Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q00589
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q00589-F1 | Predicted | AlphaFoldDB |
No variants for Q00589
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q00589 | |||||
No associated diseases with Q00589
1 regional properties for Q00589
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exocyst complex subunit Exo70, C-terminal | 228 - 600 | IPR046364 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| gamma-aminobutyric acid:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). |
| taurine:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| taurine transport | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9MZ34 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Bos taurus (Bovine) | PR |
| P27799 | SLC6A12 | Sodium- and chloride-dependent betaine transporter | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P31641 | SLC6A6 | Sodium- and chloride-dependent taurine transporter | Homo sapiens (Human) | PR |
| O35316 | Slc6a6 | Sodium- and chloride-dependent taurine transporter | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATKEKLQCL | KDFHKDILKP | SPGKSPGTRP | EDEAEGKPPQ | REKWSSKIDF | VLSVAGGFVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGNVWRFPYL | CYKNGGGAFL | IPYFIFLFGG | GLPVFFLEVI | IGQYTSEGGI | TCWEKICPLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGIGYASIVI | VSLLNIYYVI | ILAWATYYLF | QSFQSELPWA | HCNHSWNTPQ | CMEDTMRKNK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLWITLSTKN | FTSPVTEFWE | RNVLSLSSGI | DDPGSLKWDL | ALCLLLVWLV | CFFCIWKGVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STGKVVYFTA | TFPFAMLLVL | LVRGLTLPGA | GAGIKFYLYP | DISRLEDPQV | WIDAGTQIFF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SYAICLGAMT | SLGSYNKYKY | NSYRDCMLLG | CLNSGTSFVS | GFAIFSILGF | MAQEQGVDIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DVAESGPGLA | FIAYPKAVTM | MPLPTFWSIL | FFIMLLLLGL | DSQFVEVEGQ | VTSLVDLYPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLRKGFRREI | FIAFMCSISY | LLGLSMVTEG | GMYVFQLFDY | YAASGVCLLW | VAFFECFVIA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WIYGSDNLYD | GIEDMIGYRP | GPWMKYSWAV | VTPVLCVGCF | IFSLVKYVPL | TYNKVYVYPT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WAIGLGWSLA | LSSMMCVPLV | MVIRLCQTEG | PFLVRLKYLL | TPREPNRWAV | EREGATPYSS |
| 610 | |||||
| RLAVNGALMK | PTHIIVETMM |