P51143
PR
Gene name |
SLC6A2 (NORADR) |
Protein name |
Sodium-dependent noradrenaline transporter |
Names |
Norepinephrine transporter, NET, Solute carrier family 6 member 2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282363 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51143
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51143-F1 | Predicted | AlphaFoldDB |
No variants for P51143
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51143 | |||||
No associated diseases with P51143
No regional properties for P51143
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P51143 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| dopamine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). |
| metal ion binding | Binding to a metal ion. |
| neurotransmitter:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). |
| norepinephrine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dopamine uptake involved in synaptic transmission | The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| norepinephrine transport | The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18875 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | Bos taurus (Bovine) | PR |
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| Q9XS59 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Bos taurus (Bovine) | PR |
| Q9H2J7 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Homo sapiens (Human) | PR |
| Q9H1V8 | SLC6A17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Homo sapiens (Human) | PR |
| Q9GZN6 | SLC6A16 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 | Homo sapiens (Human) | PR |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens (Human) | PR |
| Q9D687 | Slc6a19 | Sodium-dependent neutral amino acid transporter B(0)AT1 | Mus musculus (Mouse) | PR |
| O88576 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Mus musculus (Mouse) | PR |
| O88575 | Slc6a20b | Sodium- and chloride-dependent transporter XTRP3B | Mus musculus (Mouse) | PR |
| Q8BJI1 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Mus musculus (Mouse) | PR |
| O55192 | Slc6a2 | Sodium-dependent noradrenaline transporter | Mus musculus (Mouse) | PR |
| Q64093 | Slc6a20 | Sodium- and chloride-dependent transporter XTRP3 | Rattus norvegicus (Rat) | PR |
| Q62687 | Slc6a18 | Sodium-dependent neutral amino acid transporter B(0)AT3 | Rattus norvegicus (Rat) | PR |
| P31662 | Slc6a17 | Sodium-dependent neutral amino acid transporter SLC6A17 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLARMNPQV | QPENGGAGPG | SEQPPRKRKE | VLVVKERNGV | QCLLASRDGD | EQPRETWGKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDFLLSVVGF | AVDLANVWRF | PYLCYKNGGG | AFLIPYTLFL | IIAGMPLFYM | ELALGQYNRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAATVWKICP | FFKGVGYAVI | LIALYVGFYY | NVIIAWSLYY | LFSSFTPTLP | WTDCGHAWNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PNCTDPKLLN | SSVLGNHTKY | SKYKFTPAAE | FYERGVLHLH | ESSGIHDIGL | PQWQLLLCLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVVIVLFFSL | WKGVKTSGKV | VWITATLPYL | VLFVLLVHGI | TLPGASNGIN | AYLHIDFYRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KEATVWIDAA | TQIFFSLGAG | FGVLIAFASY | NKFDNNCYRD | ALLTSTINCV | TSFISGFAIF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SILGYMAHEH | KVNIEDVATE | GAGLVFILYP | EAISTLSGST | FWAIVFFIML | LALGIDSSMG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GMEAVITGLA | DDFQVLKRHR | KLFTFAVSFG | TFLLALFCIT | KGGIYVLTLL | DTFAAGTSIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FAVLMEAIGV | SWFYGVDRFS | NDIQQMMGFK | PGLYWRLCWK | FVSPAFLLFV | VIVSIINFKP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTYDDYIFPL | WANWVGWGIA | GSSMVLVPAY | IVYKFFSTRG | SIRERLAYGI | TPASEHHLVA |
| 610 | |||||
| QRDIRQFQLQ | HWLAI |