AiPD: Autoinhibited Protein Database

Gene name	DTX56
Protein name	Protein DETOXIFICATION 56
Names	AtDTX56, Multidrug and toxic compound extrusion protein 56, MATE protein 56, Protein RESISTANT TO HIGH CARBON DIOXIDE 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G22790
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

445-491 (Predicted disordered autoinhibitory region) PR

445-491 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O49660-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_11976600_A_G	10	L>S	No	1000Genomes
tmp_4_11976304_G_A	109	H>Y	No	1000Genomes
ENSVATH00531801	138	T>I	No	1000Genomes
ENSVATH02910843	145	D>E	No	1000Genomes
tmp_4_11976177_T_C	151	K>R	No	1000Genomes
ENSVATH14282587	156	Y>F	No	1000Genomes
ENSVATH02910841	166	F>L	No	1000Genomes
tmp_4_11976105_C_G	175	S>T	No	1000Genomes
ENSVATH00531799	225	L>I	No	1000Genomes
ENSVATH00531798	232	V>A	No	1000Genomes
tmp_4_11975899_C_G	244	G>R	No	1000Genomes
ENSVATH00531797	247	N>D	No	1000Genomes
ENSVATH02910837	249	S>C	No	1000Genomes
tmp_4_11975803_T_A	276	I>F	No	1000Genomes
ENSVATH12156373	287	P>Q	No	1000Genomes
ENSVATH06755292	306	A>S	No	1000Genomes
tmp_4_11975650_T_C	327	N>D	No	1000Genomes
ENSVATH06755291	329	K>T	No	1000Genomes
tmp_4_11975617_T_C	338	T>A	No	1000Genomes
tmp_4_11975610_A_G	340	I>T	No	1000Genomes
ENSVATH02910834	340	I>V	No	1000Genomes
ENSVATH02910832	343	I>V	No	1000Genomes
ENSVATH12156371	351	L>F	No	1000Genomes
ENSVATH00531792	370	L>I	No	1000Genomes
tmp_4_11975482_C_G	383	A>P	No	1000Genomes
ENSVATH00531791	393	M>V	No	1000Genomes
ENSVATH14282586	406	S>Y	No	1000Genomes
ENSVATH12156366	426	T>I	No	1000Genomes
tmp_4_11975347_C_T	428	A>T	No	1000Genomes
tmp_4_11975310_A_G	440	I>T	No	1000Genomes
ENSVATH06755285	448	L>F	No	1000Genomes
ENSVATH12156365	450	L>F	No	1000Genomes
ENSVATH12156304	453	L>S	No	1000Genomes
ENSVATH02910825	478	D>E	No	1000Genomes
tmp_4_11975166_T_C	488	D>G	No	1000Genomes
ENSVATH12156303	490	H>D	No	1000Genomes

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	150 - 171	IPR001611-1
repeat	Leucine-rich repeat	194 - 215	IPR001611-2
repeat	Leucine-rich repeat	216 - 237	IPR001611-3
repeat	Leucine-rich repeat	238 - 259	IPR001611-4
repeat	Leucine-rich repeat	260 - 280	IPR001611-5
repeat	Leucine-rich repeat	281 - 302	IPR001611-6
domain	Guanylate kinase-like domain	414 - 597	IPR008144
domain	Guanylate kinase/L-type calcium channel beta subunit	414 - 600	IPR008145

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
antiporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
xenobiotic transmembrane transporter activity	Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

Name	Definition
cellular response to carbon dioxide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
regulation of stomatal opening	Any process that modulates the frequency, rate or extent of stomatal opening.
xenobiotic detoxification by transmembrane export across the plasma membrane	A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q05497	YDR338C	Uncharacterized transporter YDR338C	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9SYD6	DTX42	Protein DETOXIFICATION 42	Arabidopsis thaliana (Mouse-ear cress)	PR
F4HPH1	DTX22	Protein DETOXIFICATION 22	Arabidopsis thaliana (Mouse-ear cress)	PR
F4HQ05	DTX8	Protein DETOXIFICATION 8	Arabidopsis thaliana (Mouse-ear cress)	PR
F4I4Q3	DTX32	Protein DETOXIFICATION 32	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C994	DTX14	Protein DETOXIFICATION 14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FHB6	DTX16	Protein DETOXIFICATION 16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FKQ1	DTX27	Protein DETOXIFICATION 27	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FNC1	DTX28	Protein DETOXIFICATION 28	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LPV4	DTX31	Protein DETOXIFICATION 31	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIA5	DTX1	Protein DETOXIFICATION 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W488	DTX21	Protein DETOXIFICATION 21	Arabidopsis thaliana (Mouse-ear cress)	PR