Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q56Z59

Entry ID Method Resolution Chain Position Source
AF-Q56Z59-F1 Predicted AlphaFoldDB

28 variants for Q56Z59

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05130282 21 L>I No 1000Genomes
ENSVATH00138731 24 S>P No 1000Genomes
ENSVATH01524362 28 E>A No 1000Genomes
ENSVATH01524362 28 E>V No 1000Genomes
ENSVATH00138730 38 T>A No 1000Genomes
ENSVATH13796009 48 N>D No 1000Genomes
tmp_1_27155446_G_A 55 T>I No 1000Genomes
tmp_1_27155398_G_T 71 T>K No 1000Genomes
ENSVATH00138729 117 S>C No 1000Genomes
ENSVATH01524361 125 K>N No 1000Genomes
ENSVATH05130281 142 Q>H No 1000Genomes
tmp_1_27155179_G_A 144 T>I No 1000Genomes
ENSVATH01524360 163 S>N No 1000Genomes
ENSVATH00138727 175 E>D No 1000Genomes
tmp_1_27155035_C_T 192 R>K No 1000Genomes
ENSVATH05130278 206 V>M No 1000Genomes
tmp_1_27154946_C_A 222 G>C No 1000Genomes
ENSVATH14471770 237 E>K No 1000Genomes
ENSVATH13796006 248 K>N No 1000Genomes
ENSVATH05130277 255 T>I No 1000Genomes
ENSVATH05130276 269 F>L No 1000Genomes
tmp_1_27154542_T_C 320 N>D No 1000Genomes
tmp_1_27154437_T_C 355 T>A No 1000Genomes
ENSVATH13795999 411 E>D No 1000Genomes
ENSVATH01524356 411 E>V No 1000Genomes
tmp_1_27153966_G_T 444 P>T No 1000Genomes
tmp_1_27153951_G_A 449 P>S No 1000Genomes
tmp_1_27153827_A_T 490 L>H No 1000Genomes

No associated diseases with Q56Z59

3 regional properties for Q56Z59

Type Name Position InterPro Accession
domain CRAL-TRIO lipid binding domain 202 - 377 IPR001251
domain GOLD domain 353 - 487 IPR009038
domain CRAL/TRIO, N-terminal domain 125 - 188 IPR011074

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein
  • Cytoplasm
  • Mainly membrane-associated
  • Also cytoplasmic (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5SYC1 CLVS2 Clavesin-2 Homo sapiens (Human) PR
Q9BTX7 TTPAL Alpha-tocopherol transfer protein-like Homo sapiens (Human) PR
Q92503 SEC14L1 SEC14-like protein 1 Homo sapiens (Human) PR
Q8IUQ0 CLVS1 Clavesin-1 Homo sapiens (Human) PR
Q9UDX3 SEC14L4 SEC14-like protein 4 Homo sapiens (Human) PR
B5MCN3 SEC14L6 Putative SEC14-like protein 6 Homo sapiens (Human) PR
Q8BG92 Clvs2 Clavesin-2 Mus musculus (Mouse) PR
Q9D4C9 Clvs1 Clavesin-1 Mus musculus (Mouse) PR
Q9D3D0 Ttpal Alpha-tocopherol transfer protein-like Mus musculus (Mouse) PR
Q8R0F9 Sec14l4 SEC14-like protein 4 Mus musculus (Mouse) PR
A6JFQ6 Clvs1 Clavesin-1 Rattus norvegicus (Rat) PR
A6JUQ6 Clvs2 Clavesin-2 Rattus norvegicus (Rat) PR
Q09270 C34C12.6 CRAL-TRIO domain-containing protein C34C12.6 Caenorhabditis elegans PR
Q8GXC6 SFH5 Phosphatidylinositol/phosphatidylcholine transfer protein SFH5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW3 SFH7 Phosphatidylinositol/phosphatidylcholine transfer protein SFH7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SI13 SFH10 Phosphatidylinositol/phosphatidylcholine transfer protein SFH10 Arabidopsis thaliana (Mouse-ear cress) PR
F4IHJ0 SFH8 Phosphatidylinositol/phosphatidylcholine transfer protein SFH8 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZE9 SFH3 Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 Arabidopsis thaliana (Mouse-ear cress) PR
F4J7S8 SFH9 Phosphatidylinositol/phosphatidylcholine transfer protein SFH9 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A34 SFH12 Phosphatidylinositol/phosphatidylcholine transfer protein SFH12 Arabidopsis thaliana (Mouse-ear cress) PR
F4JVA6 SFH6 Phosphatidylinositol/phosphatidylcholine transfer protein SFH6 Arabidopsis thaliana (Mouse-ear cress) PR
Q56WK6 PATL1 Patellin-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56ZI2 PATL2 Patellin-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C59 PATL4 Patellin-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M0R2 PATL5 Patellin-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q5SPP0 clvs2 Clavesin-2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAEEPTTTTL VTPEKLPSPS LTPSEVSEST QDALPTETET LEKVTETNPP ETADTTTKPE
70 80 90 100 110 120
EETAAEHHPP TVTETETAST EKQEVKDEAS QKEVAEEKKS MIPQNLGSFK EESSKLSDLS
130 140 150 160 170 180
NSEKKSLDEL KHLVREALDN HQFTNTPEEV KIWGIPLLED DRSDVVLLKF LRAREFKVKD
190 200 210 220 230 240
SFAMLKNTIK WRKEFKIDEL VEEDLVDDLD KVVFMHGHDR EGHPVCYNVY GEFQNKELYN
250 260 270 280 290 300
KTFSDEEKRK HFLRTRIQFL ERSIRKLDFS SGGVSTIFQV NDMKNSPGLG KKELRSATKQ
310 320 330 340 350 360
AVELLQDNYP EFVFKQAFIN VPWWYLVFYT VIGPFMTPRS KSKLVFAGPS RSAETLFKYI
370 380 390 400 410 420
SPEQVPVQYG GLSVDPCDCN PDFSLEDSAS EITVKPGTKQ TVEIIIYEKC ELVWEIRVTG
430 440 450 460 470 480
WEVSYKAEFV PEEKDAYTVV IQKPRKMRPS DEPVLTHSFK VNELGKVLLT VDNPTSKKKK
LVYRFNVKPL