Q62687
PR
Gene name |
Slc6a18 (Xtrp2) |
Protein name |
Sodium-dependent neutral amino acid transporter B(0)AT3 |
Names |
Renal osmotic stress-induced Na-Cl organic solute cotransporter, ROSIT, Sodium- and chloride-dependent transporter XTRP2, Solute carrier family 6 member 18, System B(0) neutral amino acid transporter AT3 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29323 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62687
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62687-F1 | Predicted | AlphaFoldDB |
No variants for Q62687
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62687 | |||||
No associated diseases with Q62687
11 regional properties for Q62687
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 202 - 251 | IPR001680-1 |
| repeat | WD40 repeat | 253 - 426 | IPR001680-2 |
| repeat | WD40 repeat | 428 - 470 | IPR001680-3 |
| repeat | WD40 repeat | 473 - 513 | IPR001680-4 |
| domain | LIS1 homology motif | 6 - 38 | IPR006594 |
| domain | CTLH, C-terminal LisH motif | 40 - 92 | IPR006595 |
| conserved_site | WD40 repeat, conserved site | 229 - 243 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 364 - 378 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 229 - 243 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 279 - 293 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 364 - 378 | IPR020472-3 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| neutral amino acid transmembrane transporter activity | Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid transmembrane transport | The process in which an amino acid is transported across a membrane. |
| hyperosmotic response | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51143 | SLC6A2 | Sodium-dependent noradrenaline transporter | Bos taurus (Bovine) | PR |
| Q9XS59 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Bos taurus (Bovine) | PR |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens (Human) | PR |
| Q9H2J7 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Homo sapiens (Human) | PR |
| Q9H1V8 | SLC6A17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Homo sapiens (Human) | PR |
| Q9GZN6 | SLC6A16 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 | Homo sapiens (Human) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQASGMDPL | VDIEDERPKW | DNKLQYLLSC | IGFAVGLGNI | WRFPYLCHTH | GGGAFLIPYF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IALVFEGIPL | FYIELAIGQR | LRRGSIGVWK | TISPYLGGVG | LGCFSVSFLV | SLYYNTILLW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLWFFLNSFQ | HPLPWSTCPL | DLNRTGFVQE | CQSSGTVSYF | WYRQTLNITS | DISNTGTIQW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLFLCLVACW | TTVYLCVIRG | IESTGKVIYF | TALFPYLVLT | IFLIRGLTLP | GATEGLTYLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPNMKILQNS | RVWLDAATQI | FFSLSLAFGG | HIAFASYNQP | RNNCEKDAVT | IALVNSMTSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YASITIFSIM | GFKASNDYGR | CLDRNILSLI | NEFDFPELSI | SRDEYPSVLM | YLNATQPERV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARLPLKTCHL | EDFLDKSASG | PGLAFIVFTE | AVLHMPGASV | WSVLFFGMLF | TLGLSSMFGN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MEGVITPLFD | MGILPKGVPK | ETMTGVVCFI | CFLSAICFTL | QSGSYWLEIF | DSFAASLNLI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IFAFMEVVGV | IHVYGIKRFC | DDIEWMTGRR | PSLYWQVTWR | VVSPMLLFGI | FLSYIVLLAQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSPSYKAWNP | QYEHFPSREE | KLYPGWVQVT | CVLLSFLPSL | WVPGIALAQL | LFQYRQRWKN |
| 610 | |||||
| THLESALKPQ | ESRGC |