Q8W488
Gene name |
DTX21 |
Protein name |
Protein DETOXIFICATION 21 |
Names |
AtDTX21, Multidrug and toxic compound extrusion protein 21, MATE protein 21 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G33110 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W488
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W488-F1 | Predicted | AlphaFoldDB |
27 variants for Q8W488
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_12005087_G_A | 2 | A>T | No | 1000Genomes | |
| ENSVATH01162452 | 7 | E>D | No | 1000Genomes | |
| ENSVATH12706977 | 16 | T>S | No | 1000Genomes | |
| ENSVATH04709871 | 24 | K>N | No | 1000Genomes | |
| ENSVATH04709872 | 27 | L>V | No | 1000Genomes | |
| tmp_1_12005174_C_A | 31 | Q>K | No | 1000Genomes | |
| ENSVATH01162454 | 42 | I>V | No | 1000Genomes | |
| ENSVATH12706978 | 71 | I>L | No | 1000Genomes | |
| ENSVATH12706979 | 73 | L>F | No | 1000Genomes | |
| ENSVATH12706980 | 76 | Y>N | No | 1000Genomes | |
| ENSVATH12707407 | 145 | A>S | No | 1000Genomes | |
| ENSVATH12707409 | 214 | G>E | No | 1000Genomes | |
| tmp_1_12007659_T_C | 307 | L>P | No | 1000Genomes | |
| tmp_1_12007812_T_A | 329 | S>R | No | 1000Genomes | |
| ENSVATH04709924 | 329 | S>T | No | 1000Genomes | |
| ENSVATH01162514 | 342 | A>T | No | 1000Genomes | |
| tmp_1_12007879_G_A | 352 | V>I | No | 1000Genomes | |
| ENSVATH01162515 | 376 | A>D | No | 1000Genomes | |
| ENSVATH14052030 | 377 | E>K | No | 1000Genomes | |
| ENSVATH12707619 | 411 | V>L | No | 1000Genomes | |
| tmp_1_12008205_A_G | 426 | I>V | No | 1000Genomes | |
| tmp_1_12008414_T_C | 458 | V>A | No | 1000Genomes | |
| ENSVATH04709939 | 458 | V>I | No | 1000Genomes | |
| tmp_1_12008538_G_A | 469 | V>M | No | 1000Genomes | |
| ENSVATH01162528 | 485 | R>I | No | 1000Genomes | |
| ENSVATH14052032 | 490 | V>I | No | 1000Genomes | |
| tmp_1_12008613_G_C | 494 | E>Q | No | 1000Genomes |
No associated diseases with Q8W488
No regional properties for Q8W488
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8W488 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGGGGELTA | ALLKKTAENG | GEEKDELGLK | QKVWIESKKL | WIVAAPAIFT | RFSTFGVSII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SQSFIGHLGP | IELAAYSITF | TVLLRFSNGI | LLGMASALET | LCGQAYGAKQ | NHMLGIYLQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SWIVLTGCTI | CLTPVYIFSG | PILLALGQEE | RIVRVARIIA | LWVIGINFSF | VPSFTCQMFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QAQSKNKIIA | YVAAVSLGVH | VFLSWLLMVH | FNFGITGAMT | STLVAFWLPN | IAQLLFVTCG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GCKDTWRGFS | MMAFKDLWPV | FKLSMSSGGM | LCLELWYNSI | LVLLTGNLKN | AEVALDALAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLNINGLEMM | IALGFLAAAS | VRVSNELGSG | NPKGAKFATL | TAVFTSLSLG | IVLFFVFLFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGRVSYIFTT | SEAVAAEVAD | LSPLLAFSIL | MNSVQPVLSG | VAVGAGWQGY | VTYVNLACYY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVGIPIGIIL | GYVVGLQVKG | VWIGMLFGIF | VQTCVLTVMT | LRTDWDQQVS | TSLRRLNRWV |
| 490 | |||||
| VPESRDVNQV | SSEE |