Q8GXC6

PR
Gene name
SFH5 (At1g75370, F1B16.10)
Protein name
Phosphatidylinositol/phosphatidylcholine transfer protein SFH5
Names
Protein SEC FOURTEEN HOMOLOGS 5, AtSFH5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G75370
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q8GXC6

Entry ID Method Resolution Chain Position Source
7Y10 X-ray 210 A A/B 75-365 PDB
7Y11 X-ray 195 A A/B 75-365 PDB
AF-Q8GXC6-F1 Predicted AlphaFoldDB

24 variants for Q8GXC6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05148630 13 F>C No 1000Genomes
ENSVATH05148629 24 E>D No 1000Genomes
ENSVATH13811931 38 T>I No 1000Genomes
ENSVATH01538331 40 I>M No 1000Genomes
tmp_1_28279424_T_C 68 R>G No 1000Genomes
tmp_1_28279373_C_T 85 V>I No 1000Genomes
ENSVATH00143709 86 E>Q No 1000Genomes
tmp_1_28279317_C_A 103 L>F No 1000Genomes
tmp_1_28278867_C_T 197 E>K No 1000Genomes
ENSVATH05148615 213 I>R No 1000Genomes
tmp_1_28278810_G_A 216 P>S No 1000Genomes
tmp_1_28278463_C_T 268 R>H No 1000Genomes
ENSVATH05148607 306 N>S No 1000Genomes
tmp_1_28277839_C_G 373 D>H No 1000Genomes
ENSVATH13811912 404 R>K No 1000Genomes
ENSVATH13811909
ENSVATH00143703
 421 T>S No 1000Genomes
tmp_1_28277328_G_T 461 P>T No 1000Genomes
ENSVATH05148601 475 W>R No 1000Genomes
tmp_1_28277109_T_C 534 N>D No 1000Genomes
tmp_1_28277079_C_T 544 E>K No 1000Genomes
ENSVATH14480896 560 L>W No 1000Genomes
tmp_1_28276808_C_A 598 R>L No 1000Genomes
tmp_1_28276790_T_C 604 Y>C No 1000Genomes
ENSVATH05148595 607 K>R No 1000Genomes

No associated diseases with Q8GXC6

2 regional properties for Q8GXC6

Type Name Position InterPro Accession
domain CRAL-TRIO lipid binding domain 155 - 329 IPR001251
domain CRAL/TRIO, N-terminal domain 110 - 135 IPR011074

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UDX3 SEC14L4 SEC14-like protein 4 Homo sapiens (Human) PR
Q5SYC1 CLVS2 Clavesin-2 Homo sapiens (Human) PR
Q9BTX7 TTPAL Alpha-tocopherol transfer protein-like Homo sapiens (Human) PR
Q92503 SEC14L1 SEC14-like protein 1 Homo sapiens (Human) PR
B5MCN3 SEC14L6 Putative SEC14-like protein 6 Homo sapiens (Human) PR
Q8IUQ0 CLVS1 Clavesin-1 Homo sapiens (Human) PR
Q8R0F9 Sec14l4 SEC14-like protein 4 Mus musculus (Mouse) PR
Q8BG92 Clvs2 Clavesin-2 Mus musculus (Mouse) PR
Q9D4C9 Clvs1 Clavesin-1 Mus musculus (Mouse) PR
Q9D3D0 Ttpal Alpha-tocopherol transfer protein-like Mus musculus (Mouse) PR
A6JFQ6 Clvs1 Clavesin-1 Rattus norvegicus (Rat) PR
A6JUQ6 Clvs2 Clavesin-2 Rattus norvegicus (Rat) PR
Q09270 C34C12.6 CRAL-TRIO domain-containing protein C34C12.6 Caenorhabditis elegans PR
Q56ZI2 PATL2 Patellin-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C59 PATL4 Patellin-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q56WK6 PATL1 Patellin-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56Z59 PATL3 Patellin-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M0R2 PATL5 Patellin-5 Arabidopsis thaliana (Mouse-ear cress) PR
F4IHJ0 SFH8 Phosphatidylinositol/phosphatidylcholine transfer protein SFH8 Arabidopsis thaliana (Mouse-ear cress) PR
F4J7S8 SFH9 Phosphatidylinositol/phosphatidylcholine transfer protein SFH9 Arabidopsis thaliana (Mouse-ear cress) PR
F4JVA6 SFH6 Phosphatidylinositol/phosphatidylcholine transfer protein SFH6 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A34 SFH12 Phosphatidylinositol/phosphatidylcholine transfer protein SFH12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SI13 SFH10 Phosphatidylinositol/phosphatidylcholine transfer protein SFH10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW3 SFH7 Phosphatidylinositol/phosphatidylcholine transfer protein SFH7 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZE9 SFH3 Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 Arabidopsis thaliana (Mouse-ear cress) PR
Q501H5 SFH13 Phosphatidylinositol/phosphatidylcholine transfer protein SFH13 Arabidopsis thaliana (Mouse-ear cress) PR
Q5SPP0 clvs2 Clavesin-2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSGSLDRFAR PCFEGVSSND ERRERRSDFE VSEDEKKTRI GNFNFKKKAA KASSKLRHSL
70 80 90 100 110 120
KKKGSSRRRS SDRTFSLTIE DIHDVEELRA VDEFRNLLVS ENLLPPTLDD YHIMLRFLKA
130 140 150 160 170 180
RKFDIGKTKL MWSNMIKWRK DFGTDTIFED FEFEEFDEVL KYYPHGYHGV DKEGRPVYIE
190 200 210 220 230 240
RLGLVDPAKL MQVTTVERFI RYHVREFEKT VNIKLPACCI AAKRHIDSST TILDVQGVGF
250 260 270 280 290 300
KNFSKPARDL IIQLQKIDND NYPETLHRMF IINGGSGFKL VWATVKQFLD PKTVTKIHVI
310 320 330 340 350 360
GNKYQNKLLE IIDASQLPDF LGGTCTCADR GGCMRSDKGP WNDPEILKML QSGGPLCRHN
370 380 390 400 410 420
SALNSFSRVS SCDKPSFSGI KASDTSTAES GSEVEEMASP KVNRELRVPK LTPVCEDIRG
430 440 450 460 470 480
TAISYPTDSS EYDSPMVDKV VDVAWMAHEK PKASKGSEDT PDSGKIRTVT YIWRWLMMFF
490 500 510 520 530 540
VNLFTLLISL ALPQREGHSQ SESSVDGPNA RESRPPSPAF ATIAERNVFS SVVNRLGDLE
550 560 570 580 590 600
KQVETLHSKR HEMPREKEEL LNTAVYRVDA LEAELIATKK ALHEALMRQD DLLAYIDREE
610
DEKYHKKKKV CW