EVA | |
| rs438302073 | 134 | N>S | No | EVA | |
| rs476257164 | 151 | C>* | No | EVA | |
| rs436298309 | 154 | V>A | No | EVA | |
| rs473788895 | 157 | Y>H | No | EVA | |
| rs453746889 | 158 | Y>F | No | EVA | |
| rs453746889 | 158 | Y>S | No | EVA | |
| rs433775467 | 159 | N>H | No | EVA | |
| rs445338137 | 160 | V>A | No | EVA | |
| rs465376530 | 160 | V>L | No | EVA | |
| rs469452542 | 161 | I>N | No | EVA | |
| rs448264817 | 165 | S>G | No | EVA | |
| rs480946557 | 165 | S>R | No | EVA | |
| rs436214424 | 168 | Y>F | No | EVA | |
| rs447034952 | 169 | F>C | No | EVA | |
| rs478454730 | 174 | Q>L | No | EVA | |
| rs458535539 | 178 | P>A | No | EVA | |
| rs458535539 | 178 | P>T | No | EVA | |
| rs438524987 | 179 | W>L | No | EVA | |
| rs482682746 | 181 | Q>H | No | EVA | |
| rs442393553 | 184 | L>* | No | EVA | |
| rs473876994 | 185 | V>M | No | EVA | |
| rs453885681 | 186 | K>E | No | EVA | |
| rs798738382 | 190 | H>D | No | EVA | |
| rs134826380 | 235 | A>S | No | EVA | |
| rs452314413 | 296 | P>Q | No | EVA | |
| rs472264395 | 302 | A>D | No | EVA | |
| rs438710114 | 322 | S>I | No | EVA | |
| rs135798331 | 329 | N>H | No | EVA | |
| rs137170155 | 329 | N>T | No | EVA | |
| rs381244523 | 354 | A>V | No | EVA | |
| rs476198108 | 368 | I>V | No | EVA | |
| rs714581494 | 372 | S>L | No | EVA | |
| rs433971146 | 397 | A>G | No | EVA | |
| rs454247916 | 397 | A>S | No | EVA | |
| rs465402092 | 399 | T>P | No | EVA | |
| rs1114910970 | 428 | I>V | No | EVA | |
| rs469699602 | 429 | E>D | No | EVA | |
| rs449456073 | 430 | D>E | No | EVA | |
| rs480827812 | 433 | N>H | No | EVA | |
| rs458601651 | 435 | A>S | No | EVA | |
| rs478043200 | 439 | T>A | No | EVA | |
| rs482434947 | 442 | A>D | No | EVA | |
| rs797139263 | 478 | T>I | No | EVA | |
| rs460317057 | 498 | T>P | No | EVA | |
| rs446750306 | 521 | V>G | No | EVA | |
| rs461476685 | 553 | F>L | No | EVA | |
| rs473031057 | 559 | D>A | No | EVA | |
| rs432735760 | 560 | M>R | No | EVA | |
| rs452995437 | 560 | M>V | No | EVA | |
| rs457206774 | 570 | Y>* | No | EVA | |
| rs437059415 | 571 | Y>* | No | EVA | |
| rs468519560 | 572 | M>L | No | EVA | |
| rs448138205 | 575 | Y>N | No | EVA | |
| rs434588655 | 580 | M>R | No | EVA | |
| rs721710241 | 586 | I>V | No | EVA | |
| rs446172240 | 588 | S>T | No | EVA | |
| rs477184408 | 590 | V>A | No | EVA | |
| rs463618044 | 591 | N>D | No | EVA | |
| rs450012950 | 606 | K>Q | No | EVA | |
| rs440434742 | 611 | F>L | No | EVA | |
| rs445418075 | 612 | L>V | No | EVA | |
| rs483239589 | 613 | S>R | No | EVA | |
| rs443371470 | 614 | Y>* | No | EVA | |
| rs463445624 | 614 | Y>F | No | EVA | |
| rs463445624 | 614 | Y>S | No | EVA | |
| rs378221265 | 616 | T>M | No | EVA | |
| rs722716917 | 616 | T>P | No | EVA | |
| rs461485885 | 620 | V>A | No | EVA | |
| rs472486641 | 624 | S>Y | No | EVA | |
| rs452301924 | 625 | L>V | No | EVA | |
| rs438554261 | 629 | A>V | No | EVA | |
| rs476263812 | 631 | L>M | No | EVA | |
| rs456453762 | 631 | L>W | No | EVA | |
| rs467859624 | 634 | P>T | No | EVA | |
| rs454053222 | 638 | I>L | No | EVA | |
| rs465653374 | 641 | R>L | No | EVA | |
| rs438183396 | 647 | D>V | No | EVA | |
| rs469610173 | 652 | L>S | No | EVA | |
