P27799

PR
Gene name
SLC6A12
Protein name
Sodium- and chloride-dependent betaine transporter
Names
Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:404013
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27799

Entry ID Method Resolution Chain Position Source
AF-P27799-F1 Predicted AlphaFoldDB

No variants for P27799

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27799

No associated diseases with P27799

No regional properties for P27799

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P27799

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • In kidney, locates in basolateral membranes of renal medulla
  • In liver, locates in hepatocytes cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

1 GO annotations of molecular function

Name Definition
gamma-aminobutyric acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).

4 GO annotations of biological process

Name Definition
gamma-aminobutyric acid transport The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
glycine betaine transport The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
neurotransmitter transport The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00589 SLC6A6 Sodium- and chloride-dependent taurine transporter Canis lupus familiaris (Dog) (Canis familiaris) PR
10 20 30 40 50 60
MDRKVAVPED GPPVVSWLPE EGEKLDQEGE DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW
70 80 90 100 110 120
RFPYLCYKNG GGAFFIPYFI FFFTCGIPVF FLEVALGQYT SQGSVTAWRK ICPLLQGIGL
130 140 150 160 170 180
ASVVIESYLN IYYIIILAWA LFYLFSSFTS ELPWTTCTNT WNTEHCMDFL NHSGARTATS
190 200 210 220 230 240
SENFTSPVME FWERRVLGIT SGIHDLGALR WELALCLLLA WLICYFCIWK GVKTTGKVVY
250 260 270 280 290 300
FTATFPYLML VILLIRGITL PGAYQGVIYY LKPDLLRLKD PQVWMDAGTQ IFFSFAICQG
310 320 330 340 350 360
CLTALGSYNK YHNNCYRDSI ALCFLNSATS FAAGFVVFSI LGFMAQEQGL PISEVAESGP
370 380 390 400 410 420
GLAFIAFPKA VTMMPLSQLW SCLFFIMLIF LGLDSQFVCV ECLVTASMDM FPSQLRKSGR
430 440 450 460 470 480
RELLILAIAV FCYLAGLFLV TEGGMYIFQL FDYYASSGIC LLFLAMFEVI CISWVYGADR
490 500 510 520 530 540
FYDNIEDMIG YRPWPLVKIS WLFLTPGLCL ATFLFSLSQY TPLKYNNIYV YPPWGYSIGW
550 560 570 580 590 600
FLALSSMICV PLFVIITLLK TRGSFKKRLR QLTTPDPSLP QPKQHLYLDG GTSQDCGPSP
610
TKEGLIVGEK ETHL