F4HPH1
PR
Gene name |
DTX22 |
Protein name |
Protein DETOXIFICATION 22 |
Names |
AtDTX22, Multidrug and toxic compound extrusion protein 22, MATE protein 22 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G33090 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4HPH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4HPH1-F1 | Predicted | AlphaFoldDB |
52 variants for F4HPH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04709463 | 4 | E>D | No | 1000Genomes | |
| ENSVATH04709462 | 4 | E>G | No | 1000Genomes | |
| ENSVATH14051500 | 8 | L>H | No | 1000Genomes | |
| ENSVATH12703881 | 9 | T>S | No | 1000Genomes | |
| ENSVATH01161947 | 11 | A>D | No | 1000Genomes | |
| ENSVATH01161947 | 11 | A>V | No | 1000Genomes | |
| ENSVATH01161949 | 15 | K>R | No | 1000Genomes | |
| ENSVATH01161949 | 15 | K>T | No | 1000Genomes | |
| ENSVATH14051501 | 17 | T>N | No | 1000Genomes | |
| tmp_1_11993519_G_T | 21 | G>V | No | 1000Genomes | |
| ENSVATH04709464 | 22 | E>D | No | 1000Genomes | |
| ENSVATH01161951 | 24 | N>K | No | 1000Genomes | |
| ENSVATH01161952 | 25 | D>N | No | 1000Genomes | |
| ENSVATH01161952 | 25 | D>Y | No | 1000Genomes | |
| ENSVATH01161953 | 35 | I>S | No | 1000Genomes | |
| tmp_1_11993569_A_G | 38 | K>E | No | 1000Genomes | |
| ENSVATH04709468 | 68 | I>L | No | 1000Genomes | |
| tmp_1_11994599_G_A | 133 | M>I | No | 1000Genomes | |
| ENSVATH12704134 | 140 | G>S | No | 1000Genomes | |
| ENSVATH12704195 | 147 | G>A | No | 1000Genomes | |
| ENSVATH12704196 | 150 | D>E | No | 1000Genomes | |
| ENSVATH01162001 | 150 | D>G | No | 1000Genomes | |
| ENSVATH04709499 | 150 | D>N | No | 1000Genomes | |
| ENSVATH12704197 | 151 | H>R | No | 1000Genomes | |
| ENSVATH12704199 | 155 | V>M | No | 1000Genomes | |
| ENSVATH12704200 | 162 | W>C | No | 1000Genomes | |
| tmp_1_11994750_A_G | 184 | S>G | No | 1000Genomes | |
| ENSVATH14051517 | 213 | F>I | No | 1000Genomes | |
| tmp_1_11994857_G_A | 219 | M>I | No | 1000Genomes | |
| ENSVATH00061068 | 225 | A>T | No | 1000Genomes | |
| tmp_1_11994900_C_T | 234 | L>F | No | 1000Genomes | |
| ENSVATH14051518 | 251 | M>V | No | 1000Genomes | |
| tmp_1_11994973_G_T | 258 | W>L | No | 1000Genomes | |
| ENSVATH04709502 | 261 | F>L | No | 1000Genomes | |
| tmp_1_11995266_A_T | 275 | L>F | No | 1000Genomes | |
| tmp_1_11995529_C_G | 308 | Q>E | No | 1000Genomes | |
| ENSVATH12704355 | 344 | F>L | No | 1000Genomes | |
| ENSVATH12704356 | 351 | L>I | No | 1000Genomes | |
| ENSVATH01162013 | 359 | F>C | No | 1000Genomes | |
| ENSVATH12704359 | 360 | L>I | No | 1000Genomes | |
| tmp_1_11995829_G_C | 363 | R>T | No | 1000Genomes | |
| tmp_1_11995891_C_T | 384 | L>F | No | 1000Genomes | |
| tmp_1_11995903_T_G | 388 | S>A | No | 1000Genomes | |
| ENSVATH04709533 | 397 | V>I | No | 1000Genomes | |
| tmp_1_11996161_A_T | 439 | K>I | No | 1000Genomes | |
| ENSVATH14051524 | 457 | T>S | No | 1000Genomes | |
| ENSVATH04709542 | 461 | L>I | No | 1000Genomes | |
| ENSVATH01162025 | 462 | R>T | No | 1000Genomes | |
| ENSVATH04709549 | 477 | N>S | No | 1000Genomes | |
| tmp_1_11996526_T_A | 490 | I>N | No | 1000Genomes | |
| ENSVATH04709550 | 491 | S>A | No | 1000Genomes | |
| ENSVATH14051597 | 492 | S>L | No | 1000Genomes |
No associated diseases with F4HPH1
4 regional properties for F4HPH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, CCCH-type | 88 - 122 | IPR000571-1 |
| domain | Zinc finger, CCCH-type | 134 - 164 | IPR000571-2 |
| conserved_site | tRNA-dihydrouridine synthase, conserved site | 378 - 396 | IPR018517 |
| domain | DUS-like, FMN-binding domain | 292 - 572 | IPR035587 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGEGGELTA | ALLKKTTENG | GEENDELGLK | EKVWIESKKL | WVVAAPSIFT | KFSTYGVSLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQGFVGHIGP | TELAAYSITF | TVLLRFSNGI | LLGMASALGT | LCGQAYGAKQ | YHMLGIHLQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SWIVLTGCTI | CIMPIFIFSG | PILLALGQED | HIVRVARVIA | LWLIAINFTF | VPAFTCQIFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSQSKNKIIA | YVSAVTLGLH | VFFSWLLVVH | FNFGITGAMT | STLVAFWMPN | IVQLLYVTSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GCKDTWRGFT | MLAFKDLWPV | FKLSLSSGGM | VCLELWYNSI | LVLLTGNLKN | AEVAIDALAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CINVNALQMM | IALGFLAAVS | VRVSNELGRG | NPEGAKFATI | VAVFTSLSIG | LVLFFVFLFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGRISYIFTT | SEAVAAEVAD | LSPLLAFSIL | LNSVQPVLSG | VAVGAGWQGY | VAYINLACYY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLGIPVGLVL | GYVVGLQVKG | VWIGMLFGIF | VQTCVLTIMT | LRTDWDQQVS | TSLKNINRWV |
| 490 | |||||
| VPESRDANQI | SSEE |