Q9FHB6
PR
Gene name |
DTX16 |
Protein name |
Protein DETOXIFICATION 16 |
Names |
AtDTX16, Multidrug and toxic compound extrusion protein 16, MATE protein 16 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G52450 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FHB6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FHB6-F1 | Predicted | AlphaFoldDB |
33 variants for Q9FHB6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07401821 | 4 | D>N | No | 1000Genomes | |
| ENSVATH07401820 | 18 | G>E | No | 1000Genomes | |
| ENSVATH07401819 | 19 | E>A | No | 1000Genomes | |
| ENSVATH12718413 | 38 | I>V | No | 1000Genomes | |
| ENSVATH12718412 | 40 | V>M | No | 1000Genomes | |
| tmp_5_21291575_C_A | 59 | G>C | No | 1000Genomes | |
| tmp_5_21291572_A_G | 60 | S>P | No | 1000Genomes | |
| ENSVATH07401791 | 87 | A>S | No | 1000Genomes | |
| tmp_5_21290731_C_T,A | 99 | K>N | No | 1000Genomes | |
| tmp_5_21290704_C_A | 108 | M>I | No | 1000Genomes | |
| tmp_5_21290703_G_A | 109 | Q>* | No | 1000Genomes | |
| tmp_5_21290681_G_A | 116 | T>I | No | 1000Genomes | |
| tmp_5_21290669_A_G | 120 | I>T | No | 1000Genomes | |
| ENSVATH12718406 | 126 | W>C | No | 1000Genomes | |
| ENSVATH07401786 | 162 | L>V | No | 1000Genomes | |
| tmp_5_21290456_A_T | 191 | V>D | No | 1000Genomes | |
| tmp_5_21290454_G_T | 192 | L>I | No | 1000Genomes | |
| ENSVATH07401778 | 222 | L>F | No | 1000Genomes | |
| ENSVATH07401775 | 243 | E>G | No | 1000Genomes | |
| tmp_5_21290289_C_T | 247 | D>N | No | 1000Genomes | |
| tmp_5_21290128_A_T | 271 | L>H | No | 1000Genomes | |
| ENSVATH07401772 | 275 | L>F | No | 1000Genomes | |
| tmp_5_21290101_G_T | 280 | P>Q | No | 1000Genomes | |
| ENSVATH07401768 | 294 | N>T | No | 1000Genomes | |
| ENSVATH14628063 | 355 | W>R | No | 1000Genomes | |
| ENSVATH14628062 | 383 | D>E | No | 1000Genomes | |
| tmp_5_21289492_C_T | 397 | G>R | No | 1000Genomes | |
| ENSVATH14628061 | 444 | V>I | No | 1000Genomes | |
| tmp_5_21289109_T_C | 465 | N>S | No | 1000Genomes | |
| ENSVATH00729329 | 468 | E>D | No | 1000Genomes | |
| ENSVATH07401756 | 469 | S>F | No | 1000Genomes | |
| ENSVATH07401754 | 480 | D>G | No | 1000Genomes | |
| ENSVATH07401753 | 486 | F>Y | No | 1000Genomes |
No associated diseases with Q9FHB6
No regional properties for Q9FHB6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9FHB6 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to nematode | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. |
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRDDRERGEG | DLSWPLIGEK | SSVKEEVKKQ | LWLSGPLIAV | SLLQFCLQVI | SVMFVGHLGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPLSAASIAT | SFASVTGFSF | LMGTASALDT | LCGQAYGAKK | YGMLGIQMQR | AMFVLTLASI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLSIIWANTE | HLLVFFGQNK | SIATLAGSYA | KFMIPSIFAY | GLLQCFNRFL | QAQNNVFPVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCSGVTTSLH | VLLCWVLVFK | SGLGFQGAAL | ANSISYWLNV | VLLFCYVKFS | PSCSLTWTGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKEALRDILP | FLRLAVPSAL | MVCLEMWSFE | LLVLLSGLLP | NPVLETSVLS | ICLNTSGTMW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MIPFGLSGAA | STRISNELGA | GNPKVAKLAV | RVVICIAVAE | SIVIGSVLIL | IRNIWGLAYS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SELEVVSYVA | SMMPILALGN | FLDSLQCVLS | GVARGCGWQK | IGAIINLGSY | YLVGVPSGLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAFHFHVGGR | GLWLGIICAL | VVQVFGLGLV | TIFTNWDEEA | KKATNRIESS | SSVKDFAVDD |
| RSVVVF |