Q9SIA5
PR
Gene name |
DTX1 |
Protein name |
Protein DETOXIFICATION 1 |
Names |
AtDTX1, Multidrug and toxic compound extrusion protein 1, MATE protein 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G04040 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SIA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SIA5-F1 | Predicted | AlphaFoldDB |
42 variants for Q9SIA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05240694 | 10 | E>K | No | 1000Genomes | |
| ENSVATH01635460 | 11 | L>V | No | 1000Genomes | |
| ENSVATH05240693 | 16 | Q>E | No | 1000Genomes | |
| ENSVATH05240692 | 18 | T>S | No | 1000Genomes | |
| ENSVATH05240691 | 21 | T>A | No | 1000Genomes | |
| ENSVATH10948941 | 36 | A>T | No | 1000Genomes | |
| ENSVATH10948940 | 44 | A>S | No | 1000Genomes | |
| ENSVATH10948939 | 49 | P>L | No | 1000Genomes | |
| tmp_2_1336282_C_T | 67 | V>I | No | 1000Genomes | |
| tmp_2_1336248_C_G | 78 | G>A | No | 1000Genomes | |
| tmp_2_1336143_C_T | 84 | G>R | No | 1000Genomes | |
| ENSVATH05240679 | 116 | N>I | No | 1000Genomes | |
| tmp_2_1335943_G_T | 150 | Y>* | No | 1000Genomes | |
| tmp_2_1335939_A_T | 152 | F>I | No | 1000Genomes | |
| ENSVATH01635456 | 175 | G>A | No | 1000Genomes | |
| tmp_2_1335864_C_A | 177 | V>F | No | 1000Genomes | |
| ENSVATH05240677 | 186 | T>A | No | 1000Genomes | |
| ENSVATH01635454 | 189 | L>F | No | 1000Genomes | |
| tmp_2_1335819_C_A | 192 | V>F | No | 1000Genomes | |
| ENSVATH05240675 | 205 | G>E | No | 1000Genomes | |
| ENSVATH13936285 | 205 | G>R | No | 1000Genomes | |
| ENSVATH05240673 | 222 | V>L | No | 1000Genomes | |
| ENSVATH01635448 | 241 | V>I | No | 1000Genomes | |
| ENSVATH10948419 | 244 | D>Y | No | 1000Genomes | |
| tmp_2_1335656_A_T | 246 | V>E | No | 1000Genomes | |
| ENSVATH05240671 | 249 | I>T | No | 1000Genomes | |
| ENSVATH00205392 | 251 | Q>L | No | 1000Genomes | |
| ENSVATH05240665 | 299 | L>F | No | 1000Genomes | |
| ENSVATH10948417 | 308 | A>T | No | 1000Genomes | |
| ENSVATH01635422 | 333 | A>G | No | 1000Genomes | |
| ENSVATH05240660 | 363 | S>N | No | 1000Genomes | |
| ENSVATH13936191 | 371 | A>T | No | 1000Genomes | |
| tmp_2_1335015_C_T | 372 | D>N | No | 1000Genomes | |
| tmp_2_1334996_C_T | 378 | C>Y | No | 1000Genomes | |
| tmp_2_1334976_C_T | 385 | G>S | No | 1000Genomes | |
| tmp_2_1334964_C_A | 389 | V>F | No | 1000Genomes | |
| ENSVATH05240657 | 431 | K>R | No | 1000Genomes | |
| ENSVATH10948339 | 447 | I>T | No | 1000Genomes | |
| tmp_2_1334784_C_T | 449 | A>T | No | 1000Genomes | |
| ENSVATH01635412 | 459 | E>K | No | 1000Genomes | |
| tmp_2_1334646_T_C | 467 | R>G | No | 1000Genomes | |
| ENSVATH01635408 | 473 | N>T | No | 1000Genomes |
No associated diseases with Q9SIA5
No regional properties for Q9SIA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SIA5 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| efflux transmembrane transporter activity | Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cadmium ion transport | The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| sequestering of metal ion | The process of binding or confining metal ions such that they are separated from other components of a biological system. |
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEPFLLRDE | LLVPSQVTWH | TNPLTVELKR | VSRLAAPMAT | VTIAQYLLPV | ISVMVAGHNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELQLSGVALA | NSFTNVTGFS | IMCGLVGALE | TLCGQAYGAK | QYEKIGTYAY | SAIASNIPIC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLISILWLYI | EKILISLGQD | PEISRIAGSY | AFWLIPALFG | QAIVIPLSRF | LLTQGLVIPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFTAVTTLLF | HVLVCWTLVF | LFGLGCNGPA | MATSVSFWFY | AVILSCYVRF | SSSCEKTRGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSRDFVSSIK | QFFQYGIPSA | AMICLEWWLF | EILILCSGLL | PNPKLETSVL | SICLTIETLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YVISAGVAAA | VSTRVSNNLG | AGNPQVARVS | VLAGLCLWIV | ESAFFSILLF | TCRNIIGYAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNSKEVLDYV | ADLTPLLCLS | FILDGFTAVL | NGVARGSGWQ | HIGAWNNTVS | YYLVGAPVGI |
| 430 | 440 | 450 | 460 | 470 | |
| YLAFSRELNG | KGLWCGVVVG | STVQATILAI | VTASINWKEQ | AEKARKRIVS | TENRLA |