Q9FNC1

PR
Gene name
DTX28
Protein name
Protein DETOXIFICATION 28
Names
AtDTX28, Multidrug and toxic compound extrusion protein 28, MATE protein 28
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G44050
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FNC1

Entry ID Method Resolution Chain Position Source
AF-Q9FNC1-F1 Predicted AlphaFoldDB

73 variants for Q9FNC1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07326725 5 D>E No 1000Genomes
ENSVATH03344832 6 D>G No 1000Genomes
ENSVATH12483507 6 D>N No 1000Genomes
ENSVATH03344833 7 E>D No 1000Genomes
ENSVATH03344834 8 A>S No 1000Genomes
ENSVATH03344836 9 E>V No 1000Genomes
ENSVATH03344837 10 G>A No 1000Genomes
ENSVATH00704044 11 I>V No 1000Genomes
ENSVATH07326726 12 L>S No 1000Genomes
ENSVATH03344839 25 V>M No 1000Genomes
ENSVATH03344841 26 A>E No 1000Genomes
tmp_5_17722563_A_C 27 E>A No 1000Genomes
ENSVATH03344842 30 N>D No 1000Genomes
tmp_5_17722593_T_C 37 I>T No 1000Genomes
ENSVATH07326730 50 P>Q No 1000Genomes
tmp_5_17722688_G_A 69 A>T No 1000Genomes
ENSVATH12483510 78 A>T No 1000Genomes
ENSVATH07326732 80 I>T No 1000Genomes
tmp_5_17722890_G_A 107 G>D No 1000Genomes
ENSVATH12483542 115 Y>N No 1000Genomes
tmp_5_17722919_A_G 117 M>V No 1000Genomes
tmp_5_17722925_G_C 119 G>R No 1000Genomes
ENSVATH07326737 129 L>V No 1000Genomes
ENSVATH00704050 132 F>C No 1000Genomes
ENSVATH07326738 132 F>L No 1000Genomes
tmp_5_17722987_G_A 139 M>I No 1000Genomes
ENSVATH07326741 162 I>V No 1000Genomes
tmp_5_17723082_A_G 171 H>R No 1000Genomes
ENSVATH07326742 175 A>V No 1000Genomes
ENSVATH12483565 191 S>L No 1000Genomes
tmp_5_17724332_A_T 195 I>F No 1000Genomes
tmp_5_17724333_T_A 195 I>N No 1000Genomes
ENSVATH00704070 200 S>A No 1000Genomes
tmp_5_17724353_G_T 202 V>L No 1000Genomes
ENSVATH14583818 207 V>M No 1000Genomes
ENSVATH12483754 213 Y>F No 1000Genomes
ENSVATH12483815 216 E>D No 1000Genomes
tmp_5_17724416_A_G 223 I>V No 1000Genomes
ENSVATH07326777 234 V>I No 1000Genomes
ENSVATH12483816 235 F>C No 1000Genomes
ENSVATH12483816 235 F>Y No 1000Genomes
ENSVATH00704072 246 C>F No 1000Genomes
tmp_5_17724500_A_G 251 T>A No 1000Genomes
ENSVATH07326779 256 E>K No 1000Genomes
tmp_5_17724709_G_A 288 M>I No 1000Genomes
ENSVATH03344880 289 T>A No 1000Genomes
tmp_5_17724716_A_T 291 N>Y No 1000Genomes
tmp_5_17724917_C_T 317 L>F No 1000Genomes
ENSVATH12483845 320 F>L No 1000Genomes
tmp_5_17725441_G_A 334 G>D No 1000Genomes
tmp_5_17725470_A_G 344 I>V No 1000Genomes
ENSVATH07326803 347 V>L No 1000Genomes
tmp_5_17725491_T_A 351 L>I No 1000Genomes
ENSVATH07326804 351 L>S No 1000Genomes
ENSVATH07326806 361 I>V No 1000Genomes
tmp_5_17725533_C_A 365 L>I No 1000Genomes
ENSVATH12483896 369 G>S No 1000Genomes
ENSVATH07326807 370 W>* No 1000Genomes
tmp_5_17725602_C_A 388 L>I No 1000Genomes
ENSVATH14583843 391 F>L No 1000Genomes
ENSVATH07326811 411 W>* No 1000Genomes
ENSVATH07326812 417 F>I No 1000Genomes
ENSVATH00704088 433 V>I No 1000Genomes
ENSVATH07326814 442 V>I No 1000Genomes
ENSVATH07326817 444 G>S No 1000Genomes
ENSVATH00704090 455 M>L No 1000Genomes
tmp_5_17726011_A_T 464 I>F No 1000Genomes
ENSVATH07326820 465 T>N No 1000Genomes
ENSVATH07326824 474 A>V No 1000Genomes
ENSVATH00704092 476 N>I No 1000Genomes
tmp_5_17726169_T_G 479 V>G No 1000Genomes
ENSVATH14583844 484 W>L No 1000Genomes
ENSVATH12483944 488 D>N No 1000Genomes

No associated diseases with Q9FNC1

No regional properties for Q9FNC1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9FNC1

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
antiporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

1 GO annotations of biological process

Name Definition
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05497 YDR338C Uncharacterized transporter YDR338C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9SYD6 DTX42 Protein DETOXIFICATION 42 Arabidopsis thaliana (Mouse-ear cress) PR
F4HPH1 DTX22 Protein DETOXIFICATION 22 Arabidopsis thaliana (Mouse-ear cress) PR
F4HQ05 DTX8 Protein DETOXIFICATION 8 Arabidopsis thaliana (Mouse-ear cress) PR
F4I4Q3 DTX32 Protein DETOXIFICATION 32 Arabidopsis thaliana (Mouse-ear cress) PR
O49660 DTX56 Protein DETOXIFICATION 56 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C994 DTX14 Protein DETOXIFICATION 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FHB6 DTX16 Protein DETOXIFICATION 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FKQ1 DTX27 Protein DETOXIFICATION 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPV4 DTX31 Protein DETOXIFICATION 31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIA5 DTX1 Protein DETOXIFICATION 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W488 DTX21 Protein DETOXIFICATION 21 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGERDDEAEG ILEKAKIPLL KDQNVAEEEN GEIKKEIWLE TKKLWRIVGP AIFTRVTTNL
70 80 90 100 110 120
IFVITQAFAG HLGELELAAI SIVNNVIIGF NYSLFIGMAT ALETLCGQAF GAKKYDMFGV
130 140 150 160 170 180
YLQRSWIVLF LFSILLLPMY IFATPILKFM GQPDDIAELS GIISVWAIPT HFSFAFFFPI
190 200 210 220 230 240
NRFLQCQLKN SVIAISSGVS LVVHIFVCWL FVYVLELGVI GTIATANVSW WLNVFILFTY
250 260 270 280 290 300
TTCGGCPLTW TGFSMESFTR LWEFTKLSAS SGIMVCLENW YYRMLIVMTG NLEDARIDVD
310 320 330 340 350 360
SMSICMSING LEMMVPLAFF AGTSVRVANE LGAGNGKRAR FAMIISVTQS LIIGIIISVL
370 380 390 400 410 420
IYFLLDQIGW MFSSSETVLK AVNNLSILLS FAILLNSVQP VLSGVAVGSG WQSLVAFINL
430 440 450 460 470 480
GCYYFIGLPL GIVMGWMFKF GVKGIWAGMI FGGTMVQTLI LIFITMRCDW EKEAQNAKVR
490
VNKWSVSDAR K