O55192
PR
Gene name |
Slc6a2 |
Protein name |
Sodium-dependent noradrenaline transporter |
Names |
Norepinephrine transporter, NET, Solute carrier family 6 member 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20538 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O55192
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O55192-F1 | Predicted | AlphaFoldDB |
26 variants for O55192
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3399520892 | 22 | E>Q | No | EVA | |
| rs235983199 | 51 | S>G | No | EVA | |
| rs3399451309 | 52 | D>V | No | EVA | |
| rs3399451356 | 55 | P>S | No | EVA | |
| rs3399463858 | 56 | R>W | No | EVA | |
| rs3389001859 | 160 | L>H | No | EVA | |
| rs3399551479 | 176 | C>W* | No | EVA | |
| rs3389001879 | 199 | H>L | No | EVA | |
| rs3389001652 | 394 | A>T | No | EVA | |
| rs3389001678 | 403 | F>L | No | EVA | |
| rs3389006267 | 404 | W>* | No | EVA | |
| rs3389001391 | 413 | L>M | No | EVA | |
| rs3389006248 | 423 | G>D | No | EVA | |
| rs3388987963 | 448 | V>A | No | EVA | |
| rs3388998862 | 451 | I>N | No | EVA | |
| rs3388987927 | 458 | L>F | No | EVA | |
| rs3388988000 | 495 | F>C | No | EVA | |
| rs3388951405 | 499 | D>G | No | EVA | |
| rs3389001355 | 537 | I>N | No | EVA | |
| rs3399492247 | 559 | W>R | No | EVA | |
| rs3389001387 | 576 | K>N | No | EVA | |
| rs3388997581 | 587 | R>K | No | EVA | |
| rs3389001432 | 593 | T>N | No | EVA | |
| rs3398537937 | 594 | P>Q | No | EVA | |
| rs3389001333 | 597 | E>D | No | EVA | |
| rs3389006235 | 615 | L>M | No | EVA |
No associated diseases with O55192
9 regional properties for O55192
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 201 - 250 | IPR001680-1 |
| repeat | WD40 repeat | 252 - 424 | IPR001680-2 |
| repeat | WD40 repeat | 426 - 468 | IPR001680-3 |
| repeat | WD40 repeat | 471 - 511 | IPR001680-4 |
| domain | LIS1 homology motif | 6 - 38 | IPR006594 |
| domain | CTLH, C-terminal LisH motif | 40 - 92 | IPR006595 |
| repeat | G-protein beta WD-40 repeat | 228 - 242 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 278 - 292 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 362 - 376 | IPR020472-3 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| alpha-tubulin binding | Binding to the microtubule constituent protein alpha-tubulin. |
| beta-tubulin binding | Binding to the microtubule constituent protein beta-tubulin. |
| dopamine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). |
| metal ion binding | Binding to a metal ion. |
| monoamine transmembrane transporter activity | Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. |
| neurotransmitter transmembrane transporter activity | Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| neurotransmitter:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). |
| norepinephrine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| dopamine uptake involved in synaptic transmission | The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| monoamine transport | The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| neurotransmitter reuptake | The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| norepinephrine transport | The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| norepinephrine uptake | The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| response to pain | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XS59 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Bos taurus (Bovine) | PR |
| P51143 | SLC6A2 | Sodium-dependent noradrenaline transporter | Bos taurus (Bovine) | PR |
| Q9H2J7 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Homo sapiens (Human) | PR |
| Q9H1V8 | SLC6A17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Homo sapiens (Human) | PR |
| Q9GZN6 | SLC6A16 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 | Homo sapiens (Human) | PR |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens (Human) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| Q62687 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLARMNPQV | QPELGGADPL | PEQPLRPCKT | ADLLVVKERN | GVQCLLASQD | SDAQPRETWG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKIDFLLSVV | GFAVDLANVW | RFPYLCYKNG | GGAFLIPYTL | FLIIAGMPLF | YMELALGQYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REGAATVWKI | CPFFKGVGYA | VILIALYVGF | YYNVIIAWSL | YYLFASFTLN | LPWTNCGHSW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSPNCTDPKL | LNASVLGDHT | KYSKYKFTPA | AEFYERGVLH | LHESSGIHDI | GLPQWQLLLC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LMVVIVVLYF | SLWKGVKTSG | KVVWITATLP | YFVLFVLLVH | GVTLPGASNG | INAYLHIDFY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLKEATVWID | AATQIFFSLG | AGFGVLIAFA | SYNKFDNNCY | RDALLTSTIN | CVTSFISGFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IFSILGYMAH | EHKVNIEDVA | TEGAGLVFIL | YPEAISTLSG | STFWAVLFFL | MLLALGLDSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MGGMEAVITG | LADDFQVLKR | HRKLFTCVVT | ISTFLLALFC | ITKGGIYVLT | LLDTFAAGTS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILFAVLMEAI | GVSWFYGVDR | FSNDIQQMMG | FKPGLYWRLC | WKFVSPAFLL | FVVVVSIINF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPLTYDDYTY | PPWANWVGWG | IALSSMILVP | AYVIYKFLSI | RGSLWERVAY | GITPENEHHL |
| 610 | |||||
| VAQRDVRQFQ | LRHWLAI |