Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q94C59

Entry ID Method Resolution Chain Position Source
AF-Q94C59-F1 Predicted AlphaFoldDB

42 variants for Q94C59

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04678199 18 I>V No 1000Genomes
tmp_1_10888344_G_A 21 A>T No 1000Genomes
ENSVATH04678200 21 A>V No 1000Genomes
ENSVATH12408838 25 E>V No 1000Genomes
ENSVATH14013258 30 K>R No 1000Genomes
ENSVATH04678201 42 E>G No 1000Genomes
ENSVATH01131238 87 T>N No 1000Genomes
tmp_1_10888555_C_T 91 T>M No 1000Genomes
ENSVATH01131239 92 K>N No 1000Genomes
ENSVATH01131240 99 M>V No 1000Genomes
tmp_1_10888593_G_A 104 E>K No 1000Genomes
ENSVATH14013259 128 E>K No 1000Genomes
tmp_1_10888674_T_G 131 S>A No 1000Genomes
tmp_1_10888678_A_G 132 E>G No 1000Genomes
ENSVATH14013260 135 V>I No 1000Genomes
tmp_1_10888707_G_A 142 A>T No 1000Genomes
ENSVATH01131243 149 V>I No 1000Genomes
ENSVATH01131244 150 T>A No 1000Genomes
ENSVATH12408839 157 E>D No 1000Genomes
ENSVATH12408840 167 E>D No 1000Genomes
ENSVATH01131246 170 T>S No 1000Genomes
ENSVATH01131247 181 V>F No 1000Genomes
tmp_1_10888883_T_G 200 D>E No 1000Genomes
ENSVATH12408841 205 L>F No 1000Genomes
ENSVATH04678204 207 G>R No 1000Genomes
tmp_1_10888908_C_T 209 P>S No 1000Genomes
tmp_1_10888930_C_G 216 A>G No 1000Genomes
ENSVATH01131248 260 E>D No 1000Genomes
tmp_1_10889074_A_G 264 D>G No 1000Genomes
ENSVATH14013263 266 A>V No 1000Genomes
tmp_1_10889082_A_C 267 T>P No 1000Genomes
tmp_1_10889145_G_A 288 E>K No 1000Genomes
ENSVATH01131250 311 M>I No 1000Genomes
ENSVATH14013264 322 P>S No 1000Genomes
ENSVATH01131252 353 I>M No 1000Genomes
tmp_1_10889483_G_A 372 V>I No 1000Genomes
tmp_1_10889570_G_T 401 A>S No 1000Genomes
ENSVATH04678213 428 D>H No 1000Genomes
tmp_1_10889672_A_G 435 T>A No 1000Genomes
ENSVATH00052534 437 S>C No 1000Genomes
ENSVATH01131260 450 E>Q No 1000Genomes
tmp_1_10889907_A_G 482 E>G No 1000Genomes

No associated diseases with Q94C59

3 regional properties for Q94C59

Type Name Position InterPro Accession
domain CRAL-TRIO lipid binding domain 258 - 428 IPR001251
domain GOLD domain 433 - 534 IPR009038
domain CRAL/TRIO, N-terminal domain 176 - 244 IPR011074

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein
  • Cytoplasm
  • Mainly membrane-associated
  • Also cytoplasmic (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to auxin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
protein localization involved in auxin polar transport Any protein localization that is involved in auxin polar transport.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5SYC1 CLVS2 Clavesin-2 Homo sapiens (Human) PR
Q9BTX7 TTPAL Alpha-tocopherol transfer protein-like Homo sapiens (Human) PR
Q92503 SEC14L1 SEC14-like protein 1 Homo sapiens (Human) PR
Q8IUQ0 CLVS1 Clavesin-1 Homo sapiens (Human) PR
Q9UDX3 SEC14L4 SEC14-like protein 4 Homo sapiens (Human) PR
B5MCN3 SEC14L6 Putative SEC14-like protein 6 Homo sapiens (Human) PR
Q8BG92 Clvs2 Clavesin-2 Mus musculus (Mouse) PR
Q9D4C9 Clvs1 Clavesin-1 Mus musculus (Mouse) PR
Q9D3D0 Ttpal Alpha-tocopherol transfer protein-like Mus musculus (Mouse) PR
Q8R0F9 Sec14l4 SEC14-like protein 4 Mus musculus (Mouse) PR
A6JFQ6 Clvs1 Clavesin-1 Rattus norvegicus (Rat) PR
A6JUQ6 Clvs2 Clavesin-2 Rattus norvegicus (Rat) PR
Q09270 C34C12.6 CRAL-TRIO domain-containing protein C34C12.6 Caenorhabditis elegans PR
Q8GXC6 SFH5 Phosphatidylinositol/phosphatidylcholine transfer protein SFH5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW3 SFH7 Phosphatidylinositol/phosphatidylcholine transfer protein SFH7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SI13 SFH10 Phosphatidylinositol/phosphatidylcholine transfer protein SFH10 Arabidopsis thaliana (Mouse-ear cress) PR
F4IHJ0 SFH8 Phosphatidylinositol/phosphatidylcholine transfer protein SFH8 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZE9 SFH3 Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 Arabidopsis thaliana (Mouse-ear cress) PR
F4J7S8 SFH9 Phosphatidylinositol/phosphatidylcholine transfer protein SFH9 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A34 SFH12 Phosphatidylinositol/phosphatidylcholine transfer protein SFH12 Arabidopsis thaliana (Mouse-ear cress) PR
F4JVA6 SFH6 Phosphatidylinositol/phosphatidylcholine transfer protein SFH6 Arabidopsis thaliana (Mouse-ear cress) PR
Q56WK6 PATL1 Patellin-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56Z59 PATL3 Patellin-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q56ZI2 PATL2 Patellin-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M0R2 PATL5 Patellin-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q5SPP0 clvs2 Clavesin-2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTAEVKVEEK QVESEVVIAP AVVPEETTVK AVVEETKVEE DESKPEGVEK SASFKEESDF
70 80 90 100 110 120
FADLKESEKK ALSDLKSKLE EAIVDNTLLK TKKKESSPMK EKKEEVVKPE AEVEKKKEEA
130 140 150 160 170 180
AEEKVEEEKK SEAVVTEEAP KAETVEAVVT EEIIPKEEVT TVVEKVEEET KEEEKKTEDV
190 200 210 220 230 240
VTEEVKAETI EVEDEDESVD KDIELWGVPL LPSKGAESTD VILLKFLRAR DFKVNEAFEM
250 260 270 280 290 300
LKKTLKWRKQ NKIDSILGEE FGEDLATAAY MNGVDRESHP VCYNVHSEEL YQTIGSEKNR
310 320 330 340 350 360
EKFLRWRFQL MEKGIQKLNL KPGGVTSLLQ IHDLKNAPGV SRTEIWVGIK KVIETLQDNY
370 380 390 400 410 420
PEFVSRNIFI NVPFWFYAMR AVLSPFLTQR TKSKFVVARP AKVRETLLKY IPADELPVQY
430 440 450 460 470 480
GGFKTVDDTE FSNETVSEVV VKPGSSETIE IPAPETEGTL VWDIAVLGWE VNYKEEFVPT
490 500 510 520 530
EEGAYTVIVQ KVKKMGANEG PIRNSFKNSQ AGKIVLTVDN VSGKKKKVLY RYRTKTESSS