Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q761V0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q761V0-F1 | Predicted | AlphaFoldDB |
No variants for Q761V0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q761V0 | |||||
No associated diseases with Q761V0
No regional properties for Q761V0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q761V0 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| dense core granule | Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| glycinergic synapse | A synapse that uses glycine as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycine transmembrane transporter activity | Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. |
| glycine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). |
| metal ion binding | Binding to a metal ion. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| glycine import across plasma membrane | The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. |
| glycine transport | The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| neurotransmitter reuptake | The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. |
| neurotransmitter uptake | The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| synaptic transmission, glycinergic | The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| Q9W4C5 | NAAT1 | Sodium-dependent nutrient amino acid transporter 1 | Drosophila melanogaster (Fruit fly) | PR |
| P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Homo sapiens (Human) | PR |
| P48066 | SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (Human) | PR |
| P30531 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (Human) | PR |
| Q9NSD5 | SLC6A13 | Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (Human) | PR |
| Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Homo sapiens (Human) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| Q9Y345 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| P31648 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (Mouse) | PR |
| P31649 | Slc6a13 | Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (Mouse) | PR |
| P31650 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (Mouse) | PR |
| Q8VBW1 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Mus musculus (Mouse) | PR |
| Q9JMA9 | Slc6a14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Mus musculus (Mouse) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| P31647 | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Rat) | PR |
| P23978 | Slc6a1 | Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Rat) | PR |
| P28570 | Slc6a8 | Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Rat) | PR |
| O76689 | snf-6 | Sodium-dependent acetylcholine transporter | Caenorhabditis elegans | PR |
| G5EBN9 | snf-3 | Sodium- and chloride-dependent betaine transporter | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDCSAPKEMN | KQPANILEAA | VPGHRDSPRA | PRTSPEQDLP | AEAPAATVQP | PRVPRSASTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQTFQSADAR | ACEAQQSGVG | FCNLSSPRAQ | ATSAALRDLS | EGHSAQANPP | SGPAGAGNAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HCKIPALRGP | EEDANVSVGK | GTLEHNNTPA | VGWVNMSQST | VVLGTDGIAS | VLPGSVATTT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPEDEQGDEN | KARGNWSSKL | DFILSMVGYA | VGLGNVWRFP | YLAFQNGGGA | FLIPYLMMLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAGLPIFFLE | VSLGQFASQG | PVSVWKAIPA | LQGCGIAMLI | ISVLIAIYYN | VIICYTLFYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FASFVSVLPW | GSCNNPWNTP | ECKDKTKLLL | DSCVIGDHPK | IQIKNSTFCM | TAYPNLTMVN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FTSQTNKTFV | SGSEEYFKYF | VLKISAGIEY | PGEIRWPLAF | CLFLAWVIVY | ASLAKGIKSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GKVVYFTATF | PYVVLVILLI | RGVTLPGAGA | GIWYFITPKW | EKLTDATVWK | DAATQIFFSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAAWGGLITL | SSYNKFHNNC | YRDTLIVTCT | NSATSIFAGF | VIFSVIGFMA | NERKVNIENV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ADQGPGIAFV | VYPEALTRLP | LSPFWAIIFF | LMLLTLGLDT | MFATIETIVT | SISDEFPKYL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTHKPVFTLG | CCICFFIMGF | PMITQGGIYM | FQLVDTYAAS | YALVIIAIFE | LVGISYVYGL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QRFCEDIEMM | IGFKPNIFWK | VCWAFVTPTI | LTFILCFSFY | QWEPMTYGSY | RYPNWSMVLG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WLMLACSVIW | IPIMFVIKMY | LAPGRFIERL | KLVCSPQPDW | GPFLAQHRGE | RYKNMIDPLG |
| 790 | |||||
| TSSLGLKLPV | KDLELGTQC |