| rs449408756 | 653 | A>V | No | EVA | |
| rs481128040 | 674 | A>E | No | EVA | |
| rs478689535 | 675 | S>I | No | EVA | |
| rs447198105 | 675 | S>R | No | EVA | |
| rs458675452 | 680 | K>* | No | EVA | |
| rs442893020 | 691 | G>C | No | EVA | |
| rs442615709 | 706 | T>P | No | EVA | |
| rs474284347 | 707 | A>D | No | EVA | |
| rs471819605 | 708 | P>L | No | EVA | |
| rs433967952 | 708 | P>T | No | EVA | |
| rs475378288 | 716 | Y>D | No | EVA |
No associated diseases with Q9XS59
1 regional properties for Q9XS59
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B(0)AT2, solute-binding domain | 61 - 640 | IPR042934 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| branched-chain amino acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). |
| neutral amino acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in). |
| proline:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| leucine transport | The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| neutral amino acid transport | The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| proline transport | The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| P51143 | SLC6A2 | Sodium-dependent noradrenaline transporter | Bos taurus (Bovine) | PR |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens (Human) | PR |
| Q9GZN6 | SLC6A16 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 | Homo sapiens (Human) | PR |
| Q9H1V8 | SLC6A17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Homo sapiens (Human) | PR |
| Q9H2J7 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Homo sapiens (Human) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| Q62687 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPKNSKVVKR | ELDDEVIESV | KDLLSNEDSA | DDAFKKSELI | VDVPEEKDTD | VVERSEVKDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RPAWNSKLQY | ILAQVGFSVG | LGNVWRFPYL | CQKNGGGAYL | LPYLILLLVI | GIPLFFLELS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGQRIRRGSI | GVWNYISPQL | GGIGFASCVV | CFFVALYYNV | IIGWSLFYFS | QSFQQPLPWD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QCPLVKNASH | TFVEPECEKS | SATTYYWYRE | ALNISTSISE | SGGLNWKMTI | CLLAAWVVVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAMIKGIQSS | GKIMYFSSLF | PYVVLICFLI | RALLLNGSVD | GIRHMFTPEL | EIMLEPKVWR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAAAQVFFAL | GLGFGGVIAF | SSYNKRDNNC | HFDAVLVSFI | NFFTSILATL | VVFAVLGFKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVINEKCIAE | NSEMIIKLVK | MGNISQDIIP | HHINFSAITA | EDYDLIYDII | QKVKEEEFPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LHLNACQIED | ELNKAVQGTG | LAFIAFTEAM | THFPASPFWS | VMFFLMLVNL | GLGSMFGTIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GIITPVVDTF | KVRKEILTVI | CCLLAFCIGL | IFVQRSGNYF | VTMFDDYSAT | LPLLIVVILE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NIAVSFVYGI | DKFMEDLKDM | LGFTPNRYYY | YMWKYISPLM | LLSLLIASIV | NMGLSPPGYN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AWMEDKASEK | FLSYPTWGMV | ICISLMVLAI | LPIPVVFIIR | RCNLIDDSSG | NLASVTYKRG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RVLKEPVNLE | GDDASLIHGK | ISSEMSSPNF | GKNIYRKQSG | SPTLDTAPNG | RYGIGYLMAD |
| MPDMPESDL |