Q9C994
PR
Gene name |
DTX14 |
Protein name |
Protein DETOXIFICATION 14 |
Names |
AtDTX14, Multidrug and toxic compound extrusion protein 14, MATE protein 14 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G71140 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9C994
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5Y50 | X-ray | 260 A | A | 20-473 | PDB |
| AF-Q9C994-F1 | Predicted | AlphaFoldDB |
36 variants for Q9C994
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05124696 | 17 | V>L | No | 1000Genomes | |
| ENSVATH01520358 | 25 | R>W | No | 1000Genomes | |
| tmp_1_26824841_C_T | 27 | T>M | No | 1000Genomes | |
| ENSVATH13790310 | 55 | V>A | No | 1000Genomes | |
| tmp_1_26824975_T_A | 72 | F>I | No | 1000Genomes | |
| ENSVATH13790314 | 107 | H>Q | No | 1000Genomes | |
| ENSVATH13790315 | 118 | V>L | No | 1000Genomes | |
| ENSVATH01520360 | 124 | L>V | No | 1000Genomes | |
| ENSVATH01520361 | 127 | T>R | No | 1000Genomes | |
| ENSVATH05124699 | 135 | L>F | No | 1000Genomes | |
| ENSVATH05124700 | 140 | A>S | No | 1000Genomes | |
| ENSVATH01520363 | 174 | S>Y | No | 1000Genomes | |
| ENSVATH05124701 | 181 | M>I | No | 1000Genomes | |
| ENSVATH00136992 | 189 | I>V | No | 1000Genomes | |
| ENSVATH05124702 | 191 | I>M | No | 1000Genomes | |
| tmp_1_26825426_A_C | 196 | S>R | No | 1000Genomes | |
| ENSVATH05124703 | 202 | G>S | No | 1000Genomes | |
| tmp_1_26825498_G_A | 220 | V>M | No | 1000Genomes | |
| tmp_1_26825504_G_A | 222 | V>I | No | 1000Genomes | |
| tmp_1_26825529_C_G | 230 | S>C | No | 1000Genomes | |
| ENSVATH00136995 | 234 | S>R | No | 1000Genomes | |
| ENSVATH01520366 | 239 | T>P | No | 1000Genomes | |
| ENSVATH05124704 | 256 | I>F | No | 1000Genomes | |
| ENSVATH14467527 | 309 | A>V | No | 1000Genomes | |
| tmp_1_26826041_C_T | 315 | A>V | No | 1000Genomes | |
| tmp_1_26826085_G_T | 330 | V>F | No | 1000Genomes | |
| tmp_1_26826217_C_T | 374 | P>S | No | 1000Genomes | |
| tmp_1_26826259_G_T | 388 | A>S | No | 1000Genomes | |
| tmp_1_26826447_T_G | 423 | F>L | No | 1000Genomes | |
| tmp_1_26826500_G_T | 441 | C>F | No | 1000Genomes | |
| tmp_1_26826502_G_C | 442 | V>L | No | 1000Genomes | |
| ENSVATH00137002 | 458 | K>Q | No | 1000Genomes | |
| tmp_1_26826696_G_C | 469 | G>A | No | 1000Genomes | |
| tmp_1_26826698_G_C | 470 | D>H | No | 1000Genomes | |
| tmp_1_26826709_A_C | 473 | E>D | No | 1000Genomes | |
| ENSVATH01520381 | 485 | S>T | No | 1000Genomes |
No associated diseases with Q9C994
No regional properties for Q9C994
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9C994 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
| xenobiotic transport | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05497 | YDR338C | Uncharacterized transporter YDR338C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9SYD6 | DTX42 | Protein DETOXIFICATION 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPH1 | DTX22 | Protein DETOXIFICATION 22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HQ05 | DTX8 | Protein DETOXIFICATION 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4Q3 | DTX32 | Protein DETOXIFICATION 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49660 | DTX56 | Protein DETOXIFICATION 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FHB6 | DTX16 | Protein DETOXIFICATION 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ1 | DTX27 | Protein DETOXIFICATION 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNC1 | DTX28 | Protein DETOXIFICATION 28 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPV4 | DTX31 | Protein DETOXIFICATION 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIA5 | DTX1 | Protein DETOXIFICATION 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W488 | DTX21 | Protein DETOXIFICATION 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSAEKGLLV | VSDREEVNKK | DGFLRETKKL | SYIAGPMIAV | NSSMYVLQVI | SIMMVGHLGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFLSSTAIAV | SFCSVTGFSV | VFGLASALET | LCGQANGAKQ | YEKLGVHTYT | GIVSLFLVCI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLSLLWTYIG | DILSLIGQDA | MVAQEAGKFA | TWLIPALFGY | ATLQPLVRFF | QAQSLILPLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MSSVSSLCIH | IVLCWSLVFK | FGLGSLGAAI | AIGVSYWLNV | TVLGLYMTFS | SSCSKSRATI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SMSLFEGMGE | FFRFGIPSAS | MICLEWWSFE | FLVLLSGILP | NPKLEASVLS | VCLSTQSSLY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIPESLGAAA | STRVANELGA | GNPKQARMAV | YTAMVITGVE | SIMVGAIVFG | ARNVFGYLFS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SETEVVDYVK | SMAPLLSLSV | IFDALHAALS | GVARGSGRQD | IGAYVNLAAY | YLFGIPTAIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAFGFKMRGR | GLWIGITVGS | CVQAVLLGLI | VILTNWKKQA | RKARERVMGD | EYEEKESEEE |
| HEYIS |