F4I4Q3
PR
Gene name |
DTX32 |
Protein name |
Protein DETOXIFICATION 32 |
Names |
AtDTX32, Multidrug and toxic compound extrusion protein 32, MATE protein 32 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G23300 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4I4Q3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4I4Q3-F1 | Predicted | AlphaFoldDB |
71 variants for F4I4Q3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH11878271 | 18 | H>Q | No | 1000Genomes | |
| tmp_1_8265994_G_A | 19 | R>* | No | 1000Genomes | |
| tmp_1_8265924_G_A | 42 | A>V | No | 1000Genomes | |
| ENSVATH04629830 | 51 | L>P | No | 1000Genomes | |
| tmp_1_8265885_G_A | 55 | A>V | No | 1000Genomes | |
| ENSVATH04629829 | 58 | T>I | No | 1000Genomes | |
| tmp_1_8265841_G_T | 70 | Q>K | No | 1000Genomes | |
| ENSVATH11878266 | 75 | H>D | No | 1000Genomes | |
| ENSVATH11878265 | 80 | A>G | No | 1000Genomes | |
| ENSVATH01093241 | 83 | A>V | No | 1000Genomes | |
| ENSVATH04629828 | 92 | S>A | No | 1000Genomes | |
| tmp_1_8265771_C_T | 93 | G>D | No | 1000Genomes | |
| ENSVATH04629826 | 98 | I>V | No | 1000Genomes | |
| ENSVATH11878165 | 109 | L>F | No | 1000Genomes | |
| ENSVATH01093238 | 120 | E>A | No | 1000Genomes | |
| ENSVATH04629814 | 138 | L>R | No | 1000Genomes | |
| ENSVATH04629813 | 143 | F>I | No | 1000Genomes | |
| ENSVATH04629813 | 143 | F>L | No | 1000Genomes | |
| ENSVATH00039561 | 148 | T>A | No | 1000Genomes | |
| tmp_1_8265464_C_A | 159 | E>* | No | 1000Genomes | |
| tmp_1_8265449_C_G | 164 | A>P | No | 1000Genomes | |
| tmp_1_8265446_C_T | 165 | G>R | No | 1000Genomes | |
| tmp_1_8265434_G_A | 169 | L>F | No | 1000Genomes | |
| tmp_1_8265422_G_A | 173 | P>S | No | 1000Genomes | |
| ENSVATH04629810 | 175 | L>F | No | 1000Genomes | |
| ENSVATH04629803 | 214 | L>F | No | 1000Genomes | |
| ENSVATH11877966 | 221 | W>* | No | 1000Genomes | |
| tmp_1_8265148_T_C | 240 | T>A | No | 1000Genomes | |
| tmp_1_8265117_G_C | 250 | S>C | No | 1000Genomes | |
| ENSVATH04629802 | 252 | R>T | No | 1000Genomes | |
| ENSVATH00039558 | 259 | W>* | No | 1000Genomes | |
| tmp_1_8265087_A_T | 260 | M>K | No | 1000Genomes | |
| ENSVATH00039557 | 261 | A>V | No | 1000Genomes | |
| tmp_1_8264860_A_T | 306 | L>H | No | 1000Genomes | |
| ENSVATH04629797 | 309 | C>* | No | 1000Genomes | |
| ENSVATH13951981 | 309 | C>R | No | 1000Genomes | |
| ENSVATH04629795 | 325 | A>T | No | 1000Genomes | |
| tmp_1_8264734_G_C | 326 | A>G | No | 1000Genomes | |
| tmp_1_8264732_C_A | 327 | V>L | No | 1000Genomes | |
| ENSVATH00039554 | 331 | E>V | No | 1000Genomes | |
| tmp_1_8264603_T_C | 344 | K>R | No | 1000Genomes | |
| ENSVATH00039553 | 347 | L>S | No | 1000Genomes | |
| ENSVATH11877832 | 349 | V>M | No | 1000Genomes | |
| tmp_1_8264570_A_T | 355 | V>E | No | 1000Genomes | |
