O88575
PR
Gene name |
Slc6a20b (Slc6a20, Xt3, Xtrp3) |
Protein name |
Sodium- and chloride-dependent transporter XTRP3B |
Names |
IMINO-K, Solute carrier family 6 member 20B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22599 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88575
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88575-F1 | Predicted | AlphaFoldDB |
No variants for O88575
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O88575 | |||||
No associated diseases with O88575
No regional properties for O88575
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O88575 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| L-proline transmembrane transporter activity | Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. |
| neutral amino acid transmembrane transporter activity | Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid transport | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| glycine transport | The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-proline import across plasma membrane | The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol. |
| proline import across plasma membrane | The directed movement of proline from outside of a cell into the cytoplasmic compartment. |
| proline transport | The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51143 | SLC6A2 | Sodium-dependent noradrenaline transporter | Bos taurus (Bovine) | PR |
| Q9XS59 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Bos taurus (Bovine) | PR |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens (Human) | PR |
| Q9H2J7 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Homo sapiens (Human) | PR |
| Q9H1V8 | SLC6A17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Homo sapiens (Human) | PR |
| Q9GZN6 | SLC6A16 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 | Homo sapiens (Human) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| Q761V0 | Slc6a5 | Sodium- and chloride-dependent glycine transporter 2 | Mus musculus (Mouse) | PR |
| Q62687 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPSAHAVS | LPEDEELQPW | GGAGGPGQHP | GRPRSTECAH | PGVVEKVRPK | WDNPLQFLLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CISYAVGLGN | VWRFPYLCQM | YGGGNFLVPY | IIMLIVEGMP | LLYLELAVGQ | RMRQGSIGAW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTISPYLSGV | GIASLVVSFL | ASVYFNVINT | WALWYLFHSF | QDPLPWSVCP | LNSNHTGYDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ECEKASSTQY | FWYRKTLNIS | PSIQENGGVQ | WEPALCLTLA | WLMVYLCILR | GTESTGKVVY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FTTSLPYFVL | IIYLVRGLTL | HGATNGLAYM | FTPKIEQLAN | PKAWINAATQ | IFFSLGLGCG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GLIAFASYNE | PSNDCQKHAL | IVSVINSTTA | IFSSIVTFSI | YGFKATFNYE | NCLNKVILLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TNSFDLEDGF | LTVSNLEEVK | NYLASTYPNK | YSEVFPHIRN | CSLESELDTA | VQGTGLAFIV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YTEAIKNMEV | SQLWSVLYFF | MLLTLGMGSM | VGTGTAILTP | LTDSKIISSY | LPKEAISGLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CLLNCAIGMV | FTMEAGNYWF | DLFNDYTATL | SLLLIVLVET | IAVCYVYGLK | RFESDLRAMT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRTLSWYWKV | MWAFVSPLLI | VGLFIFYLSD | YILTGTLQYQ | AWDATQGHVV | TKDYPTYALA |
| 610 | 620 | 630 | |||
| VIGLLVASST | MCIPLVALGT | FVTRHFKIRE | QFSAA |