F4HQ05
PR
Gene name |
DTX8 |
Protein name |
Protein DETOXIFICATION 8 |
Names |
AtDTX8, Multidrug and toxic compound extrusion protein 8, MATE protein 8 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G66780 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4HQ05
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4HQ05-F1 | Predicted | AlphaFoldDB |
63 variants for F4HQ05
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_24909222_G_A | 4 | G>S | No | 1000Genomes | |
| ENSVATH13750622 | 7 | L>F | No | 1000Genomes | |
| tmp_1_24909234_G_A | 8 | V>M | No | 1000Genomes | |
| ENSVATH01486003 | 9 | P>L | No | 1000Genomes | |
| ENSVATH05083948 | 17 | D>Y | No | 1000Genomes | |
| ENSVATH05083949 | 20 | N>T | No | 1000Genomes | |
| ENSVATH01486005 | 22 | K>T | No | 1000Genomes | |
| ENSVATH05083950 | 23 | S>Y | No | 1000Genomes | |
| ENSVATH14432671 | 33 | T>I | No | 1000Genomes | |
| ENSVATH05083953 | 34 | E>D | No | 1000Genomes | |
| ENSVATH14432672 | 36 | M>T | No | 1000Genomes | |
| tmp_1_24909405_G_A | 65 | G>S | No | 1000Genomes | |
| ENSVATH14432673 | 84 | V>A | No | 1000Genomes | |
| ENSVATH01486007 | 90 | I>L | No | 1000Genomes | |
| tmp_1_24909761_T_C | 91 | F>S | No | 1000Genomes | |
| ENSVATH00127284 | 108 | G>E | No | 1000Genomes | |
| ENSVATH00127285 | 112 | N>I | No | 1000Genomes | |
| ENSVATH00127286 | 112 | N>K | No | 1000Genomes | |
| ENSVATH05083977 | 114 | S>N | No | 1000Genomes | |
| ENSVATH01486023 | 127 | V>F | No | 1000Genomes | |
| ENSVATH13750637 | 139 | D>E | No | 1000Genomes | |
| tmp_1_24909914_T_G | 142 | L>W | No | 1000Genomes | |
| ENSVATH05083979 | 146 | H>N | No | 1000Genomes | |
| ENSVATH14432680 | 153 | Q>E | No | 1000Genomes | |
| tmp_1_24909976_A_T | 163 | I>L | No | 1000Genomes | |
| ENSVATH14432681 | 164 | P>Q | No | 1000Genomes | |
| ENSVATH05083985 | 176 | T>N | No | 1000Genomes | |
| ENSVATH01486029 | 187 | P>A | No | 1000Genomes | |
| ENSVATH00127288 | 197 | F>C | No | 1000Genomes | |
| ENSVATH01486030 | 200 | V>I | No | 1000Genomes | |
| ENSVATH01486032 | 212 | F>L | No | 1000Genomes | |
| tmp_1_24910136_G_C | 216 | G>A | No | 1000Genomes | |
| ENSVATH01486034 | 217 | A>T | No | 1000Genomes | |
| ENSVATH01486037 | 222 | G>D | No | 1000Genomes | |
| tmp_1_24910177_G_A | 230 | G>S | No | 1000Genomes | |
| ENSVATH00127291 | 234 | A>V | No | 1000Genomes | |
| tmp_1_24910207_G_A | 240 | A>T | No | 1000Genomes | |
| ENSVATH01486040 | 244 | K>E | No | 1000Genomes | |
| ENSVATH01486041 | 245 | N>K | No | 1000Genomes | |
| ENSVATH05083987 | 245 | N>S | No | 1000Genomes | |
| ENSVATH00127292 | 249 | R>G | No | 1000Genomes | |
| ENSVATH05083988 | 251 | Q>L | No | 1000Genomes | |
| tmp_1_24910249_T_G | 254 | F>V | No | 1000Genomes | |
| ENSVATH00127294 | 256 | S>G | No | 1000Genomes | |
| ENSVATH13750638 | 258 | K>T | No | 1000Genomes | |
| ENSVATH00127295 | 262 | T>A | No | 1000Genomes | |
| tmp_1_24910625_A_G | 304 | M>V | No | 1000Genomes | |
| ENSVATH14432683 | 335 | A>V | No | 1000Genomes | |
| ENSVATH01486066 | 337 | S>A | No | 1000Genomes | |
| tmp_1_24910818_G_T | 338 | A>S | No | 1000Genomes | |
| ENSVATH00127302 | 349 | D>N | No | 1000Genomes | |
| ENSVATH00127304 | 360 | Y>C | No | 1000Genomes | |
| ENSVATH05083998 | 369 | S>T | No | 1000Genomes | |
| ENSVATH14432745 | 403 | R>S | No | 1000Genomes | |
| ENSVATH13750650 | 415 | N>I | No | 1000Genomes | |
| ENSVATH09358071 | 446 | L>F | No | 1000Genomes | |
| ENSVATH05084012 | 454 | I>T | No | 1000Genomes | |
| ENSVATH13750654 | 470 | A>S | No | 1000Genomes | |
| tmp_1_24911447_G_C | 474 | D>H | No | 1000Genomes | |
| tmp_1_24911450_A_G | 475 | R>G | No | 1000Genomes | |
| tmp_1_24911468_C_T | 481 | P>S | No | 1000Genomes | |
| ENSVATH05084016 | 484 | I>S | No | 1000Genomes | |
| ENSVATH01486073 | 486 | I>L | No | 1000Genomes |
No associated diseases with F4HQ05
No regional properties for F4HQ05
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4HQ05 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENGFSLVPK | EEEEEEDYSN | EKSEDQTSYY | LSTEMMKKVS | FMAAPMVAVA | ASQYLLQVIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IVMAGHLDEL | SLSAVAIATS | LTNVTGFSLI | FGLAGALETL | CGQAFGAGQF | RNISAYTYGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MLCLLLVCFP | ISLLWVFMDK | LLELFHQDPL | ISQLACRYSI | WLIPALFGYS | VLQSMTRFFQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQGLVLPLFL | SSLGALFFHV | PFSWLLVYKL | RFGIVGAALS | IGFSYWLNVG | LLWAFMRDSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LYRKNWNLRA | QEIFLSMKQF | ITLAIPTAMM | TCLEWWSFEL | LILMSGLLPN | SKLETSVLSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLTMSSLHYV | IVNAIGAAAS | THVSNKLGAG | NPKAARSAAN | SAIFLGMIDA | AIVSISLYSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRNWAYIFSN | ESEVADYVTQ | ITPFLCLSIG | VDSFLAVLSG | VARGTGWQHI | GAYANIGSYY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVGIPVGSIL | CFVVKLRGKG | LWIGILVGST | LQTIVLALVT | FFTNWEQEVA | KARDRVIEMI |
| PQEII |