| tmp_1_8264546_A_G | 363 | V>A | No | 1000Genomes | |
| ENSVATH11877831 | 369 | R>Q | No | 1000Genomes | |
| tmp_1_8264523_T_C | 371 | K>E | No | 1000Genomes | |
| tmp_1_8264481_G_T | 385 | L>I | No | 1000Genomes | |
| ENSVATH11877830 | 389 | L>R | No | 1000Genomes | |
| tmp_1_8264308_A_G | 409 | V>A | No | 1000Genomes | |
| tmp_1_8264290_C_T | 415 | W>* | No | 1000Genomes | |
| tmp_1_8264282_T_G | 418 | I>L | No | 1000Genomes | |
| ENSVATH13951976 | 423 | N>Y | No | 1000Genomes | |
| ENSVATH11877828 | 425 | G>E | No | 1000Genomes | |
| ENSVATH04629788 | 427 | Y>C | No | 1000Genomes | |
| ENSVATH04629787 | 431 | G>S | No | 1000Genomes | |
| ENSVATH00039551 | 433 | P>A | No | 1000Genomes | |
| ENSVATH11877827 | 434 | I>M | No | 1000Genomes | |
| tmp_1_8264224_A_T | 437 | V>E | No | 1000Genomes | |
| ENSVATH04629786 | 442 | M>V | No | 1000Genomes | |
| ENSVATH00039549 | 449 | I>T | No | 1000Genomes | |
| tmp_1_8264056_A_C | 464 | L>R | No | 1000Genomes | |
| ENSVATH09373658 | 470 | R>S | No | 1000Genomes | |
| ENSVATH09373656 | 471 | T>N | No | 1000Genomes | |
| ENSVATH09373657 | 471 | T>S | No | 1000Genomes | |
| tmp_1_8264021_C_T | 476 | E>K | No | 1000Genomes | |
| ENSVATH04629779 | 488 | G>R | No | 1000Genomes | |
| tmp_1_8263895_T_C | 494 | R>G | No | 1000Genomes | |
| ENSVATH04629777 | 508 | N>H | No | 1000Genomes | |
| ENSVATH04629776 | 508 | N>S | No | 1000Genomes | |
| tmp_1_8263831_T_G | 515 | K>T | No | 1000Genomes |
No associated diseases with F4I4Q3
No regional properties for F4I4Q3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4I4Q3 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C994 | DTX14 | Protein DETOXIFICATION 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METLNVDHED | TISSEQEHRA | HTKSDTDMPP | ISGGRDFIRQ | FAAESKKLWW | LAGPAIFTSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CQYSLGAVTQ | ILAGHVNTLA | LAAVSIQNSV | ISGFSVGIML | GMGSALATLC | GQAYGAGQLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MMGIYLQRSW | IILNSCALLL | CLFYVFATPL | LSLLGQSPEI | SKAAGKFSLW | MIPQLFAYAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NFATAKFLQA | QSKVIAMAVI | AATVLLQHTL | LSWLLMLKLR | WGMAGGAVVL | NMSWWLIDVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QIVYICGGSS | GRAWSGLSWM | AFKNLRGFAR | LSLASAVMVC | LEVWYFMALI | LFAGYLKNPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSVAALSICM | NILGWPIMVA | FGFNAAVSVR | ESNELGAEHP | RRAKFLLIVA | MITSVSIGIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISVTLIVLRD | KYPAMFSDDE | EVRVLVKQLT | PLLALTIVIN | NIQPVLSGVA | VGAGWQGIVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVNIGCYYLC | GIPIGLVLGY | KMELGVKGIW | TGMLTGTVVQ | TSVLLFIIYR | TNWKKEASLA |
| 490 | 500 | 510 | |||
| EARIKKWGDQ | SNKREEIDLC | EEDENNSNGE | NNHRK |